CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	FFAR1; FFAR4;
Enzyme_unclassified	ALPL; TDP1; TERT; ALOX15; PGD; POLB;
Hydrolase	ACHE;
Miscellaneous ion channel	BCL2;
Protein Kinase	MAPK1;
Nuclear hormone receptor subfamily 1 group C	PPARA;
Transcription Factor	NFKB1;
DNA methyltransferase	DNMT1;
ATP-binding cassette	ABCB1;
Unclassified	FABP3; LMNA; FABP5;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
ATP-binding cassette	ABCB1	P-glycoprotein 1	P08183	CHEMBL4302
DNA methyltransferase	DNMT1	DNA (cytosine-5)-methyltransferase 1	P26358	CHEMBL1993
Enzyme_unclassified	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P05186	CHEMBL5979
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	TERT	Telomerase reverse transcriptase	O14746	CHEMBL2916
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	PGD	6-phosphogluconate dehydrogenase	P52209	CHEMBL3404
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Miscellaneous ion channel	BCL2	Apoptosis regulator Bcl-2	P10415	CHEMBL4860

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0005504; fatty acid binding	1.960E-06	6.096E-03	FABP3, FABP5, FFAR4

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	1.023E-04	2.012E-03	BCL2, MAPK1, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	1.609E-04	2.012E-03	BCL2, MAPK1, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	7.092E-04	6.332E-03	MAPK1, PPARA, NFKB1
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	6.521E-06	4.076E-04	LMNA, BCL2, MAPK1, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	3.090E-05	1.288E-03	FABP3, FABP5, PPARA
09150 Organismal Systems	09156 Nervous system	hsa04725	Cholinergic synapse	1.278E-04	2.012E-03	ACHE, BCL2, MAPK1
09150 Organismal Systems	09156 Nervous system	hsa04722	Neurotrophin signaling pathway	1.609E-04	2.012E-03	BCL2, MAPK1, NFKB1
09150 Organismal Systems	09151 Immune system	hsa04621	NOD-like receptor signaling pathway	1.186E-03	8.719E-03	MAPK1, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	1.884E-03	9.307E-03	MAPK1, NFKB1
09150 Organismal Systems	09151 Immune system	hsa04662	B cell receptor signaling pathway	1.936E-03	9.307E-03	MAPK1, NFKB1

Showing 1 to 10 of 27 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
A00-B99: Certain infectious and parasitic diseases	Anthelmintic	B89	ALPL;
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	ABCB1;
C00-D49: Neoplasms	Brain cancer	C71, D33	TERT;
C00-D49: Neoplasms	Chronic lymphocytic leukaemia	C91	BCL2;
C00-D49: Neoplasms	Pancreatic cancer	C25	TERT;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	DNMT1; ABCB1;
C00-D49: Neoplasms	Prostate cancer	C61	TERT; BCL2;
C00-D49: Neoplasms	Tumors	C00-D48	TERT;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Acanthophyllum elatius

Taxonomic Information:

Plant External Links:

Used in Medicines:

Geographical Distribution:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities