Plant Name: Crateva nurvala
Taxonomic Information:
Plant ID: NPO28073
Plant Latin Name: Crateva nurvala
Taxonomy Genus: Crateva
Taxonomy Family: Capparaceae
Plant External Links:
NCBI TaxonomyDB:
1149812
Plant-of-the-World-Online:
n.a.
Geographical Distribution
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−
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| NPSR1; | |
| GPR35; | |
| TDP1; RECQL; HPGD; HSD11B1; AKR1B10; ALOX12; AKR1B1; HSD17B2; HSD17B10; NOX4; APEX1; POLB; | |
| TEK; MET; AXL; KDR; FLT3; CDK1; EGFR; PIM1; INSR; SRC; CSNK2A1; IGF1R; AURKB; NUAK1; | |
| CA2; CA12; CA7; CA4; | |
| RORC; | |
| NR1H4; | |
| KDM4E; | |
| TYR; | |
| AHR; | |
| FUT7; | |
| SLC22A6; | |
| SMAD3; LMNA; APP; HSPA1A; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Enzyme_unclassified | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Enzyme_unclassified | HPGD | 15-hydroxyprostaglandin dehydrogenase [NAD+] | P15428 | CHEMBL1293255 |
| Enzyme_unclassified | HSD11B1 | 11-beta-hydroxysteroid dehydrogenase 1 | P28845 | CHEMBL4235 |
| Enzyme_unclassified | AKR1B10 | Aldo-keto reductase family 1 member B10 | O60218 | CHEMBL5983 |
| Enzyme_unclassified | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Enzyme_unclassified | AKR1B1 | Aldose reductase | P15121 | CHEMBL1900 |
Showing 1 to 10 of 46 entries
Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0009987; cellular process | GO:0043066; negative regulation of apoptotic process | 5.573E-11 | 7.138E-08 | AKR1B1, ALOX12, AURKB, AXL, CDK1, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, LMNA, NR1H4, PIM1, SMAD3, SRC, TEK |
| BP | GO:0008152; metabolic process | GO:0008202; steroid metabolic process | 5.765E-09 | 2.414E-06 | AKR1B1, AKR1B10, APP, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD17B2, NR1H4 |
| BP | GO:0008152; metabolic process | GO:0055114; oxidation-reduction process | 1.189E-08 | 3.924E-06 | AKR1B1, AKR1B10, ALOX12, APEX1, CYP1A1, CYP1A2, CYP1B1, HPGD, HSD11B1, HSD17B10, HSD17B2, KDM4E, NOX4, TYR |
| BP | GO:0009987; cellular process | GO:0051897; positive regulation of protein kinase B signaling | 6.731E-08 | 1.981E-05 | AXL, EGFR, INSR, MET, NOX4, SRC, TEK |
| BP | GO:0008152; metabolic process | GO:0038083; peptidyl-tyrosine autophosphorylation | 8.715E-08 | 2.497E-05 | EGFR, IGF1R, INSR, KDR, SRC |
| BP | GO:0050896; response to stimulus | GO:0009725; response to hormone | 3.060E-07 | 6.940E-05 | AKR1B1, APEX1, CA2, CSNK2A1, CYP1A2, EGFR, FLT3, HPGD, INSR, SRC, TEK |
| BP | GO:0009987; cellular process | GO:0070301; cellular response to hydrogen peroxide | 3.297E-07 | 7.327E-05 | AKR1B1, APEX1, AXL, CDK1, CYP1B1 |
| BP | GO:0032502; developmental process | GO:0031100; animal organ regeneration | 9.972E-07 | 1.905E-04 | AXL, CDK1, CSNK2A1, EGFR, FLT3 |
| BP | GO:0008152; metabolic process | GO:0097267; omega-hydroxylase P450 pathway | 1.499E-06 | 2.698E-04 | CYP1A1, CYP1A2, CYP1B1 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 1.568E-06 | 2.798E-04 | CA12, CA2, CA4, CA7 |
Showing 1 to 10 of 58 entries
Enriched KEGG Pathways of Target Proteins (Activity≤1μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09103 Lipid metabolism | hsa00140 | Steroid hormone biosynthesis | 2.152E-07 | 6.780E-06 | HSD11B1, CYP1A2, HSD17B2, CYP1A1, CYP1B1 |
| 09100 Metabolism | 09102 Energy metabolism | hsa00910 | Nitrogen metabolism | 5.701E-08 | 3.592E-06 | CA12, CA2, CA4, CA7 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 2.373E-05 | 3.738E-04 | HSD11B1, CYP1A2, CYP1A1, CYP1B1 |
| 09100 Metabolism | 09105 Amino acid metabolism | hsa00380 | Tryptophan metabolism | 1.060E-04 | 1.027E-03 | CYP1A2, CYP1A1, CYP1B1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04015 | Rap1 signaling pathway | 4.972E-07 | 1.253E-05 | SRC, INSR, KDR, TEK, MET, EGFR, IGF1R |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04014 | Ras signaling pathway | 1.283E-05 | 2.309E-04 | INSR, KDR, TEK, MET, EGFR, IGF1R |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04151 | PI3K-Akt signaling pathway | 1.239E-04 | 1.115E-03 | INSR, KDR, TEK, MET, EGFR, IGF1R |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04066 | HIF-1 signaling pathway | 9.167E-05 | 1.027E-03 | INSR, TEK, EGFR, IGF1R |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04068 | FoxO signaling pathway | 2.456E-04 | 2.063E-03 | SMAD3, INSR, EGFR, IGF1R |
| 09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04520 | Adherens junction | 3.386E-10 | 4.266E-08 | SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R |
Showing 1 to 10 of 24 entries
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| A00-B99: Certain infectious and parasitic diseases | Cryptosporidium infection | A07.2 | EGFR; |
| A00-B99: Certain infectious and parasitic diseases | Human immunodeficiency virus infection | B20-B26 | FLT3; |
| C00-D49: Neoplasms | Metastatic castration-resistant prostate cancer | C61 | KDR; |
| C00-D49: Neoplasms | Osteosarcoma | C40-C41 | SRC; |
| C00-D49: Neoplasms | Ovarian cancer | C56 | KDR; EGFR; |
| C00-D49: Neoplasms | Pancreatic cancer | C25 | KDR; FLT3; EGFR; |
| C00-D49: Neoplasms | Peritoneal cavity cancer | NA | KDR; |
| C00-D49: Neoplasms | Squamous cell cancer of head and neck | NA | KDR; |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | MET; AURKB; IGF1R; KDR; FLT3; TEK; EGFR; SRC; |
| C00-D49: Neoplasms | Lung cancer | C33-C34 | EGFR; |
Showing 1 to 10 of 136 entries
>> Profiles of ingredients and activity landscape
>> Collective molecular activities profile at 10μM cutoff
>> Targets derived from weak experimental activities
