Plant Name: Corydalis remota
Taxonomic Information:
Plant ID: NPO28698
Plant Latin Name: Corydalis remota
Taxonomy Genus: Corydalis
Taxonomy Family: Papaveraceae
Plant External Links:
NCBI TaxonomyDB:
1577778
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: | CYP2D6; |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 2 | CYP2D6 | Cytochrome P450 2D6 | P10635 | CHEMBL289 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Unclassified | F3 | Coagulation factor III | P13726 | CHEMBL4081 |
| Unclassified | SIGMAR1 | Sigma opioid receptor | Q99720 | CHEMBL287 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0001676; long-chain fatty acid metabolic process | 2.055E-02 | 1.000E+00 | CYP2D6 |
| BP | GO:0009987; cellular process | GO:2001237; negative regulation of extrinsic apoptotic signaling pathway | 2.116E-02 | 1.000E+00 | LMNA |
| BP | GO:0009987; cellular process | GO:0071456; cellular response to hypoxia | 2.136E-02 | 1.000E+00 | LMNA |
| CC | GO:0044425; membrane part | GO:0031226; intrinsic component of plasma membrane | 3.135E-02 | 1.000E+00 | F3, SIGMAR1 |
| CC | GO:0043226; organelle | GO:0014069; postsynaptic density | 4.038E-02 | 1.000E+00 | SIGMAR1 |
| MF | GO:0060089; molecular transducer activity | GO:0004985; opioid receptor activity | 1.656E-03 | 1.000E+00 | SIGMAR1 |
| MF | GO:0003824; catalytic activity | GO:0008395; steroid hydroxylase activity | 7.023E-03 | 1.000E+00 | CYP2D6 |
| MF | GO:0005488; binding | GO:0019825; oxygen binding | 9.287E-03 | 1.000E+00 | CYP2D6 |
| MF | GO:0005488; binding | GO:0020037; heme binding | 2.625E-02 | 1.000E+00 | CYP2D6 |
| MF | Unclassified; | GO:0004872; receptor activity | 3.482E-02 | 1.000E+00 | F3, SIGMAR1 |
| MF | Unclassified; | GO:0004871; signal transducer activity | 4.187E-02 | 1.000E+00 | F3, SIGMAR1 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| J00-J99: Diseases of the respiratory system | Adult respiratory distress syndrome | J80 | F3; |
| I00-I99: Diseases of the circulatory system | Bleeding | I74, I80-I82 | F3; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Insomnia | F51.0, G47.0 | CYP2D6; |
| C00-D49: Neoplasms | Pancreatic cancer | C25 | F3; |
| A00-B99: Certain infectious and parasitic diseases | Malaria | B54 | CYP2D6; |
| G00-G99: Diseases of the nervous system G00-G99 | Migraine | G43 | CYP2D6; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
