Plant Name: Achillea moschata
Taxonomic Information:
Plant ID: NPO27984
Plant Latin Name: Achillea moschata
Taxonomy Genus: Achillea
Taxonomy Family: Asteraceae
Plant External Links:
NCBI TaxonomyDB:
282750
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TSHR; | |
| THRB; | |
| ALOX15; | |
| LMNA; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
| Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
| Nuclear hormone receptor subfamily 1 group A | THRB | Thyroid hormone receptor beta-1 | P10828 | CHEMBL1947 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 1.205E-06 | 2.625E-02 | CYP2C19, CYP3A4 |
| BP | GO:0050896; response to stimulus | GO:0042738; exogenous drug catabolic process | 5.300E-06 | 5.770E-02 | CYP2C19, CYP3A4 |
| MF | GO:0005488; binding | GO:0005506; iron ion binding | 1.095E-05 | 7.950E-02 | ALOX15, CYP2C19, CYP3A4 |
| MF | GO:0005488; binding | GO:0019825; oxygen binding | 7.913E-05 | 3.446E-01 | CYP2C19, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0019369; arachidonic acid metabolic process | 1.142E-04 | 3.757E-01 | ALOX15, CYP2C19 |
| BP | GO:0008152; metabolic process | GO:2001303; lipoxin A4 biosynthetic process | 6.212E-04 | 3.757E-01 | ALOX15 |
| BP | GO:0009987; cellular process | GO:0038194; thyroid-stimulating hormone signaling pathway | 6.212E-04 | 3.757E-01 | TSHR |
| MF | GO:0003824; catalytic activity | GO:0047977; hepoxilin-epoxide hydrolase activity | 6.212E-04 | 3.757E-01 | ALOX15 |
| CC | GO:0043226; organelle | GO:0016604; nuclear body | 1.854E-02 | 1.000E+00 | LMNA, THRB |
| CC | GO:0044464; cell part | GO:0031234; extrinsic component of cytoplasmic side of plasma membrane | 2.216E-02 | 1.000E+00 | ALOX15 |
| CC | GO:0016020; membrane | GO:0005789; endoplasmic reticulum membrane | 2.997E-02 | 1.000E+00 | CYP2C19, CYP3A4 |
| CC | GO:0016020; membrane | GO:0031090; organelle membrane | 3.989E-02 | 1.000E+00 | CYP2C19, CYP3A4, LMNA |
| CC | GO:0044464; cell part | GO:0005635; nuclear envelope | 4.958E-02 | 1.000E+00 | LMNA |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 5.466E-08 | 1.148E-06 | ALOX15, CYP3A4, CYP2C19 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00590 | Arachidonic acid metabolism | 1.407E-04 | 1.221E-03 | ALOX15, CYP2C19 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 1.744E-04 | 1.221E-03 | CYP3A4, CYP2C19 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 4.594E-04 | 1.930E-03 | ALOX15, CYP2C19 |
| 09160 Human Diseases | 09161 Cancers | hsa05204 | Chemical carcinogenesis | 2.464E-04 | 1.294E-03 | CYP3A4, CYP2C19 |
| 09130 Environmental Information Processing | 09133 Signaling molecules and interaction | hsa04080 | Neuroactive ligand-receptor interaction | 2.764E-03 | 9.672E-03 | THRB, TSHR |
| Unclassified | Unclassified | hsa01100 | Metabolic pathways | 4.116E-03 | 1.235E-02 | ALOX15, CYP2C19, CYP3A4 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00983 | Drug metabolism - other enzymes | 1.372E-02 | 2.887E-02 | CYP3A4 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04923 | Regulation of lipolysis in adipocytes | 1.668E-02 | 2.887E-02 | TSHR |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 2.200E-02 | 2.887E-02 | LMNA |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
