CMAUP Plant Collective Molecular Activities

Plant Name: Torreya nucifera

Taxonomic Information:

Plant ID: NPO28466
Plant Latin Name: Torreya nucifera
Taxonomy Genus: Torreya
Taxonomy Family: Taxaceae

Plant External Links:

NCBI TaxonomyDB: 50189
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

South Korea

Traditional Medicine System:

Medicinal Functions:

Anodyne; Anthelmintic; Carminative; Digestive; Laxative; Pectoral

Geographical Distribution:

South Korea

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	DRD3; HTR2C;
Peptide receptor (family A GPCR)	OPRD1;
Protein Phosphatase	PTPN1;
Protein Kinase	MAP2K1;
Aspartic protease	BACE1;
Endoplasmic reticular retrotranslocon family	VCP;
Unclassified	MCL1; LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C19;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Aspartic protease	BACE1	Beta-secretase 1	P56817	CHEMBL4822
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Endoplasmic reticular retrotranslocon family	VCP	Transitional endoplasmic reticulum ATPase	P55072	CHEMBL1075145
Peptide receptor (family A GPCR)	OPRD1	Delta opioid receptor	P41143	CHEMBL236
Protein Kinase	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	CHEMBL3587
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335
Small molecule receptor (family A GPCR)	DRD3	Dopamine D3 receptor	P35462	CHEMBL234
Small molecule receptor (family A GPCR)	HTR2C	Serotonin 2c (5-HT2c) receptor	P28335	CHEMBL225
Unclassified	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	CHEMBL4361
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0033554; cellular response to stress	3.886E-05	2.616E-01	LMNA, MAP2K1, MCL1, OPRD1, PTPN1, VCP
BP	GO:0008152; metabolic process	GO:0042327; positive regulation of phosphorylation	7.177E-05	2.616E-01	HTR2C, MAP2K1, OPRD1, PTPN1, VCP
BP	GO:0007610; behavior	GO:0007626; locomotory behavior	8.952E-05	2.616E-01	DRD3, HTR2C, OPRD1
CC	GO:0016020; membrane	GO:0016020; membrane	1.114E-04	2.616E-01	BACE1, CYP2C19, DRD3, HTR2C, LMNA, MAP2K1, MCL1, OPRD1, PTPN1, VCP
BP	GO:0009987; cellular process	GO:2001234; negative regulation of apoptotic signaling pathway	1.457E-04	2.807E-01	LMNA, MCL1, PTPN1
MF	GO:0005488; binding	GO:0071886; 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding	1.035E-03	3.131E-01	HTR2C
MF	GO:0060089; molecular transducer activity	GO:0030594; neurotransmitter receptor activity	1.379E-03	3.661E-01	DRD3, HTR2C
CC	GO:0044464; cell part	GO:0005770; late endosome	2.103E-03	4.180E-01	BACE1, MAP2K1
CC	GO:0044464; cell part	GO:0097443; sorting endosome	3.103E-03	4.537E-01	PTPN1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	1.994E-05	1.574E-03	MAP2K1, HTR2C, CYP2C19
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	3.886E-05	1.574E-03	MAP2K1, LMNA, MCL1
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	2.935E-04	7.923E-03	OPRD1, HTR2C, DRD3
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04540	Gap junction	8.418E-04	1.705E-02	MAP2K1, HTR2C
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	1.557E-03	2.522E-02	OPRD1, MAP2K1
09130 Environmental Information Processing	09132 Signal transduction	hsa04022	cGMP-PKG signaling pathway	2.985E-03	3.454E-02	OPRD1, MAP2K1
09150 Organismal Systems	09152 Endocrine system	hsa04910	Insulin signaling pathway	2.081E-03	2.809E-02	PTPN1, MAP2K1
09150 Organismal Systems	09151 Immune system	hsa04664	Fc epsilon RI signaling pathway	3.349E-02	8.275E-02	MAP2K1
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	3.301E-02	8.275E-02	MAP2K1
09160 Human Diseases	09161 Cancers	hsa05218	Melanoma	3.495E-02	8.275E-02	MAP2K1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Cough	R05	OPRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	OPRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Premature ejaculation	F52.4	OPRD1;
NA: NA	Acute nonspecific diarrhea	NA	OPRD1;
C00-D49: Neoplasms	Overactive bladder disorder	C67, N32.81	OPRD1;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Moderate-to-severe pain	R52, G89	OPRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	OPRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	OPRD1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	OPRD1;
G00-G99: Diseases of the nervous system G00-G99	Acute migraine	G43	OPRD1;
N00-N99: Diseases of the genitourinary system	Bladder disease	N30-N32	OPRD1;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	OPRD1;
NA: NA	Chronic diarrhea associated with inflammatory bowel disease	NA	OPRD1;
K00-K95: Diseases of the digestive system	Diarrhea-predominant IBS	K58.0	OPRD1;
I00-I99: Diseases of the circulatory system	Ischemic heart diseases	I20-I25	OPRD1;
N00-N99: Diseases of the genitourinary system	Urinary incontinence	N39.3, N39.4, R32	OPRD1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases