CMAUP Plant Collective Molecular Activities

Plant Name: Piper callosum

Taxonomic Information:

Plant ID: NPO28049
Plant Latin Name: Piper callosum
Taxonomy Genus: Piper
Taxonomy Family: Piperaceae

Plant External Links:

NCBI TaxonomyDB: 538245
Plant-of-the-World-Online: 680748-1

Used in Medicines:

Country/Region:

Brazil; Bolivia

Traditional Medicine System:

Geographical Distribution:

Brazil; Bolivia; Peru

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Taste receptor (taste family GPCR)	TAS2R31;
Peptide receptor (family A GPCR)	TSHR;
SLC superfamily of solute carriers	SLCO1B3; SLCO1B1;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP1A1; CYP1A2; CYP19A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
SLC superfamily of solute carriers	SLCO1B3	Solute carrier organic anion transporter family member 1B3	Q9NPD5	CHEMBL1743121
SLC superfamily of solute carriers	SLCO1B1	Solute carrier organic anion transporter family member 1B1	Q9Y6L6	CHEMBL1697668
Taste receptor (taste family GPCR)	TAS2R31	Taste receptor type 2 member 31	P59538	CHEMBL2034804
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	1.917E-10	3.521E-06	CYP19A1, CYP1A1, CYP1A2, CYP1B1
MF	GO:0005488; binding	GO:0019825; oxygen binding	3.210E-09	2.330E-05	CYP19A1, CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	8.380E-09	4.562E-05	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	9.264E-08	3.362E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	1.233E-07	3.834E-04	CYP1A1, CYP1A2, CYP1B1
MF	GO:0005488; binding	GO:0020037; heme binding	2.259E-07	5.466E-04	CYP19A1, CYP1A1, CYP1A2, CYP1B1
MF	GO:0005488; binding	GO:0005506; iron ion binding	5.531E-07	1.004E-03	CYP19A1, CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	1.157E-06	1.939E-03	CYP1A1, CYP1A2
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	3.127E-06	4.255E-03	CYP19A1, CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0050665; hydrogen peroxide biosynthetic process	5.396E-06	6.911E-03	CYP1A1, CYP1A2
MF	GO:0005215; transporter activity	GO:0015125; bile acid transmembrane transporter activity	2.941E-05	2.372E-02	SLCO1B1, SLCO1B3
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	7.072E-05	4.154E-02	SLCO1B1, SLCO1B3, TSHR
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	5.336E-04	1.905E-01	CYP19A1, CYP1A1, CYP1A2, CYP1B1
CC	GO:0044425; membrane part	GO:0005887; integral component of plasma membrane	2.331E-02	1.000E+00	SLCO1B1, SLCO1B3, TSHR
CC	GO:0016020; membrane	GO:0031090; organelle membrane	2.728E-02	1.000E+00	CYP1A1, CYP1A2, CYP1B1, LMNA

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	7.935E-09	1.746E-07	CYP1A2, CYP1A1, CYP1B1, CYP19A1
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	6.174E-07	6.791E-06	CYP1A2, CYP1A1, CYP1B1
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	1.222E-06	8.961E-06	CYP1A1, CYP1B1, CYP19A1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3.858E-06	2.122E-05	CYP1A2, CYP1A1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	5.482E-06	2.412E-05	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3.690E-04	1.353E-03	CYP1A2, CYP1A1
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	4.402E-04	1.383E-03	SLCO1B1, SLCO1B3
Unclassified	Unclassified	hsa01100	Metabolic pathways	1.502E-02	3.305E-02	CYP1A2, CYP1A1, CYP19A1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.298E-02	3.172E-02	CYP1A2
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	2.248E-03	6.183E-03	CYP1A2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;
C00-D49: Neoplasms	Breast cancer	C50	CYP19A1;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1;
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1;
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1;
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases