CMAUP Plant Collective Molecular Activities

Plant Name: Brachylaena perrieri

Taxonomic Information:

Plant ID: NPO28196
Plant Latin Name: Brachylaena perrieri
Taxonomy Genus: Brachylaena
Taxonomy Family: Asteraceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	FFAR4; FFAR1;
Lyase	CA7; CA4;
Nuclear hormone receptor subfamily 1 group C	PPARA;
Enzyme_unclassified	ALOX15; CBR1;
Unclassified	FABP3; LMNA; FABP5;
Oxidoreductase	XDH;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP1A1; CYP1A2; CYP19A1; CYP2C19;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	CBR1	Carbonyl reductase [NADPH] 1	P16152	CHEMBL5586
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Oxidoreductase	XDH	Xanthine dehydrogenase	P47989	CHEMBL1929
Small molecule receptor (family A GPCR)	FFAR4	G-protein coupled receptor 120	Q5NUL3	CHEMBL5339
Small molecule receptor (family A GPCR)	FFAR1	Free fatty acid receptor 1	O14842	CHEMBL4422
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0005506; iron ion binding	2.520E-11	2.324E-07	ALOX15, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, XDH
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	6.572E-11	3.577E-07	CYP1A1, CYP1A2, CYP1B1, CYP2C19
MF	GO:0005488; binding	GO:0019825; oxygen binding	2.338E-10	6.364E-07	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	1.863E-09	3.120E-06	CYP1A1, CYP1A2, CYP1B1, CYP2C19
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	2.753E-09	4.282E-06	CYP19A1, CYP1A1, CYP1A2, CYP1B1
MF	GO:0005488; binding	GO:0020037; heme binding	4.867E-08	5.299E-05	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19
BP	GO:0008152; metabolic process	GO:0055114; oxidation-reduction process	1.952E-07	1.771E-04	ALOX15, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, XDH
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	8.175E-07	6.593E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	1.278E-06	9.598E-04	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19
MF	GO:0005488; binding	GO:0005504; fatty acid binding	1.347E-06	9.780E-04	FABP3, FABP5, FFAR4
BP	GO:0008152; metabolic process	GO:0016042; lipid catabolic process	1.980E-06	1.270E-03	CYP19A1, CYP1A2, CYP1B1, FABP3, FABP5
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	2.747E-06	1.709E-03	CYP19A1, CYP1A1, CYP2C19
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	3.856E-06	2.269E-03	CYP1A1, CYP1A2
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	9.631E-06	5.377E-03	CYP1A2, CYP2C19
BP	GO:0008152; metabolic process	GO:0050665; hydrogen peroxide biosynthetic process	1.796E-05	9.538E-03	CYP1A1, CYP1A2

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	2.231E-13	1.852E-11	CA12, CA1, CA2, CA4, CA7, CA9
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	9.191E-11	3.814E-09	CYP2C9, CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2.862E-09	5.938E-08	CYP2C9, CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.404E-09	3.883E-08	CYP2C9, CYP1A2, ALOX15, CYP3A4, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	5.223E-08	8.670E-07	CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	1.263E-07	1.748E-06	FABP3, FABP5, PPARG, PPARA, PPARD
Unclassified	Unclassified	hsa01100	Metabolic pathways	5.169E-06	4.767E-05	CYP2C9, CBR1, CYP1A2, ALOX15, CYP1A1, AKR1B1, CYP2C19, CYP3A4, CYP19A1, HSD17B10, XDH
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	4.078E-06	4.767E-05	CYP2C9, CBR1, ALOX15, CYP2C19
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4.931E-06	4.767E-05	CYP2C9, CYP1A2, CYP1A1, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	6.266E-06	5.200E-05	CYP2C9, CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	4.640E-05	3.209E-04	CYP1A2, CYP1A1, CYP1B1
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	9.095E-05	5.807E-04	CYP1A1, CYP1B1, CYP19A1
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	5.973E-04	3.305E-03	CDK6, PPARG, HIF1A, TP53, PPARD
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	2.586E-04	1.533E-03	CA2, CYP3A4, ABCG2
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	9.820E-04	4.794E-03	CYP2C9, ALOX15, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05216	Thyroid cancer	1.173E-03	5.407E-03	PPARG, TP53
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	7.355E-04	3.816E-03	CA2, CA4
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	2.965E-05	2.237E-04	CYP1A2, XDH

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1;
C00-D49: Neoplasms	Breast cancer	C50	CYP19A1;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4;
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	FFAR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	FFAR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	FFAR1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	XDH;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1;
G00-G99: Diseases of the nervous system G00-G99	Encephalopathy	G93.4	XDH;
I00-I99: Diseases of the circulatory system	Heart failure	I50	XDH;
J00-J99: Diseases of the respiratory system	Asthma	J45	CBR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperuricemia	E79.0	XDH;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperuricaemia in gout	E79.0, M10	XDH;
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases