CMAUP Plant Collective Molecular Activities

Plant Name: Piper sarmentosum

Taxonomic Information:

Plant ID: NPO2846
Plant Latin Name: Piper sarmentosum
Taxonomy Genus: Piper
Taxonomy Family: Piperaceae

Plant External Links:

NCBI TaxonomyDB: 405319
Plant-of-the-World-Online: 683277-1

Used in Medicines:

Country/Region:

Thailand; China; India

Traditional Medicine System:

Indian Folk; TCM

Geographical Distribution:

Madagascar; Philippines; India; Cambodia; Mauritius; Trinidad and Tobago; Vietnam; China; Laos; Thailand

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	CNR2; HCAR2;
Peptide receptor (family A GPCR)	TSHR;
Oxidoreductase	HMGCR;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP1A1; CYP1A2; CYP3A4; CYP19A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Oxidoreductase	HMGCR	HMG-CoA reductase	P04035	CHEMBL402
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Small molecule receptor (family A GPCR)	CNR2	Cannabinoid CB2 receptor	P34972	CHEMBL253
Small molecule receptor (family A GPCR)	HCAR2	Hydroxycarboxylic acid receptor 2	Q8TDS4	CHEMBL3785

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	1.887E-13	4.015E-09	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4
MF	GO:0005488; binding	GO:0019825; oxygen binding	6.826E-12	4.955E-08	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4
MF	GO:0005488; binding	GO:0020037; heme binding	1.457E-09	4.533E-06	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4
MF	GO:0005488; binding	GO:0005506; iron ion binding	4.493E-09	9.784E-06	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	8.380E-09	1.659E-05	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	9.264E-08	1.441E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	1.233E-07	1.579E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0006706; steroid catabolic process	1.809E-07	1.969E-04	CYP19A1, CYP1A2, CYP3A4
MF	GO:0003824; catalytic activity	GO:0070576; vitamin D 24-hydroxylase activity	5.788E-07	5.252E-04	CYP1A1, CYP3A4
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	8.582E-07	7.188E-04	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	1.157E-06	8.400E-04	CYP1A1, CYP1A2
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	1.157E-06	8.400E-04	CYP1A2, CYP3A4
MF	GO:0003824; catalytic activity	GO:0101020; estrogen 16-alpha-hydroxylase activity	1.928E-06	1.272E-03	CYP1A1, CYP3A4
BP	GO:0008152; metabolic process	GO:0002933; lipid hydroxylation	2.892E-06	1.749E-03	CYP1A1, CYP3A4
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	2.892E-06	1.749E-03	CYP1A2, CYP3A4
BP	GO:0008152; metabolic process	GO:0009820; alkaloid metabolic process	4.048E-06	2.382E-03	CYP1A2, CYP3A4
BP	GO:0008152; metabolic process	GO:0050665; hydrogen peroxide biosynthetic process	5.396E-06	2.937E-03	CYP1A1, CYP1A2
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	1.271E-05	5.534E-03	CYP1A2, CYP3A4
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	1.271E-05	5.534E-03	CYP1A2, CYP3A4
BP	GO:0008152; metabolic process	GO:0042359; vitamin D metabolic process	1.271E-05	5.534E-03	CYP1A1, CYP3A4
BP	GO:0009987; cellular process	GO:0071280; cellular response to copper ion	1.501E-05	6.410E-03	CYP1A1, CYP1A2
BP	GO:0050896; response to stimulus	GO:0009636; response to toxic substance	2.144E-05	8.977E-03	CNR2, CYP1A1, CYP1B1, HMGCR
BP	GO:0008152; metabolic process	GO:0006694; steroid biosynthetic process	2.212E-05	9.089E-03	CYP19A1, CYP3A4, HMGCR
BP	GO:0008152; metabolic process	GO:0016125; sterol metabolic process	2.319E-05	9.351E-03	CYP19A1, CYP1B1, HMGCR
CC	GO:0016020; membrane	GO:0031090; organelle membrane	4.210E-03	4.928E-01	CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR
CC	GO:0044464; cell part	GO:0031234; extrinsic component of cytoplasmic side of plasma membrane	3.306E-02	1.000E+00	CNR2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2.147E-11	4.294E-10	CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2.030E-08	2.030E-07	CYP1A2, CYP1A1, CYP1B1, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	3.255E-08	2.170E-07	CYP1A2, CYP1A1, CYP1B1, CYP3A4
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	6.174E-07	3.087E-06	CYP1A2, CYP1A1, CYP1B1
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	1.222E-06	4.888E-06	CYP1A1, CYP1B1, CYP19A1
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2.714E-06	9.047E-06	CYP1A2, CYP1A1, CYP3A4
Unclassified	Unclassified	hsa01100	Metabolic pathways	9.242E-05	2.311E-04	CYP1A2, CYP1A1, HMGCR, CYP3A4, CYP19A1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	7.262E-05	2.075E-04	CYP1A2, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4.157E-04	8.803E-04	CYP1A2, CYP3A4
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	4.402E-04	8.803E-04	HMGCR, CYP3A4
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	3.387E-03	5.645E-03	HCAR2, TSHR
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	6.453E-03	9.927E-03	CNR2, TSHR
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	2.248E-03	4.088E-03	CYP1A2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	CNR2;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Immune disorder	D80-D89	CNR2;
L00-L99: Diseases of the skin and subcutaneous tissue	Atopic dermatitis	L00-L99	CNR2;
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	CNR2;
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1;
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1;
C00-D49: Neoplasms	Breast cancer	C50	CYP19A1;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	CNR2;
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	CNR2;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoporosis	M80-M81, Z79.890	CNR2;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	CNR2;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases