Plant Name: Xylocarpus granatum
Taxonomic Information:
Plant ID: NPO28813
Plant Latin Name: Xylocarpus granatum
Taxonomy Genus: Xylocarpus
Taxonomy Family: Meliaceae
Plant External Links:
NCBI TaxonomyDB:
241841
Plant-of-the-World-Online:
n.a.
Used in Medicines:
Country/Region:
Philippines; India; Rwanda; Thailand; Kenya; TanzaniaTraditional Medicine System:
Indian Folk; SiddhaGeographical Distribution:
Philippines; India; Rwanda; Thailand; Kenya; Tanzania
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| OXER1; | |
| RXRA; | |
| SMN1;SMN2; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Methyl-lysine/arginine binding protein | SMN1;SMN2 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
| Nuclear hormone receptor subfamily 2 group B | RXRA | Retinoid X receptor alpha | P19793 | CHEMBL2061 |
| Small molecule receptor (family A GPCR) | OXER1 | Oxoeicosanoid receptor 1 | Q8TDS5 | CHEMBL1628461 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0005488; binding | GO:0050692; DBD domain binding | 4.659E-04 | 9.222E-01 | RXRA |
| BP | GO:0051179; localization | GO:0015721; bile acid and bile salt transport | 4.652E-03 | 1.000E+00 | RXRA |
| BP | GO:0022414; reproductive process | GO:0060135; maternal process involved in female pregnancy | 5.736E-03 | 1.000E+00 | RXRA |
| BP | GO:0009987; cellular process | GO:0051289; protein homotetramerization | 1.145E-02 | 1.000E+00 | RXRA |
| BP | GO:0008152; metabolic process | GO:0030817; regulation of cAMP biosynthetic process | 1.514E-02 | 1.000E+00 | OXER1 |
| CC | GO:0032991; macromolecular complex | GO:0090575; RNA polymerase II transcription factor complex | 2.021E-02 | 1.000E+00 | RXRA |
| CC | GO:0032991; macromolecular complex | GO:0043235; receptor complex | 4.918E-02 | 1.000E+00 | RXRA |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09160 Human Diseases | 09161 Cancers | hsa05216 | Thyroid cancer | 4.344E-03 | 2.547E-02 | RXRA |
| 09160 Human Diseases | 09161 Cancers | hsa05223 | Non-small cell lung cancer | 8.377E-03 | 2.547E-02 | RXRA |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04920 | Adipocytokine signaling pathway | 1.046E-02 | 2.547E-02 | RXRA |
| 09150 Organismal Systems | 09152 Endocrine system | hsa03320 | PPAR signaling pathway | 1.031E-02 | 2.547E-02 | RXRA |
| 09160 Human Diseases | 09161 Cancers | hsa05222 | Small cell lung cancer | 1.285E-02 | 2.569E-02 | RXRA |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 1.061E-02 | 2.547E-02 | RXRA |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04919 | Thyroid hormone signaling pathway | 1.760E-02 | 2.973E-02 | RXRA |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04932 | Non-alcoholic fatty liver disease (NAFLD) | 2.248E-02 | 2.997E-02 | RXRA |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05160 | Hepatitis C | 1.982E-02 | 2.973E-02 | RXRA |
| 09160 Human Diseases | 09161 Cancers | hsa05202 | Transcriptional misregulation in cancer | 2.676E-02 | 3.211E-02 | RXRA |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Cutaneous T-cell lymphoma | C84.0, C84.1 | RXRA; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
