CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Protein Phosphatase	CDC25B;
Enzyme_unclassified	RECQL; NOX4; HSD17B1; HSD11B1;
Hydrolase	ACHE;
Protein Kinase	CSNK2A1; FLT3;
Lyase	CA7; CA4; CA12;
Nuclear hormone receptor subfamily 3 group A	ESR2;
Nuclear hormone receptor subfamily 1 group F	RORC;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Metallo protease	MMP12;
Transcription Factor	HIF1A;
Unclassified	THPO;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP1A1; CYP1A2; CYP19A1;

Detailed Information of Target Proteins

Show entries

Search:

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Enzyme_unclassified	HSD17B1	Estradiol 17-beta-dehydrogenase 1	P14061	CHEMBL3181
Enzyme_unclassified	HSD11B1	11-beta-hydroxysteroid dehydrogenase 1	P28845	CHEMBL4235
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326

Showing 1 to 10 of 21 entries

Previous1 2 3Next

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Show entries

Search:

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	1.322E-07	3.600E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	1.454E-06	2.639E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	1.934E-06	2.829E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	6.746E-06	5.649E-03	CYP1A1, CYP1A2
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	7.727E-06	5.875E-03	CA12, CA4, CA7
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.080E-09	2.351E-05	CYP19A1, CYP1A1, CYP1A2, CYP1B1, NOX4
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	9.018E-09	4.909E-05	CYP19A1, CYP1A1, CYP1A2, CYP1B1
MF	GO:0005488; binding	GO:0020037; heme binding	2.208E-07	5.341E-04	CYP19A1, CYP1A1, CYP1A2, CYP1B1, NOX4
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	4.997E-07	9.891E-04	CA12, CA4, CA7
MF	GO:0005488; binding	GO:0005496; steroid binding	2.069E-06	2.829E-03	ESR2, HSD17B1, NR1H4, RORC

Showing 1 to 10 of 10 entries

Previous1Next

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Show entries

Search:

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2.391E-11	1.052E-09	HSD11B1, HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP19A1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	9.326E-07	1.026E-05	HSD11B1, CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	9.614E-06	7.050E-05	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	6.720E-07	9.856E-06	CA12, CA4, CA7
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	2.004E-07	4.410E-06	HSD17B1, CYP1A1, CYP1B1, CYP19A1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.489E-06	1.311E-05	HSD11B1, CYP1A2, CYP1A1, CYP1B1

Showing 1 to 6 of 6 entries

Previous1Next

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

Show entries

Search:

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
C00-D49: Neoplasms	Breast cancer	C50	FLT3; CYP19A1;
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1;
C00-D49: Neoplasms	Solid tumours	C00-D48	FLT3; HIF1A;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	FLT3;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3;
C00-D49: Neoplasms	Leukemia	C90-C95	FLT3;
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;

Showing 1 to 10 of 65 entries

Previous1 2 3 4 5 6 7Next

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Acer triflorum

Taxonomic Information:

Plant External Links:

Used in Medicines:

Geographical Distribution:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities