CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Metallo protease	METAP2;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP2C19;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Metallo protease	METAP2	Methionine aminopeptidase 2	P50579	CHEMBL3922
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Showing 1 to 5 of 5 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	8.038E-07	1.750E-02	CYP1A2, CYP2C19
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	2.410E-06	2.565E-02	CYP1A2, CYP2C19
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	3.534E-06	2.565E-02	CYP1A2, CYP2C19
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	1.124E-05	6.116E-02	CYP1A2, CYP2C19
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	2.063E-02	1.000E+00	CYP1A2, CYP2C19
CC	GO:0016020; membrane	GO:0031090; organelle membrane	2.225E-02	1.000E+00	CYP1A2, CYP2C19, LMNA
CC	GO:0044464; cell part	GO:0005635; nuclear envelope	4.149E-02	1.000E+00	LMNA
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	4.723E-02	1.000E+00	TSHR
MF	GO:0005488; binding	GO:0019825; oxygen binding	5.283E-05	2.301E-01	CYP1A2, CYP2C19
MF	GO:0003824; catalytic activity	GO:0004497; monooxygenase activity	2.371E-04	4.365E-01	CYP1A2, CYP2C19

Showing 1 to 10 of 16 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	2.025E-05	4.049E-04	CYP1A2, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.165E-04	1.098E-03	CYP1A2, CYP2C19
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	9.961E-03	2.825E-02	CYP1A2
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.442E-02	2.825E-02	CYP1A2
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.615E-02	2.825E-02	CYP1A2
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	1.250E-03	6.248E-03	CYP1A2
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1.392E-02	2.825E-02	TSHR
09150 Organismal Systems	09152 Endocrine system	hsa04918	Thyroid hormone synthesis	1.763E-02	2.825E-02	TSHR
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.647E-04	1.098E-03	CYP1A2, CYP2C19
09160 Human Diseases	09162 Immune diseases	hsa05320	Autoimmune thyroid disease	1.318E-02	2.825E-02	TSHR

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Solid tumours	C00-D48	METAP2;
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	METAP2;
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	METAP2;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Sarcomelicope glauca

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities