CMAUP Plant Collective Molecular Activities

Plant Name: Aster tataricus

Taxonomic Information:

Plant ID: NPO28688
Plant Latin Name: Aster tataricus
Taxonomy Genus: Aster
Taxonomy Family: Asteraceae

Plant External Links:

NCBI TaxonomyDB: 588669
Plant-of-the-World-Online: 182425-1

Used in Medicines:

Country/Region:

South Korea; China

Traditional Medicine System:

TCM

Medicinal Functions:

Antibacterial; Antifungal; Antitussive; Cancer; Expectorant

Geographical Distribution:

South Africa; Mongolia; United States; Germany; Japan; China; South Korea; Russia

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR; NPSR1;
Small molecule receptor (family A GPCR)	FFAR1; FFAR4;
Protein Kinase	MET; AXL; FLT3; CDK1; PIM1; KDR; IGF1R; AURKB;
Lyase	CA12; CA7; CA4;
Nuclear hormone receptor subfamily 1 group C	PPARA;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Oxidoreductase	TYR; XDH;
Enzyme_unclassified	ALOX12; CBR1; AKR1B1; HSD17B2; HSD17B10; NOX4; AKR1B10; ALOX15; POLB;
Transcription Factor	AHR; TP53;
Unclassified	LMNA; FABP5; FABP4; FABP3; APP;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP19A1; CYP2C19; CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	CBR1	Carbonyl reductase [NADPH] 1	P16152	CHEMBL5586
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	HSD17B2	Estradiol 17-beta-dehydrogenase 2	P37059	CHEMBL2789
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Oxidoreductase	TYR	Tyrosinase	P14679	CHEMBL1973
Oxidoreductase	XDH	Xanthine dehydrogenase	P47989	CHEMBL1929
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Protein Kinase	MET	Hepatocyte growth factor receptor	P08581	CHEMBL3717
Protein Kinase	AXL	Tyrosine-protein kinase receptor UFO	P30530	CHEMBL4895
Protein Kinase	FLT3	Tyrosine-protein kinase receptor FLT3	P36888	CHEMBL1974
Protein Kinase	CDK1	Cyclin-dependent kinase 1	P06493	CHEMBL308
Protein Kinase	PIM1	Serine/threonine-protein kinase PIM1	P11309	CHEMBL2147
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Protein Kinase	IGF1R	Insulin-like growth factor I receptor	P08069	CHEMBL1957
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Small molecule receptor (family A GPCR)	FFAR1	Free fatty acid receptor 1	O14842	CHEMBL4422
Small molecule receptor (family A GPCR)	FFAR4	G-protein coupled receptor 120	Q5NUL3	CHEMBL5339
Transcription Factor	AHR	Aryl hydrocarbon receptor	P35869	CHEMBL3201
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	APP	Beta amyloid A4 protein	P05067	CHEMBL2487
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0019825; oxygen binding	4.089E-10	6.849E-07	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, NOX4
MF	GO:0005488; binding	GO:0005506; iron ion binding	1.141E-09	1.381E-06	ALOX12, ALOX15, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, XDH
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	3.280E-09	2.747E-06	CYP1A1, CYP1A2, CYP1B1, CYP2C19
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	9.197E-08	4.005E-05	CYP1A1, CYP1A2, CYP1B1, CYP2C19
BP	GO:0009987; cellular process	GO:0043066; negative regulation of apoptotic process	9.544E-08	4.075E-05	AKR1B1, ALOX12, AURKB, AXL, CDK1, FFAR4, IGF1R, KDR, LMNA, NR1H4, PIM1, TP53
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	1.357E-07	5.470E-05	CYP19A1, CYP1A1, CYP1A2, CYP1B1
MF	GO:0005488; binding	GO:0020037; heme binding	2.402E-07	8.716E-05	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, NOX4
MF	GO:0005488; binding	GO:0005504; fatty acid binding	2.673E-07	9.238E-05	FABP3, FABP4, FABP5, FFAR4
MF	GO:0003824; catalytic activity	GO:0009055; electron transfer activity	2.803E-06	6.935E-04	AKR1B1, CYP19A1, CYP1A2, NOX4, XDH
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	3.679E-06	8.614E-04	CA12, CA4, CA7
BP	GO:0008152; metabolic process	GO:2001303; lipoxin A4 biosynthetic process	4.181E-06	9.291E-04	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0047977; hepoxilin-epoxide hydrolase activity	4.181E-06	9.291E-04	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0016616; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4.517E-06	9.934E-04	AKR1B1, AKR1B10, CBR1, HSD17B10, HSD17B2
BP	GO:0009987; cellular process	GO:0070301; cellular response to hydrogen peroxide	7.554E-06	1.582E-03	AKR1B1, AXL, CDK1, CYP1B1
BP	GO:0050896; response to stimulus	GO:0055093; response to hyperoxia	1.066E-05	2.037E-03	CYP1A1, POLB, TP53
MF	GO:0003824; catalytic activity	GO:0004052; arachidonate 12-lipoxygenase activity	1.253E-05	2.292E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0051120; hepoxilin A3 synthase activity	1.253E-05	2.292E-03	ALOX12, ALOX15
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	1.416E-05	2.506E-03	CYP1A1, CYP1A2, CYP1B1
MF	GO:0060089; molecular transducer activity	GO:0038023; signaling receptor activity	1.405E-05	2.506E-03	AHR, AXL, FFAR1, FFAR4, FLT3, IGF1R, KDR, MET, NPSR1, NR1H4, PPARA, TSHR
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	1.833E-05	3.001E-03	FABP3, FABP4, FABP5
BP	GO:0008152; metabolic process	GO:0022900; electron transport chain	2.025E-05	3.241E-03	AKR1B1, CYP19A1, CYP1A2, NOX4, XDH
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	2.502E-05	3.892E-03	CYP1A1, CYP1A2
BP	GO:0040011; locomotion	GO:0030335; positive regulation of cell migration	3.039E-05	4.502E-03	ALOX12, APP, IGF1R, KDR, MET, NOX4, TP53
BP	GO:0008152; metabolic process	GO:0018108; peptidyl-tyrosine phosphorylation	3.927E-05	5.482E-03	AXL, FLT3, IGF1R, KDR, MET
BP	GO:0008152; metabolic process	GO:0051122; hepoxilin biosynthetic process	4.165E-05	5.740E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	4.708E-05	6.268E-03	CYP19A1, CYP1A1, CYP2C19
MF	Unclassified;	GO:0004872; receptor activity	4.721E-05	6.268E-03	AHR, AXL, FFAR1, FFAR4, FLT3, IGF1R, KDR, MET, NPSR1, NR1H4, PPARA, TSHR
BP	GO:0008152; metabolic process	GO:0046777; protein autophosphorylation	5.040E-05	6.494E-03	AURKB, FLT3, IGF1R, KDR, PIM1
BP	GO:0009987; cellular process	GO:0070374; positive regulation of ERK1 and ERK2 cascade	5.164E-05	6.575E-03	ALOX15, APP, FFAR4, KDR, NOX4
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	5.602E-05	7.051E-03	CA12, CA4, CA7
MF	GO:0005488; binding	GO:0001221; transcription cofactor binding	6.087E-05	7.531E-03	AHR, PPARA, TP53
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	6.239E-05	7.632E-03	CYP1A2, CYP2C19
BP	GO:0050896; response to stimulus	GO:1901653; cellular response to peptide	6.682E-05	8.128E-03	AKR1B1, APP, IGF1R, TP53, TSHR
BP	GO:0065007; biological regulation	GO:0055081; anion homeostasis	8.304E-05	9.827E-03	CA12, FABP3, NR1H4

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	4.898E-08	5.045E-06	HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R
Unclassified	Unclassified	hsa01100	Metabolic pathways	4.636E-07	1.550E-05	CBR1, ALOX15, AKR1B1, ALOX12, CYP2C19, TYR, CYP19A1, HSD17B10, AKR1B10, HSD17B2, CYP1A2, CYP1A1, XDH
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.047E-07	5.392E-06	CYP1A2, HSD17B2, CYP1A1, CYP1B1, CYP19A1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	6.020E-07	1.550E-05	CBR1, CYP1A2, CYP1A1, CYP1B1, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	7.036E-06	1.208E-04	CBR1, ALOX15, ALOX12, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.351E-05	1.740E-04	CBR1, CYP1A2, CYP1A1, CYP1B1
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	1.080E-05	1.588E-04	FABP3, FABP4, FABP5, PPARA
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	7.290E-05	6.257E-04	APP, ALOX15, ALOX12, CYP2C19
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	6.956E-05	6.257E-04	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	4.943E-06	1.018E-04	CA12, CA4, CA7
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	2.612E-05	2.989E-04	CYP1A2, ALOX15, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05218	Melanoma	3.855E-04	2.836E-03	TP53, MET, IGF1R
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	3.249E-04	2.574E-03	FLT3, TP53, MET
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	7.074E-04	4.554E-03	KDR, TP53, MET, IGF1R
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	4.502E-04	3.092E-03	FLT3, TP53, MET, IGF1R
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	1.638E-03	9.921E-03	AKR1B10, AKR1B1
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	3.885E-05	4.002E-04	CYP1A2, XDH

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR; FLT3;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	CDK1; IGF1R;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	AKR1B1; TYR;
H00-H59: Diseases of the eye and adnexa	Macular degeneration	H35.3	APP;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
C00-D49: Neoplasms	Solid tumours	C00-D48	MET; AURKB; IGF1R; KDR; FLT3; TP53;
H00-H59: Diseases of the eye and adnexa	Graves' ophthalmopathy	H06.2	IGF1R;
C00-D49: Neoplasms	Glioblastoma	NA	FLT3;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Growth failure	R62.8	IGF1R;
C00-D49: Neoplasms	Metastatic HER2-negative gastric cancer	NA	MET;
C00-D49: Neoplasms	Gastric cancer	C16	KDR;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	IGF1R; KDR; FLT3; TP53;
C00-D49: Neoplasms	Colon cancer	C50	FLT3;
L00-L99: Diseases of the skin and subcutaneous tissue	Vitiligo	L80	TYR;
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	FLT3;
C00-D49: Neoplasms	Prostate cancer	C61	FLT3;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperuricemia	E79.0	XDH;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	FFAR1;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53;
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53;
C00-D49: Neoplasms	Renal cancer	C64	KDR;
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR;
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1;
G00-G99: Diseases of the nervous system G00-G99	Encephalopathy	G93.4	XDH;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	KDR;
C00-D49: Neoplasms	Breast cancer	C50	CDK1; IGF1R; KDR; FLT3; CYP19A1;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
I00-I99: Diseases of the circulatory system	Cerebral amyloid angiopathy	I68.0	APP;
C00-D49: Neoplasms	Multiple myeloma	C90	IGF1R; AHR;
K00-K95: Diseases of the digestive system	Chemotherapy-induced mucositis	K12.3	MET;
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR;
C00-D49: Neoplasms	Metastasis	C00-C97	AXL;
NA: NA	Hematopoietic stem cell transplantation	NA	FLT3;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	AURKB; TP53;
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	IGF1R;
C00-D49: Neoplasms	AML	NA	KDR; FLT3;
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53;
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	MET;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	MET; IGF1R; KDR;
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1;
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR;
C00-D49: Neoplasms	Liver cancer	C22	IGF1R; KDR;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53;
C00-D49: Neoplasms	Leukemia	C90-C95	FLT3;
I00-I99: Diseases of the circulatory system	Heart failure	I50	XDH;
I00-I99: Diseases of the circulatory system	Heart disease	I00-I52	MET;
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR; AKR1B1; TP53;
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR;
S00-T88: Injury, poisoning and certain other consequences of external causes	Brain injury	S09.90	APP;
J00-J99: Diseases of the respiratory system	Asthma	J45	CBR1;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR;
E00-E89: Endocrine, nutritional and metabolic diseases	Amyloidosis	E85	APP;
C00-D49: Neoplasms	Cancer	C00-C96	PIM1; MET; CDK1; IGF1R; KDR; FLT3; TP53; APP;
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	AKR1B1; XDH;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	AKR1B1;
NA: NA	Geographic retinal atrophy	NA	APP;
C00-D49: Neoplasms	Gliosarcoma	NA	FLT3;
G00-G99: Diseases of the nervous system G00-G99	Diagnostic imaging	G30, I73.9	APP;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic complication	E08-E13	AKR1B1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic cataract	E10.36, E11.36	AKR1B1;
C00-D49: Neoplasms	Myeloid leukemia	C92	FLT3;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR;
C00-D49: Neoplasms	Myelofibrosis	C94.4, D47.4	FLT3;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	APP;
G00-G99: Diseases of the nervous system G00-G99	Mild to moderate alzheimer disease	G30	APP;
NA: NA	Anaplastic mixed oligoastrocytoma	NA	FLT3;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;
J00-J99: Diseases of the respiratory system	Airway inflammation	J00-J99	FLT3;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	APP;
NA: NA	HIV infections	NA	AHR;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	NPSR1; APP;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
C00-D49: Neoplasms	Melanoma	C43	KDR; TYR;
L00-L99: Diseases of the skin and subcutaneous tissue	Melasma	L81.1	TYR;
C00-D49: Neoplasms	Thyroid cancer	C73	KDR; TSHR;
H00-H59: Diseases of the eye and adnexa	Age related macular degeneration	H35.3	APP;
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	MET;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	KDR;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MET; IGF1R; KDR; AXL;
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	FFAR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	AKR1B1; FFAR1;
C00-D49: Neoplasms	Malignant adrenal gland cancer	C74.0	IGF1R;
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR;
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;
C00-D49: Neoplasms	CLL	NA	FLT3;
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	MET;
NA: NA	GIST	NA	FLT3;
C00-D49: Neoplasms	Glioma	C71	KDR; APP;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKB; FLT3; TP53;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	AKR1B1;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriatic disorder	L40	IGF1R;
C00-D49: Neoplasms	Ovarian cancer	C56	KDR;
G00-G99: Diseases of the nervous system G00-G99	Motor neurone disease	G12.2	IGF1R;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperuricaemia in gout	E79.0, M10	XDH;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases