GPBAR1; | |
PTPN1; PTPN2; CDC25B; | |
TDP1; PLA2G1B; AKR1B10; POLB; | |
NR1H4; |
Cytochrome P450 Enzymes: |
---|
Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|
Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
Enzyme_unclassified | PLA2G1B | Phospholipase A2 group 1B | P04054 | CHEMBL4426 |
Enzyme_unclassified | AKR1B10 | Aldo-keto reductase family 1 member B10 | O60218 | CHEMBL5983 |
Enzyme_unclassified | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
Protein Phosphatase | PTPN1 | Protein-tyrosine phosphatase 1B | P18031 | CHEMBL335 |
Protein Phosphatase | PTPN2 | T-cell protein-tyrosine phosphatase | P17706 | CHEMBL3807 |
Protein Phosphatase | CDC25B | Dual specificity phosphatase Cdc25B | P30305 | CHEMBL4804 |
Small molecule receptor (family A GPCR) | GPBAR1 | G-protein coupled bile acid receptor 1 | Q8TDU6 | CHEMBL5409 |
GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|
BP | GO:0009987; cellular process | GO:0038183; bile acid signaling pathway | 5.788E-07 | 6.302E-03 | GPBAR1, NR1H4 |
BP | GO:0009987; cellular process | GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway | 1.157E-06 | 6.940E-03 | PTPN1, PTPN2 |
BP | GO:0050896; response to stimulus | GO:0046626; regulation of insulin receptor signaling pathway | 1.275E-06 | 6.940E-03 | NR1H4, PTPN1, PTPN2 |
BP | GO:0008152; metabolic process | GO:0016311; dephosphorylation | 5.440E-06 | 1.974E-02 | CDC25B, POLB, PTPN1, PTPN2 |
BP | GO:0009987; cellular process | GO:1903897; regulation of PERK-mediated unfolded protein response | 8.667E-06 | 2.323E-02 | PTPN1, PTPN2 |
BP | GO:0008152; metabolic process | GO:0035335; peptidyl-tyrosine dephosphorylation | 1.073E-05 | 2.323E-02 | CDC25B, PTPN1, PTPN2 |
MF | GO:0003824; catalytic activity | GO:0004725; protein tyrosine phosphatase activity | 1.174E-05 | 2.323E-02 | CDC25B, PTPN1, PTPN2 |
BP | GO:0009987; cellular process | GO:1900103; positive regulation of endoplasmic reticulum unfolded protein response | 1.501E-05 | 2.515E-02 | PTPN1, PTPN2 |
MF | GO:0003824; catalytic activity | GO:0042578; phosphoric ester hydrolase activity | 1.482E-05 | 2.515E-02 | CDC25B, PTPN1, PTPN2, TDP1 |
BP | GO:0009987; cellular process | GO:0010804; negative regulation of tumor necrosis factor-mediated signaling pathway | 3.651E-05 | 5.678E-02 | NR1H4, PTPN2 |
CC | GO:0044464; cell part | GO:0097443; sorting endosome | 2.793E-03 | 4.538E-01 | PTPN1 |
CC | GO:0043226; organelle | GO:0005876; spindle microtubule | 2.443E-02 | 1.000E+00 | POLB |
CC | GO:0043226; organelle | GO:0005654; nucleoplasm | 3.886E-02 | 1.000E+00 | CDC25B, NR1H4, POLB, PTPN2 |
CC | GO:0044464; cell part | GO:0005829; cytosol | 4.929E-02 | 1.000E+00 | AKR1B10, CDC25B, PLA2G1B, PTPN1, PTPN2 |
Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|---|
09100 Metabolism | 09103 Lipid metabolism | hsa00592 | alpha-Linolenic acid metabolism | 1.120E-02 | 6.524E-02 | PLA2G1B |
09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 1.298E-02 | 6.524E-02 | PLA2G1B |
09100 Metabolism | 09101 Carbohydrate metabolism | hsa00040 | Pentose and glucuronate interconversions | 1.609E-02 | 6.524E-02 | AKR1B10 |
09100 Metabolism | 09101 Carbohydrate metabolism | hsa00052 | Galactose metabolism | 1.342E-02 | 6.524E-02 | AKR1B10 |
09100 Metabolism | 09101 Carbohydrate metabolism | hsa00051 | Fructose and mannose metabolism | 1.431E-02 | 6.524E-02 | AKR1B10 |
09150 Organismal Systems | 09154 Digestive system | hsa04975 | Fat digestion and absorption | 1.830E-02 | 6.524E-02 | PLA2G1B |
09120 Genetic Information Processing | 09124 Replication and repair | hsa03410 | Base excision repair | 1.476E-02 | 6.524E-02 | POLB |
09100 Metabolism | 09103 Lipid metabolism | hsa00565 | Ether lipid metabolism | 2.007E-02 | 6.524E-02 | PLA2G1B |
09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04520 | Adherens junction | 3.282E-02 | 7.111E-02 | PTPN1 |
09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 3.151E-02 | 7.111E-02 | NR1H4 |
ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
---|---|---|---|
C00-D49: Neoplasms | Cancer | C00-C96 | CDC25B; |