CMAUP Plant Collective Molecular Activities

Plant Name: Consolida oliveriana

Taxonomic Information:

Plant ID: NPO28094
Plant Latin Name: Consolida oliveriana
Taxonomy Genus: Consolida
Taxonomy Family: Ranunculaceae

Plant External Links:

NCBI TaxonomyDB: 984861
Plant-of-the-World-Online: n.a.

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Oxidoreductase	MAOA;
Enzyme_unclassified	AKR1B1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Oxidoreductase	MAOA	Monoamine oxidase A	P21397	CHEMBL1951

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0006584; catecholamine metabolic process	4.841E-06	5.270E-02	AKR1B1, MAOA
MF	GO:0003824; catalytic activity	GO:0008131; primary amine oxidase activity	6.212E-04	6.679E-01	MAOA
CC	GO:0044464; cell part	GO:0099568; cytoplasmic region	2.101E-02	1.000E+00	AKR1B1
CC	GO:0044464; cell part	GO:0005764; lysosome	2.817E-02	1.000E+00	AKR1B1
MF	GO:0003824; catalytic activity	GO:0009055; electron transfer activity	1.115E-02	1.000E+00	AKR1B1
MF	GO:0003824; catalytic activity	GO:0016616; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.228E-02	1.000E+00	AKR1B1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09105 Amino acid metabolism	hsa00340	Histidine metabolism	2.399E-03	7.548E-03	MAOA
09100 Metabolism	09105 Amino acid metabolism	hsa00360	Phenylalanine metabolism	1.699E-03	7.548E-03	MAOA
Unclassified	Unclassified	hsa01100	Metabolic pathways	3.835E-03	7.548E-03	MAOA, AKR1B1
09100 Metabolism	09105 Amino acid metabolism	hsa00350	Tyrosine metabolism	3.497E-03	7.548E-03	MAOA
09100 Metabolism	09101 Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3.597E-03	7.548E-03	AKR1B1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	2.998E-03	7.548E-03	AKR1B1
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	3.996E-03	7.548E-03	MAOA
09100 Metabolism	09101 Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	3.198E-03	7.548E-03	AKR1B1
09100 Metabolism	09105 Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	3.996E-03	7.548E-03	MAOA
09160 Human Diseases	09164 Substance dependence	hsa05031	Amphetamine addiction	6.689E-03	8.364E-03	MAOA
09160 Human Diseases	09164 Substance dependence	hsa05030	Cocaine addiction	4.894E-03	7.718E-03	MAOA
09100 Metabolism	09103 Lipid metabolism	hsa00561	Glycerolipid metabolism	5.891E-03	8.346E-03	AKR1B1
09100 Metabolism	09105 Amino acid metabolism	hsa00330	Arginine and proline metabolism	4.994E-03	7.718E-03	MAOA
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	6.888E-03	8.364E-03	MAOA

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases