Plant Name: Pyrus calleryana
Taxonomic Information:
Plant ID: NPO28586
Plant Latin Name: Pyrus calleryana
Taxonomy Genus: Pyrus
Taxonomy Family: Rosaceae
Plant External Links:
NCBI TaxonomyDB:
36597
Plant-of-the-World-Online:
730740-1
Used in Medicines:
Unknown.
Geographical Distribution:
Georgia; United States; Vietnam; China; Japan; Taiwan; Iraq
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Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| MAOA; | |
| AKR1B1; | |
| KDM4E; | |
| RAB9A; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | AKR1B1 | Aldose reductase | P15121 | CHEMBL1900 |
| Lysine demethylase | KDM4E | Lysine-specific demethylase 4D-like | B2RXH2 | CHEMBL1293226 |
| Oxidoreductase | MAOA | Monoamine oxidase A | P21397 | CHEMBL1951 |
| Unclassified | RAB9A | Ras-related protein Rab-9A | P51151 | CHEMBL1293294 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0006584; catecholamine metabolic process | 2.896E-05 | 3.153E-01 | AKR1B1, MAOA |
| BP | GO:0008152; metabolic process | GO:0055114; oxidation-reduction process | 3.867E-04 | 6.441E-01 | AKR1B1, KDM4E, MAOA |
| CC | GO:0044464; cell part | GO:0032838; plasma membrane bounded cell projection cytoplasm | 1.380E-02 | 1.000E+00 | AKR1B1 |
| CC | GO:0043226; organelle | GO:0042470; melanosome | 2.075E-02 | 1.000E+00 | RAB9A |
| MF | GO:0003824; catalytic activity | GO:0008131; primary amine oxidase activity | 1.242E-03 | 1.000E+00 | MAOA |
| MF | GO:0003824; catalytic activity | GO:0051213; dioxygenase activity | 1.851E-02 | 1.000E+00 | KDM4E |
| MF | GO:0003824; catalytic activity | GO:0009055; electron transfer activity | 2.218E-02 | 1.000E+00 | AKR1B1 |
| MF | GO:0003824; catalytic activity | GO:0016616; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | 2.442E-02 | 1.000E+00 | AKR1B1 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09105 Amino acid metabolism | hsa00340 | Histidine metabolism | 4.792E-03 | 1.793E-02 | MAOA |
| 09100 Metabolism | 09105 Amino acid metabolism | hsa00360 | Phenylalanine metabolism | 3.396E-03 | 1.793E-02 | MAOA |
| 09100 Metabolism | 09105 Amino acid metabolism | hsa00350 | Tyrosine metabolism | 6.982E-03 | 1.793E-02 | MAOA |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00040 | Pentose and glucuronate interconversions | 7.181E-03 | 1.793E-02 | AKR1B1 |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00052 | Galactose metabolism | 5.987E-03 | 1.793E-02 | AKR1B1 |
| 09100 Metabolism | 09105 Amino acid metabolism | hsa00380 | Tryptophan metabolism | 7.977E-03 | 1.793E-02 | MAOA |
| 09100 Metabolism | 09105 Amino acid metabolism | hsa00260 | Glycine, serine and threonine metabolism | 7.977E-03 | 1.793E-02 | MAOA |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00051 | Fructose and mannose metabolism | 6.385E-03 | 1.793E-02 | AKR1B1 |
| 09160 Human Diseases | 09164 Substance dependence | hsa05030 | Cocaine addiction | 9.765E-03 | 1.793E-02 | MAOA |
| 09100 Metabolism | 09105 Amino acid metabolism | hsa00330 | Arginine and proline metabolism | 9.963E-03 | 1.793E-02 | MAOA |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
