CMAUP Plant Collective Molecular Activities

Plant Name: Hakea trifurcata

Taxonomic Information:

Plant ID: NPO28314
Plant Latin Name: Hakea trifurcata
Taxonomy Genus: Hakea
Taxonomy Family: Proteaceae

Plant External Links:

NCBI TaxonomyDB: 1136213
Plant-of-the-World-Online: n.a.

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADORA3;
Peptide receptor (family A GPCR)	TSHR;
Protein Phosphatase	PTPN1;
Enzyme_unclassified	BLM;
Ionotropic glutamate receptor	GRIA4; GRIK2; GRIA1; GRIK3; GRIK5; GRIK1;
Methyl-lysine/arginine binding protein	SMN1;SMN2;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Ionotropic glutamate receptor	GRIA4	Glutamate receptor ionotropic, AMPA 4	P48058	CHEMBL3190
Ionotropic glutamate receptor	GRIK2	Glutamate receptor ionotropic kainate 2	Q13002	CHEMBL3683
Ionotropic glutamate receptor	GRIA1	Glutamate receptor ionotropic, AMPA 1	P42261	CHEMBL2009
Ionotropic glutamate receptor	GRIK3	Glutamate receptor ionotropic kainate 3	Q13003	CHEMBL3684
Ionotropic glutamate receptor	GRIK5	Glutamate receptor ionotropic kainate 5	Q16478	CHEMBL2675
Ionotropic glutamate receptor	GRIK1	Glutamate receptor ionotropic kainate 1	P39086	CHEMBL1918
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335
Small molecule receptor (family A GPCR)	ADORA3	Adenosine A3 receptor	P0DMS8	CHEMBL256
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005215; transporter activity	GO:0015277; kainate selective glutamate receptor activity	6.163E-13	1.491E-09	GRIK1, GRIK2, GRIK3, GRIK5
BP	GO:0023052; signaling	GO:0060079; excitatory postsynaptic potential	2.798E-12	5.540E-09	GRIA1, GRIA4, GRIK1, GRIK2, GRIK3, GRIK5
CC	GO:0044464; cell part	GO:0043204; perikaryon	8.490E-09	1.027E-05	GRIK2, GRIK3, GRIK5, SMN1, SMN2
MF	GO:0005215; transporter activity	GO:0008381; mechanosensitive ion channel activity	3.890E-08	3.258E-05	GRIA1, GRIA4, GRIK1, GRIK2, GRIK3, GRIK5
CC	GO:0044456; synapse part	GO:0045211; postsynaptic membrane	1.778E-07	1.335E-04	GRIA4, GRIK1, GRIK2, GRIK3, GRIK5
MF	GO:0005215; transporter activity	GO:0098782; mechanosensitived potassium channel activity	7.897E-07	4.777E-04	GRIK1, GRIK2, GRIK3, GRIK5
CC	GO:0032991; macromolecular complex	GO:0032983; kainate selective glutamate receptor complex	1.254E-06	6.561E-04	GRIK2, GRIK5
MF	Unclassified;	GO:0004872; receptor activity	1.544E-06	7.473E-04	ADORA3, GRIA1, GRIA4, GRIK1, GRIK2, GRIK3, GRIK5, TSHR
MF	GO:0005215; transporter activity	GO:0004971; AMPA glutamate receptor activity	2.507E-06	1.137E-03	GRIA1, GRIA4
CC	GO:0044464; cell part	GO:0043005; neuron projection	6.386E-06	2.528E-03	GRIA1, GRIA4, GRIK3, GRIK5, SMN1, SMN2
CC	GO:0044456; synapse part	GO:0043195; terminal bouton	8.802E-06	3.305E-03	GRIK2, GRIK3, GRIK5
BP	GO:0051179; localization	GO:0034220; ion transmembrane transport	1.130E-05	4.035E-03	GRIA1, GRIA4, GRIK1, GRIK2, GRIK3, GRIK5
MF	GO:0005488; binding	GO:0030165; PDZ domain binding	2.360E-05	8.029E-03	GRIA1, GRIK2, GRIK5
CC	GO:0043226; organelle	GO:0097504; Gemini of coiled bodies	2.749E-05	9.210E-03	SMN1, SMN2
MF	GO:0005215; transporter activity	GO:0005234; extracellularly glutamate-gated ion channel activity	6.433E-16	7.004E-12	GRIA1, GRIA4, GRIK1, GRIK2, GRIK3, GRIK5
BP	GO:0009987; cellular process	GO:0035235; ionotropic glutamate receptor signaling pathway	5.447E-15	3.811E-11	GRIA1, GRIA4, GRIK1, GRIK2, GRIK3, GRIK5
BP	GO:0023052; signaling	GO:0051967; negative regulation of synaptic transmission, glutamatergic	3.788E-05	1.115E-02	GRIK2, GRIK3
BP	GO:0032501; multicellular organismal process	GO:0007399; nervous system development	4.930E-05	1.394E-02	GRIK1, SMN1, SMN2, TSHR

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1.484E-12	3.858E-11	GRIA1, GRIK5, ADORA3, GRIK3, GRIK1, GRIK2, TSHR, GRIA4
09150 Organismal Systems	09156 Nervous system	hsa04724	Glutamatergic synapse	4.988E-11	6.484E-10	GRIA1, GRIK5, GRIK3, GRIK1, GRIK2, GRIA4
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	2.578E-04	1.950E-03	GRIA1, TSHR, GRIA4
09160 Human Diseases	09164 Substance dependence	hsa05033	Nicotine addiction	3.000E-04	1.950E-03	GRIA1, GRIA4
09160 Human Diseases	09164 Substance dependence	hsa05031	Amphetamine addiction	8.420E-04	4.379E-03	GRIA1, GRIA4
09150 Organismal Systems	09159 Environmental adaptation	hsa04713	Circadian entrainment	1.683E-03	7.055E-03	GRIA1, GRIA4
09150 Organismal Systems	09156 Nervous system	hsa04723	Retrograde endocannabinoid signaling	1.899E-03	7.055E-03	GRIA1, GRIA4
09150 Organismal Systems	09156 Nervous system	hsa04728	Dopaminergic synapse	3.074E-03	9.989E-03	GRIA1, GRIA4
09120 Genetic Information Processing	09122 Translation	hsa03013	RNA transport	5.389E-03	1.557E-02	SMN2, SMN1
09120 Genetic Information Processing	09124 Replication and repair	hsa03440	Homologous recombination	1.869E-02	4.860E-02	BLM

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	GRIK1;
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	ADORA3;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ADORA3;
C00-D49: Neoplasms	Cancer	C00-C96	ADORA3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	GRIK1;
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	GRIK1;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ADORA3;
I00-I99: Diseases of the circulatory system	Ischemia	I99.8	ADORA3;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	GRIK1;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	GRIK1;
NA: NA	Hepatitis C virus infection	NA	ADORA3;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ADORA3;
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	ADORA3;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases