Plant Name: Sarcomelicope glauca
Taxonomic Information:
Plant ID: NPO28560
Plant Latin Name: Sarcomelicope glauca
Taxonomy Genus: Sarcomelicope
Taxonomy Family: Rutaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TSHR; | |
| METAP2; | |
| LMNA; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
| Metallo protease | METAP2 | Methionine aminopeptidase 2 | P50579 | CHEMBL3922 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 8.038E-07 | 1.750E-02 | CYP1A2, CYP2C19 |
| BP | GO:0008152; metabolic process | GO:0097267; omega-hydroxylase P450 pathway | 2.410E-06 | 2.565E-02 | CYP1A2, CYP2C19 |
| BP | GO:0050896; response to stimulus | GO:0042738; exogenous drug catabolic process | 3.534E-06 | 2.565E-02 | CYP1A2, CYP2C19 |
| BP | GO:0008152; metabolic process | GO:0019373; epoxygenase P450 pathway | 1.124E-05 | 6.116E-02 | CYP1A2, CYP2C19 |
| MF | GO:0005488; binding | GO:0019825; oxygen binding | 5.283E-05 | 2.301E-01 | CYP1A2, CYP2C19 |
| MF | GO:0003824; catalytic activity | GO:0004497; monooxygenase activity | 2.371E-04 | 4.365E-01 | CYP1A2, CYP2C19 |
| MF | GO:0005488; binding | GO:0020037; heme binding | 4.301E-04 | 4.901E-01 | CYP1A2, CYP2C19 |
| MF | GO:0060089; molecular transducer activity | GO:0004996; thyroid-stimulating hormone receptor activity | 5.177E-04 | 4.901E-01 | TSHR |
| MF | GO:0003824; catalytic activity | GO:0016705; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | 6.297E-04 | 5.485E-01 | CYP1A2, CYP2C19 |
| MF | GO:0005488; binding | GO:0005506; iron ion binding | 6.708E-04 | 5.618E-01 | CYP1A2, CYP2C19 |
| MF | GO:0003824; catalytic activity | GO:0034875; caffeine oxidase activity | 1.035E-03 | 7.043E-01 | CYP1A2 |
| CC | GO:0016020; membrane | GO:0005789; endoplasmic reticulum membrane | 2.063E-02 | 1.000E+00 | CYP1A2, CYP2C19 |
| CC | GO:0016020; membrane | GO:0031090; organelle membrane | 2.225E-02 | 1.000E+00 | CYP1A2, CYP2C19, LMNA |
| CC | GO:0044464; cell part | GO:0005635; nuclear envelope | 4.149E-02 | 1.000E+00 | LMNA |
| CC | GO:0016020; membrane | GO:0016323; basolateral plasma membrane | 4.723E-02 | 1.000E+00 | TSHR |
| MF | GO:0003824; catalytic activity | GO:0032451; demethylase activity | 1.006E-02 | 1.000E+00 | CYP1A2 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 2.025E-05 | 4.049E-04 | CYP1A2, CYP2C19 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 1.165E-04 | 1.098E-03 | CYP1A2, CYP2C19 |
| 09160 Human Diseases | 09161 Cancers | hsa05204 | Chemical carcinogenesis | 1.647E-04 | 1.098E-03 | CYP1A2, CYP2C19 |
| 09100 Metabolism | 09105 Amino acid metabolism | hsa00380 | Tryptophan metabolism | 9.961E-03 | 2.825E-02 | CYP1A2 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04923 | Regulation of lipolysis in adipocytes | 1.392E-02 | 2.825E-02 | TSHR |
| 09160 Human Diseases | 09162 Immune diseases | hsa05320 | Autoimmune thyroid disease | 1.318E-02 | 2.825E-02 | TSHR |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00140 | Steroid hormone biosynthesis | 1.442E-02 | 2.825E-02 | CYP1A2 |
| 09100 Metabolism | 09108 Metabolism of cofactors and vitamins | hsa00830 | Retinol metabolism | 1.615E-02 | 2.825E-02 | CYP1A2 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04918 | Thyroid hormone synthesis | 1.763E-02 | 2.825E-02 | TSHR |
| 09100 Metabolism | 09110 Biosynthesis of other secondary metabolites | hsa00232 | Caffeine metabolism | 1.250E-03 | 6.248E-03 | CYP1A2 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| E00-E89: Endocrine, nutritional and metabolic diseases | Autoimmune diabetes | E08-E13 | METAP2; |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | METAP2; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Obesity | E66 | METAP2; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
