CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Metallo protease	METAP2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2D6;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Metallo protease	METAP2	Methionine aminopeptidase 2	P50579	CHEMBL3922

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0070988; demethylation	6.100E-03	1.000E+00	CYP2D6
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	2.541E-02	1.000E+00	CYP2D6
BP	GO:0065007; biological regulation	GO:0051098; regulation of binding	3.520E-02	1.000E+00	CYP2D6
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	2.380E-03	1.000E+00	CYP2D6
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	3.517E-03	1.000E+00	CYP2D6
MF	GO:0005488; binding	GO:0019825; oxygen binding	4.654E-03	1.000E+00	CYP2D6
MF	GO:0005488; binding	GO:0020037; heme binding	1.321E-02	1.000E+00	CYP2D6
MF	GO:0005488; binding	GO:0005506; iron ion binding	1.650E-02	1.000E+00	CYP2D6

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	6.888E-03	1.093E-02	CYP2D6
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7.287E-03	1.093E-02	CYP2D6
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	1.117E-02	1.117E-02	CYP2D6

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Solid tumours	C00-D48	METAP2;
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	METAP2;
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	METAP2;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Stemona japonica

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities