CMAUP Plant Collective Molecular Activities

Plant Name: Verbena officinalis

Taxonomic Information:

Plant ID: NPO2838
Plant Latin Name: Verbena officinalis
Taxonomy Genus: Verbena
Taxonomy Family: Verbenaceae

Plant External Links:

NCBI TaxonomyDB: 79772
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Turkey; Israel; Italy; Turkmenistan; Philippines; India; Malaysia; Vietnam; Jordan; China; Laos; Thailand; Spain

Traditional Medicine System:

TCM

Medicinal Functions:

Analgesic; Antibacterial; Anticoagulant; Antipruritic; Antirheumatic; Antispasmodic; Antitumor; Astringent; Bach; Birthing aid; Depurative; Diaphoretic; Diuretic; Emmenagogue; Galactogogue; Stimulant; Tonic; Vulnerary

Geographical Distribution:

Turkey; Israel; Italy; Turkmenistan; Philippines; India; Malaysia; Vietnam; Jordan; Laos; China; Thailand; Spain

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	RECQL; HSD17B1; HSD17B2; NOX4;
Hydrolase	ACHE;
Protein Phosphatase	CDC25B;
Protein Kinase	FLT3; MAPK1; CSNK2A1;
Lyase	CA2; CA12; CA7; CA4;
Nuclear hormone receptor subfamily 1 group F	RORC;
Nuclear hormone receptor subfamily 3 group A	ESR2;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Oxidoreductase	TYR;
Metallo protease	MMP12;
Transcription Factor	AHR; HIF1A;
Methyl-lysine/arginine binding protein	L3MBTL1;
Unclassified	THPO;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP19A1; CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	HSD17B1	Estradiol 17-beta-dehydrogenase 1	P14061	CHEMBL3181
Enzyme_unclassified	HSD17B2	Estradiol 17-beta-dehydrogenase 2	P37059	CHEMBL2789
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Metallo protease	MMP12	Matrix metalloproteinase 12	P39900	CHEMBL4393
Methyl-lysine/arginine binding protein	L3MBTL1	Lethal(3)malignant brain tumor-like protein 1	Q9Y468	CHEMBL1287622
Nuclear hormone receptor subfamily 1 group F	RORC	Nuclear receptor ROR-gamma	P51449	CHEMBL1741186
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Nuclear hormone receptor subfamily 3 group A	ESR2	Estrogen receptor beta	Q92731	CHEMBL242
Oxidoreductase	TYR	Tyrosinase	P14679	CHEMBL1973
Protein Kinase	FLT3	Tyrosine-protein kinase receptor FLT3	P36888	CHEMBL1974
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Protein Kinase	CSNK2A1	Casein kinase II alpha	P68400	CHEMBL3629
Protein Phosphatase	CDC25B	Dual specificity phosphatase Cdc25B	P30305	CHEMBL4804
Transcription Factor	AHR	Aryl hydrocarbon receptor	P35869	CHEMBL3201
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Unclassified	THPO	Thrombopoietin	P40225	CHEMBL1293256

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0019825; oxygen binding	3.461E-09	2.529E-05	CYP19A1, CYP1A1, CYP1A2, CYP1B1, NOX4
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	3.484E-09	2.529E-05	CA12, CA2, CA4, CA7
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	2.244E-08	7.473E-05	CYP19A1, CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.475E-07	2.627E-04	CA12, CA2, CA4, CA7
BP	GO:0050896; response to stimulus	GO:0033993; response to lipid	2.391E-07	3.470E-04	CA2, CSNK2A1, CYP1A1, CYP1A2, FLT3, HSD17B2, NR1H4, RORC, TYR
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	2.582E-07	3.514E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	3.375E-07	3.867E-04	CA12, CA2, CA4, CA7
MF	GO:0140110; transcription regulator activity	GO:0004879; nuclear receptor activity	5.243E-07	4.391E-04	AHR, ESR2, NR1H4, RORC
BP	GO:0008152; metabolic process	GO:0006703; estrogen biosynthetic process	6.137E-07	4.800E-04	CYP19A1, HSD17B1, HSD17B2
MF	GO:0005488; binding	GO:0008270; zinc ion binding	6.496E-07	4.878E-04	CA12, CA2, CA4, CA7, ESR2, L3MBTL1, MMP12, NR1H4, RORC
MF	GO:0005488; binding	GO:0020037; heme binding	6.950E-07	4.882E-04	CYP19A1, CYP1A1, CYP1A2, CYP1B1, NOX4
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	2.833E-06	1.582E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	3.766E-06	1.907E-03	CYP1A1, CYP1A2, CYP1B1
MF	GO:0005488; binding	GO:0005496; steroid binding	5.080E-06	2.354E-03	ESR2, HSD17B1, NR1H4, RORC
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	5.222E-06	2.369E-03	CA2, CA7
BP	GO:0009987; cellular process	GO:0071407; cellular response to organic cyclic compound	5.841E-06	2.544E-03	CYP1A1, CYP1B1, FLT3, MAPK1, NOX4, RORC
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	1.044E-05	4.167E-03	CYP1A1, CYP1A2
MF	GO:0005488; binding	GO:0051879; Hsp90 protein binding	1.046E-05	4.167E-03	AHR, CSNK2A1, HIF1A
BP	GO:0008152; metabolic process	GO:0055114; oxidation-reduction process	1.563E-05	5.770E-03	CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, NOX4, TYR

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.003E-10	1.184E-08	HSD17B1, CYP1A2, HSD17B2, CYP1A1, CYP1B1, CYP19A1
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	5.027E-09	2.076E-07	HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	5.278E-09	2.076E-07	CA12, CA2, CA4, CA7
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	1.866E-05	5.506E-04	CYP1A2, CYP1A1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	8.841E-05	2.087E-03	FLT3, MAPK1, HIF1A
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.142E-04	2.246E-03	CYP1A2, CYP1A1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.613E-04	2.720E-03	CYP1A2, CYP1A1, CYP1B1
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	4.043E-04	5.963E-03	CA2, CA4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1;
NA: NA	Edema	NA	CA2;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE;
NA: NA	GIST	NA	FLT3;
C00-D49: Neoplasms	Glioblastoma	NA	FLT3;
C00-D49: Neoplasms	Gliosarcoma	NA	FLT3;
L00-L99: Diseases of the skin and subcutaneous tissue	Melasma	L81.1	TYR;
C00-D49: Neoplasms	Melanoma	C43	TYR;
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	MMP12;
J00-J99: Diseases of the respiratory system	Asthma	J45	MMP12;
C00-D49: Neoplasms	Solid tumours	C00-D48	FLT3; HIF1A; MAPK1;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ACHE;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
NA: NA	Upper abdominal bloating	NA	ACHE;
C00-D49: Neoplasms	Multiple myeloma	C90	AHR;
C00-D49: Neoplasms	Cancer	C00-C96	CSNK2A1; FLT3; ACHE; HIF1A; MAPK1; CDC25B;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;
C00-D49: Neoplasms	Colon cancer	C50	FLT3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE;
C00-D49: Neoplasms	CLL	NA	FLT3;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	MMP12;
J00-J99: Diseases of the respiratory system	Airway inflammation	J00-J99	FLT3;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	FLT3;
C00-D49: Neoplasms	AML	NA	FLT3;
L00-L99: Diseases of the skin and subcutaneous tissue	Vitiligo	L80	TYR;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4; ACHE; CA2;
NA: NA	Anaplastic mixed oligoastrocytoma	NA	FLT3;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	FLT3;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
C00-D49: Neoplasms	Pancreatic cancer	C25	FLT3;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE;
I00-I99: Diseases of the circulatory system	Aortic aneurysm	I71	MMP12;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	FLT3;
C00-D49: Neoplasms	Leukemia	C90-C95	FLT3;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE;
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1;
C00-D49: Neoplasms	Prostate cancer	C61	FLT3;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
C00-D49: Neoplasms	Myelofibrosis	C94.4, D47.4	FLT3;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A;
C00-D49: Neoplasms	Breast cancer	C50	FLT3; CYP19A1;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	MMP12;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
NA: NA	HIV infections	NA	AHR;
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE;
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1;
NA: NA	Hematopoietic stem cell transplantation	NA	FLT3;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
C00-D49: Neoplasms	Myeloid leukemia	C92	FLT3;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	TYR;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases