CMAUP Plant Collective Molecular Activities

Plant Name: Streblus asper

Taxonomic Information:

Plant ID: NPO28043
Plant Latin Name: Streblus asper
Taxonomy Genus: Streblus
Taxonomy Family: Moraceae

Plant External Links:

NCBI TaxonomyDB: 648879
Plant-of-the-World-Online: 856662-1

Used in Medicines:

Country/Region:

Thailand; India

Traditional Medicine System:

Geographical Distribution:

Pakistan; Bangladesh; Myanmar; India; Cambodia; Vietnam; Laos; Sri Lanka; Thailand

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	CNR1; CNR2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Small molecule receptor (family A GPCR)	CNR1	Cannabinoid CB1 receptor	P21554	CHEMBL218
Small molecule receptor (family A GPCR)	CNR2	Cannabinoid CB2 receptor	P34972	CHEMBL253

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0038171; cannabinoid signaling pathway	3.216E-08	3.502E-04	CNR1, CNR2
MF	GO:0060089; molecular transducer activity	GO:0004949; cannabinoid receptor activity	1.608E-08	3.502E-04	CNR1, CNR2
BP	GO:0008152; metabolic process	GO:0051001; negative regulation of nitric-oxide synthase activity	1.126E-07	8.171E-04	CNR1, CNR2
BP	GO:0002376; immune system process	GO:0033004; negative regulation of mast cell activation	2.948E-07	1.284E-03	CNR1, CNR2
BP	GO:0065007; biological regulation	GO:0045759; negative regulation of action potential	3.538E-07	1.284E-03	CNR1, CNR2
BP	GO:0023052; signaling	GO:0032228; regulation of synaptic transmission, GABAergic	2.659E-06	7.237E-03	CNR1, CNR2
CC	GO:0044464; cell part	GO:0042995; cell projection	5.160E-03	1.000E+00	CNR1, CNR2
CC	GO:0044464; cell part	GO:0030424; axon	2.643E-02	1.000E+00	CNR1
CC	GO:0044456; synapse part	GO:0097060; synaptic membrane	2.950E-02	1.000E+00	CNR1
CC	GO:0016020; membrane	GO:0045121; membrane raft	3.011E-02	1.000E+00	CNR1
CC	GO:0044464; cell part	GO:0030425; dendrite	3.428E-02	1.000E+00	CNR2
MF	Unclassified;	GO:0004872; receptor activity	6.477E-03	1.000E+00	CNR1, CNR2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1.911E-04	5.734E-04	CNR2, CNR1
09150 Organismal Systems	09156 Nervous system	hsa04723	Retrograde endocannabinoid signaling	1.007E-02	1.511E-02	CNR1
09130 Environmental Information Processing	09132 Signal transduction	hsa04015	Rap1 signaling pathway	2.099E-02	2.099E-02	CNR1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases