CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Nuclear hormone receptor subfamily 1 group A	THRB;
Enzyme_unclassified	ALOX15;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4; CYP2C19;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Nuclear hormone receptor subfamily 1 group A	THRB	Thyroid hormone receptor beta-1	P10828	CHEMBL1947
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Showing 1 to 6 of 6 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.205E-06	2.625E-02	CYP2C19, CYP3A4
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	5.300E-06	5.770E-02	CYP2C19, CYP3A4
BP	GO:0008152; metabolic process	GO:0019369; arachidonic acid metabolic process	1.142E-04	3.757E-01	ALOX15, CYP2C19
BP	GO:0008152; metabolic process	GO:2001303; lipoxin A4 biosynthetic process	6.212E-04	3.757E-01	ALOX15
BP	GO:0009987; cellular process	GO:0038194; thyroid-stimulating hormone signaling pathway	6.212E-04	3.757E-01	TSHR
CC	GO:0043226; organelle	GO:0016604; nuclear body	1.854E-02	1.000E+00	LMNA, THRB
CC	GO:0044464; cell part	GO:0031234; extrinsic component of cytoplasmic side of plasma membrane	2.216E-02	1.000E+00	ALOX15
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	2.997E-02	1.000E+00	CYP2C19, CYP3A4
CC	GO:0016020; membrane	GO:0031090; organelle membrane	3.989E-02	1.000E+00	CYP2C19, CYP3A4, LMNA
CC	GO:0044464; cell part	GO:0005635; nuclear envelope	4.958E-02	1.000E+00	LMNA

Showing 1 to 10 of 13 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	5.466E-08	1.148E-06	ALOX15, CYP3A4, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	1.407E-04	1.221E-03	ALOX15, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.744E-04	1.221E-03	CYP3A4, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1.372E-02	2.887E-02	CYP3A4
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	2.764E-03	9.672E-03	THRB, TSHR
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	4.594E-04	1.930E-03	ALOX15, CYP2C19
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1.668E-02	2.887E-02	TSHR
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	2.464E-04	1.294E-03	CYP3A4, CYP2C19
09160 Human Diseases	09165 Cardiovascular diseases	hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	2.200E-02	2.887E-02	LMNA
Unclassified	Unclassified	hsa01100	Metabolic pathways	4.116E-03	1.235E-02	ALOX15, CYP2C19, CYP3A4

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Achillea moschata

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities