CMAUP Plant Collective Molecular Activities

Plant Name: Nauclea officinalis

Taxonomic Information:

Plant ID: NPO28864
Plant Latin Name: Nauclea officinalis
Taxonomy Genus: Nauclea
Taxonomy Family: Rubiaceae

Plant External Links:

NCBI TaxonomyDB: 1009495
Plant-of-the-World-Online: 77078143-1

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

Philippines; Indonesia; Cambodia; Vietnam; China; Laos; Thailand

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	FFAR1; FFAR4;
Peptide receptor (family A GPCR)	NPSR1;
Enzyme_unclassified	ALPL; ALOX12; HSD17B2; HSD17B10; ALOX15; NOX4; APEX1; POLB;
Hydrolase	ACHE;
Miscellaneous ion channel	BCL2;
Protein Kinase	KDR; MET; AXL; FLT3; CDK1; PIM1; CDK6; IGF1R; PRKCA; AURKB;
Lyase	CA2; CA12; CA1; CA14; CA7;
Nuclear hormone receptor subfamily 1 group C	PPARA;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Oxidoreductase	TYR;
Lysine demethylase	KDM4E;
Serine protease	F10;
Transcription Factor	AHR; NFKB1;
Transferase	FUT7;
SLC superfamily of solute carriers	SLCO1B1;
Unclassified	LMNA; FABP3; FABP5; FABP4;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Enzyme_unclassified	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P05186	CHEMBL5979
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	HSD17B2	Estradiol 17-beta-dehydrogenase 2	P37059	CHEMBL2789
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	APEX1	DNA-(apurinic or apyrimidinic site) lyase	P27695	CHEMBL5619
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
Miscellaneous ion channel	BCL2	Apoptosis regulator Bcl-2	P10415	CHEMBL4860
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Oxidoreductase	TYR	Tyrosinase	P14679	CHEMBL1973
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Protein Kinase	MET	Hepatocyte growth factor receptor	P08581	CHEMBL3717
Protein Kinase	AXL	Tyrosine-protein kinase receptor UFO	P30530	CHEMBL4895
Protein Kinase	FLT3	Tyrosine-protein kinase receptor FLT3	P36888	CHEMBL1974
Protein Kinase	CDK1	Cyclin-dependent kinase 1	P06493	CHEMBL308
Protein Kinase	PIM1	Serine/threonine-protein kinase PIM1	P11309	CHEMBL2147
Protein Kinase	CDK6	Cyclin-dependent kinase 6	Q00534	CHEMBL2508
Protein Kinase	IGF1R	Insulin-like growth factor I receptor	P08069	CHEMBL1957
Protein Kinase	PRKCA	Protein kinase C alpha	P17252	CHEMBL299
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Serine protease	F10	Coagulation factor X	P00742	CHEMBL244
SLC superfamily of solute carriers	SLCO1B1	Solute carrier organic anion transporter family member 1B1	Q9Y6L6	CHEMBL1697668
Small molecule receptor (family A GPCR)	FFAR1	Free fatty acid receptor 1	O14842	CHEMBL4422
Small molecule receptor (family A GPCR)	FFAR4	G-protein coupled receptor 120	Q5NUL3	CHEMBL5339
Transcription Factor	AHR	Aryl hydrocarbon receptor	P35869	CHEMBL3201
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Transferase	FUT7	Alpha-(1,3)-fucosyltransferase 7	Q11130	CHEMBL3596077
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.432E-10	5.196E-07	CA1, CA12, CA14, CA2, CA7
BP	GO:0009987; cellular process	GO:0043066; negative regulation of apoptotic process	3.409E-08	2.855E-05	ALOX12, AURKB, AXL, BCL2, CDK1, FFAR4, IGF1R, KDR, LMNA, NFKB1, NR1H4, PIM1, PRKCA
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	4.931E-08	3.472E-05	CA1, CA12, CA14, CA2, CA7
BP	GO:0065007; biological regulation	GO:0010817; regulation of hormone levels	1.640E-07	8.929E-05	ACHE, CYP1A1, CYP1B1, FFAR1, FFAR4, HSD17B2, NFKB1, NR1H4, PRKCA, SLCO1B1
MF	GO:0005488; binding	GO:0005504; fatty acid binding	3.955E-07	1.758E-04	FABP3, FABP4, FABP5, FFAR4
