CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADORA3; ADORA2A; ADORA1;
Peptide receptor (family A GPCR)	NPSR1;
Protein Kinase	MET; AXL; FLT3; CDK1; PIM1; KDR; IGF1R; AURKB;
Enzyme_unclassified	ADK; ALOX12; HSD17B10; NOX4; POLB;
Lyase	CA2; CA12; CA9; CA14; CA7; CA4;
SLC superfamily of solute carriers	SLCO1B1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Enzyme_unclassified	ADK	Adenosine kinase	P55263	CHEMBL3589
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.680E-11	1.219E-07	CA12, CA14, CA2, CA4, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	8.707E-10	3.792E-06	CA12, CA2, CA4, CA7, CA9
BP	GO:0009987; cellular process	GO:0001973; adenosine receptor signaling pathway	1.600E-07	2.050E-04	ADORA1, ADORA2A, ADORA3
BP	Unclassified;	GO:2000021; regulation of ion homeostasis	2.166E-07	2.620E-04	ADORA1, ADORA2A, CA2, CA7, KDR, NPSR1
BP	GO:0023052; signaling	GO:0032230; positive regulation of synaptic transmission, GABAergic	5.431E-07	4.730E-04	ADORA2A, CA2, CA7
BP	GO:0009987; cellular process	GO:0043066; negative regulation of apoptotic process	6.869E-07	5.641E-04	ADORA1, ADORA2A, ALOX12, AURKB, AXL, CDK1, IGF1R, KDR, PIM1
BP	GO:0008283; cell proliferation	GO:0042127; regulation of cell proliferation	2.297E-06	1.389E-03	ADORA1, ADORA2A, ADORA3, ALOX12, CDK1, CYP1B1, FLT3, IGF1R, KDR, NOX4, PIM1
BP	GO:0008152; metabolic process	GO:0018108; peptidyl-tyrosine phosphorylation	3.565E-06	1.848E-03	AXL, FLT3, IGF1R, KDR, MET
BP	GO:0008152; metabolic process	GO:0046777; protein autophosphorylation	4.604E-06	2.048E-03	AURKB, FLT3, IGF1R, KDR, PIM1
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	4.821E-06	2.048E-03	CA2, CA7

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	2.446E-14	1.736E-12	CA12, CA2, CA4, CA7, CA9, CA14
09130 Environmental Information Processing	09132 Signal transduction	hsa04015	Rap1 signaling pathway	1.280E-04	4.544E-03	ADORA2A, KDR, MET, IGF1R
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3.735E-04	8.839E-03	CA2, CA4

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ADORA3;
A00-B99: Certain infectious and parasitic diseases	Sepsis	A40, A41	ADORA1;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR;
C00-D49: Neoplasms	Malignant adrenal gland cancer	C74.0	IGF1R;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MET; IGF1R; KDR; AXL;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	KDR;
C00-D49: Neoplasms	Liver cancer	C22	IGF1R; KDR;
C00-D49: Neoplasms	Melanoma	C43	KDR;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Solanum nigrum linn

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities