Plant ID: NPO28375
Plant Latin Name: Pygeum topengii
Taxonomy Genus: Pygeum
Taxonomy Family: Rosaceae
NCBI TaxonomyDB:
401067
Plant-of-the-World-Online:
n.a.
TDP1; AKR1B1; | |
NR1H4; | |
L3MBTL1; |
Cytochrome P450 Enzymes: |
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Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|
Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
Enzyme_unclassified | AKR1B1 | Aldose reductase | P15121 | CHEMBL1900 |
Methyl-lysine/arginine binding protein | L3MBTL1 | Lethal(3)malignant brain tumor-like protein 1 | Q9Y468 | CHEMBL1287622 |
Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|
MF | GO:0060089; molecular transducer activity | GO:0038181; bile acid receptor activity | 6.212E-04 | 3.559E-01 | NR1H4 |
MF | GO:0060089; molecular transducer activity | GO:0004887; thyroid hormone receptor activity | 1.449E-03 | 6.186E-01 | NR1H4 |
CC | GO:0044464; cell part | GO:0099568; cytoplasmic region | 4.158E-02 | 1.000E+00 | AKR1B1 |
Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|---|
09100 Metabolism | 09101 Carbohydrate metabolism | hsa00040 | Pentose and glucuronate interconversions | 7.181E-03 | 1.436E-02 | AKR1B1 |
09100 Metabolism | 09101 Carbohydrate metabolism | hsa00052 | Galactose metabolism | 5.987E-03 | 1.436E-02 | AKR1B1 |
09100 Metabolism | 09103 Lipid metabolism | hsa00561 | Glycerolipid metabolism | 1.175E-02 | 1.695E-02 | AKR1B1 |
09100 Metabolism | 09101 Carbohydrate metabolism | hsa00051 | Fructose and mannose metabolism | 6.385E-03 | 1.436E-02 | AKR1B1 |
09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 1.413E-02 | 1.695E-02 | NR1H4 |
Unclassified | Unclassified | hsa01100 | Metabolic pathways | 2.257E-01 | 2.257E-01 | AKR1B1 |
ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
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