BP	GO:0065007; biological regulation	GO:0048878; chemical homeostasis	8.855E-07	3.268E-04	ALOX12, BCL2, CA12, CA2, CA7, FABP3, FABP4, FFAR1, MET, NOX4, NPSR1, NR1H4
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.308E-06	4.130E-04	CA1, CA12, CA2, CA7
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	1.309E-06	4.130E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0050896; response to stimulus	GO:0009725; response to hormone	1.758E-06	5.172E-04	ALPL, APEX1, BCL2, CA2, CYP1A2, FABP3, FFAR4, FLT3, NFKB1, PPARA
BP	GO:0050896; response to stimulus	GO:0009611; response to wounding	3.069E-06	8.535E-04	ACHE, ALOX15, BCL2, CDK1, CYP1A1, PPARA
MF	GO:0005488; binding	GO:0019825; oxygen binding	3.259E-06	8.654E-04	CYP1A1, CYP1A2, CYP1B1, NOX4
BP	GO:0008152; metabolic process	GO:0055114; oxidation-reduction process	3.858E-06	9.883E-04	ALOX12, ALOX15, APEX1, CYP1A1, CYP1A2, CYP1B1, HSD17B10, HSD17B2, KDM4E, NOX4, TYR
BP	GO:0009987; cellular process	GO:0006286; base-excision repair, base-free sugar-phosphate removal	5.071E-06	1.175E-03	APEX1, POLB
BP	GO:0008152; metabolic process	GO:2001303; lipoxin A4 biosynthetic process	5.071E-06	1.175E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0047977; hepoxilin-epoxide hydrolase activity	5.071E-06	1.175E-03	ALOX12, ALOX15
BP	GO:0040011; locomotion	GO:0030335; positive regulation of cell migration	6.070E-06	1.391E-03	ALOX12, BCL2, F10, IGF1R, KDR, MET, NOX4, PRKCA
MF	GO:0003824; catalytic activity	GO:0035173; histone kinase activity	7.333E-06	1.613E-03	AURKB, CDK1, PRKCA
BP	GO:0008152; metabolic process	GO:0070988; demethylation	9.727E-06	2.037E-03	APEX1, CYP1A1, CYP1A2, KDM4E
BP	GO:0009987; cellular process	GO:0070301; cellular response to hydrogen peroxide	1.112E-05	2.262E-03	APEX1, AXL, CDK1, CYP1B1
BP	GO:0009987; cellular process	GO:0071407; cellular response to organic cyclic compound	1.324E-05	2.598E-03	ALPL, APEX1, CYP1A1, CYP1B1, FLT3, NFKB1, NOX4
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	1.425E-05	2.746E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	1.519E-05	2.803E-03	CA2, CA7
BP	GO:0019740; nitrogen utilization	GO:0006808; regulation of nitrogen utilization	1.519E-05	2.803E-03	BCL2, NR1H4
MF	GO:0003824; catalytic activity	GO:0004052; arachidonate 12-lipoxygenase activity	1.519E-05	2.803E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0051120; hepoxilin A3 synthase activity	1.519E-05	2.803E-03	ALOX12, ALOX15
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	1.892E-05	3.349E-03	CYP1A1, CYP1A2, CYP1B1
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	1.892E-05	3.349E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	2.449E-05	4.232E-03	FABP3, FABP4, FABP5
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	3.034E-05	5.082E-03	CYP1A1, CYP1A2
MF	GO:0005488; binding	GO:0005506; iron ion binding	3.064E-05	5.093E-03	ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0016572; histone phosphorylation	3.472E-05	5.727E-03	AURKB, CDK1, PRKCA
BP	GO:0050896; response to stimulus	GO:0032496; response to lipopolysaccharide	3.680E-05	6.025E-03	ALPL, AXL, CYP1A1, CYP1A2, NFKB1, NR1H4
MF	GO:0005488; binding	GO:0008134; transcription factor binding	4.850E-05	7.233E-03	AHR, APEX1, BCL2, FLT3, NFKB1, NR1H4, PIM1, PPARA
BP	GO:0008152; metabolic process	GO:0051122; hepoxilin biosynthetic process	5.049E-05	7.330E-03	ALOX12, ALOX15
BP	GO:0008152; metabolic process	GO:0018108; peptidyl-tyrosine phosphorylation	6.283E-05	8.770E-03	AXL, FLT3, IGF1R, KDR, MET

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	2.473E-10	3.758E-08	CA12, CA1, CA2, CA7, CA14
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	4.358E-06	2.208E-04	HSD17B2, CYP1A1, CYP1B1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	3.551E-06	2.208E-04	CDK6, PIM1, BCL2, CYP1B1, PRKCA, MET, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	8.776E-06	2.668E-04	CDK6, KDR, BCL2, PRKCA, MET, NFKB1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	2.343E-05	5.087E-04	CDK6, FLT3, BCL2, PRKCA, MET, NFKB1, IGF1R
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	7.926E-06	2.668E-04	CYP1A2, HSD17B2, CYP1A1, CYP1B1
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	7.121E-05	1.199E-03	PIM1, BCL2, PRKCA, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	1.587E-05	4.020E-04	FABP3, FABP4, FABP5, PPARA
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04510	Focal adhesion	7.887E-05	1.199E-03	KDR, BCL2, PRKCA, MET, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	7.687E-05	1.199E-03	BCL2, PRKCA, NFKB1, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04014	Ras signaling pathway	1.365E-04	1.729E-03	KDR, PRKCA, MET, NFKB1, IGF1R
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	9.273E-05	1.281E-03	CYP1A2, CYP1A1, CYP1B1
09160 Human Diseases	09167 Infectious diseases	hsa05161	Hepatitis B	2.948E-04	3.201E-03	CDK6, BCL2, PRKCA, NFKB1
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	2.675E-04	3.128E-03	FLT3, PIM1, NFKB1
09160 Human Diseases	09161 Cancers	hsa05214	Glioma	3.945E-04	3.998E-03	CDK6, PRKCA, IGF1R
09160 Human Diseases	09161 Cancers	hsa05218	Melanoma	5.115E-04	4.573E-03	CDK6, MET, IGF1R
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	1.018E-03	6.686E-03	KDR, PRKCA, MET, IGF1R
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	6.503E-04	5.203E-03	FLT3, MET, NFKB1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05203	Viral carcinogenesis	1.056E-03	6.686E-03	POLB, CDK6, CDK1, NFKB1
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	5.115E-04	4.573E-03	SLCO1B1, CA2, NR1H4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5.549E-04	4.686E-03	CYP1A2, CYP1A1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	9.887E-04	6.686E-03	BCL2, NFKB1, IGF1R
Unclassified	Unclassified	hsa01100	Metabolic pathways	1.290E-03	7.539E-03	FUT7, HSD17B2, CYP1A2, ALOX15, CYP1A1, ALPL, ALOX12, TYR, HSD17B10
09130 Environmental Information Processing	09132 Signal transduction	hsa04015	Rap1 signaling pathway	1.175E-03	7.142E-03	KDR, PRKCA, MET, IGF1R
09160 Human Diseases	09161 Cancers	hsa05222	Small cell lung cancer	8.951E-04	6.479E-03	CDK6, BCL2, NFKB1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	7.793E-04	5.923E-03	CYP1A2, CYP1A1, CYP1B1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	KDR;
I00-I99: Diseases of the circulatory system	Heart disease	I00-I52	MET;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	TYR;
I00-I99: Diseases of the circulatory system	Deep vein thrombosis	I80-I82, I80.2	F10;
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR;
C00-D49: Neoplasms	Breast cancer	C50	CDK1; IGF1R; KDR; FLT3; BCL2;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	F10;
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	MET;
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR;
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities	Genetic disease	Q00-Q99	ALPL;
C00-D49: Neoplasms	Cancer	C00-C96	PIM1; MET; CDK1; IGF1R; KDR; NFKB1; FLT3; ACHE; CA1; BCL2;
L00-L99: Diseases of the skin and subcutaneous tissue	Melasma	L81.1	TYR;
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	MET;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR;
C00-D49: Neoplasms	Glioblastoma	NA	FLT3;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE; CA1;
NA: NA	GIST	NA	FLT3;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	KDR;
C00-D49: Neoplasms	Malignant adrenal gland cancer	C74.0	IGF1R;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
C00-D49: Neoplasms	AML	NA	KDR; FLT3;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	ACHE; CA2;
C00-D49: Neoplasms	Ocular cancer	C69	APEX1;
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	IGF1R;
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	MET;
I00-I99: Diseases of the circulatory system	Acute coronary syndrome	I74	F10;
C00-D49: Neoplasms	Lymphoma	C81-C86	BCL2;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR;
C00-D49: Neoplasms	Metastasis	C00-C97	AXL;
E00-E89: Endocrine, nutritional and metabolic diseases	Atrial fibrillation	E78, I48	F10;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Attention deficit hyperactivity disorder	F90	F10;
NA: NA	Christmas disease	NA	F10;
K00-K95: Diseases of the digestive system	Chemotherapy-induced mucositis	K12.3	MET;
C00-D49: Neoplasms	Liver cancer	C22	IGF1R; KDR;
C00-D49: Neoplasms	Leukemia	C90-C95	FLT3; BCL2;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	MET; IGF1R; KDR;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	AURKB;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Hemophilia	D66-D68	F10;
C00-D49: Neoplasms	Ovarian cancer	C56	KDR;
C00-D49: Neoplasms	Chronic lymphocytic leukaemia	C91	BCL2;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2; CA1;
NA: NA	HIV infections	NA	AHR;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE; CA1;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE;
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR; FLT3;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	CDK1; IGF1R; ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriatic disorder	L40	IGF1R;
C00-D49: Neoplasms	Gastric cancer	C16	KDR;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE;
C00-D49: Neoplasms	Myeloid leukemia	C92	FLT3;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR;
C00-D49: Neoplasms	Myelofibrosis	C94.4, D47.4	FLT3;
I00-I99: Diseases of the circulatory system	Deep venous clots	I80.2	F10;
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	FLT3; BCL2;
I00-I99: Diseases of the circulatory system	Prophylaxis of deep vein thrombosis	I80-I82, I80.2	F10;
C00-D49: Neoplasms	Prostate cancer	C61	FLT3; BCL2;
C00-D49: Neoplasms	Renal cancer	C64	KDR; F10;
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	NPSR1;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	IGF1R; KDR; FLT3;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
C00-D49: Neoplasms	Melanoma	C43	KDR; TYR;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Hematology	D50-D77	F10;
NA: NA	Hematopoietic stem cell transplantation	NA	FLT3;
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	FFAR1;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MET; IGF1R; KDR; AXL;
I00-I99: Diseases of the circulatory system	Coagulation	I80-I82	F10;
C00-D49: Neoplasms	CLL	NA	FLT3;
NA: NA	Anaplastic mixed oligoastrocytoma	NA	FLT3;
C00-D49: Neoplasms	Solid tumours	C00-D48	MET; AURKB; IGF1R; KDR; FLT3;
G00-G99: Diseases of the nervous system G00-G99	Motor neurone disease	G12.2	IGF1R;
C00-D49: Neoplasms	Multiple myeloma	C90	IGF1R; AHR; BCL2;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE;
C00-D49: Neoplasms	Gliosarcoma	NA	FLT3;
C00-D49: Neoplasms	Glioma	C71	KDR;
C00-D49: Neoplasms	Colon cancer	C50	FLT3; ALPL;
I00-I99: Diseases of the circulatory system	Thrombosis	I80-I82	F10;
I00-I99: Diseases of the circulatory system	Thromboembolic disorders	I80-I82	F10;
I00-I99: Diseases of the circulatory system	Thromboembolism	I80-I82	F10;
C00-D49: Neoplasms	Thyroid cancer	C73	KDR;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE;
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR;
C00-D49: Neoplasms	Advanced melanoma	C43	BCL2;
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR;
L00-L99: Diseases of the skin and subcutaneous tissue	Vitiligo	L80	TYR;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
I00-I99: Diseases of the circulatory system	Venous thromboembolism	I80-I82	F10;
I00-I99: Diseases of the circulatory system	Venous thrombosis	I80-I82	F10;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Growth failure	R62.8	IGF1R;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1; FFAR1;
NA: NA	Edema	NA	CA2;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR;
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR;
I00-I99: Diseases of the circulatory system	Angina pectoris	I20	F10;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE;
A00-B99: Certain infectious and parasitic diseases	Anthelmintic	B89	ALPL;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE;
NA: NA	Upper abdominal bloating	NA	ACHE;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
J00-J99: Diseases of the respiratory system	Airway inflammation	J00-J99	FLT3;
G00-G99: Diseases of the nervous system G00-G99	Amyotrophic lateral sclerosis	G12.2	BCL2;
NA: NA	Haemophilia B	NA	F10;
H00-H59: Diseases of the eye and adnexa	Graves' ophthalmopathy	H06.2	IGF1R;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	FFAR1;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKB; FLT3;
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR;
I00-I99: Diseases of the circulatory system	Bleeding	I74, I80-I82	F10;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Blood coagulation disorders	D65-D68	F10;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
C00-D49: Neoplasms	Metastatic HER2-negative gastric cancer	NA	MET;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases