Plant Name: Stemona japonica
Taxonomic Information:
Plant ID: NPO28230
Plant Latin Name: Stemona japonica
Taxonomy Genus: Stemona
Taxonomy Family: Stemonaceae
Plant External Links:
NCBI TaxonomyDB:
85282
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| METAP2; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: | CYP2D6; |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 2 | CYP2D6 | Cytochrome P450 2D6 | P10635 | CHEMBL289 |
| Metallo protease | METAP2 | Methionine aminopeptidase 2 | P50579 | CHEMBL3922 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0070988; demethylation | 6.100E-03 | 1.000E+00 | CYP2D6 |
| BP | GO:0008152; metabolic process | GO:0008202; steroid metabolic process | 2.541E-02 | 1.000E+00 | CYP2D6 |
| BP | GO:0065007; biological regulation | GO:0051098; regulation of binding | 3.520E-02 | 1.000E+00 | CYP2D6 |
| MF | GO:0003824; catalytic activity | GO:0070330; aromatase activity | 2.380E-03 | 1.000E+00 | CYP2D6 |
| MF | GO:0003824; catalytic activity | GO:0008395; steroid hydroxylase activity | 3.517E-03 | 1.000E+00 | CYP2D6 |
| MF | GO:0005488; binding | GO:0019825; oxygen binding | 4.654E-03 | 1.000E+00 | CYP2D6 |
| MF | GO:0005488; binding | GO:0020037; heme binding | 1.321E-02 | 1.000E+00 | CYP2D6 |
| MF | GO:0005488; binding | GO:0005506; iron ion binding | 1.650E-02 | 1.000E+00 | CYP2D6 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 6.888E-03 | 1.093E-02 | CYP2D6 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 7.287E-03 | 1.093E-02 | CYP2D6 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 1.117E-02 | 1.117E-02 | CYP2D6 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| E00-E89: Endocrine, nutritional and metabolic diseases | Autoimmune diabetes | E08-E13 | METAP2; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Obesity | E66 | METAP2; |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | METAP2; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
