Plant Name: Crossosoma bigelovii
Taxonomic Information:
Plant ID: NPO27978
Plant Latin Name: Crossosoma bigelovii
Taxonomy Genus: Crossosoma
Taxonomy Family: Crossosomataceae
Plant External Links:
NCBI TaxonomyDB:
105808
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TP53; | |
| NPC1; RAB9A; PAX8; | |
| SMN1;SMN2; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Methyl-lysine/arginine binding protein | SMN1;SMN2 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
| Transcription Factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
| Unclassified | NPC1 | Niemann-Pick C1 protein | O15118 | CHEMBL1293277 |
| Unclassified | RAB9A | Ras-related protein Rab-9A | P51151 | CHEMBL1293294 |
| Unclassified | PAX8 | Paired box protein Pax-8 | Q06710 | CHEMBL2362980 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0009987; cellular process | GO:0060548; negative regulation of cell death | 1.114E-03 | 6.260E-01 | NPC1, PAX8, TP53 |
| MF | GO:0005488; binding | GO:0001046; core promoter sequence-specific DNA binding | 3.294E-04 | 6.260E-01 | PAX8, TP53 |
| MF | GO:0060089; molecular transducer activity | GO:0004996; thyroid-stimulating hormone receptor activity | 5.177E-04 | 6.260E-01 | PAX8 |
| MF | GO:0005488; binding | GO:0097371; MDM2/MDM4 family protein binding | 1.811E-03 | 6.918E-01 | TP53 |
| CC | GO:0044464; cell part | GO:0005764; lysosome | 1.949E-03 | 6.932E-01 | NPC1, RAB9A |
| MF | GO:0140110; transcription regulator activity | GO:0001228; transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | 4.287E-03 | 7.975E-01 | PAX8, TP53 |
| MF | GO:0005488; binding | GO:0035035; histone acetyltransferase binding | 6.970E-03 | 9.367E-01 | TP53 |
| MF | GO:0005488; binding | GO:0051721; protein phosphatase 2A binding | 7.228E-03 | 9.367E-01 | TP53 |
| CC | GO:0044464; cell part | GO:0005783; endoplasmic reticulum | 2.162E-02 | 1.000E+00 | NPC1, TP53 |
| CC | GO:0043226; organelle | GO:0042470; melanosome | 2.587E-02 | 1.000E+00 | RAB9A |
| CC | GO:0032991; macromolecular complex | GO:0090575; RNA polymerase II transcription factor complex | 3.346E-02 | 1.000E+00 | TP53 |
| CC | GO:0044464; cell part | GO:0005770; late endosome | 3.446E-02 | 1.000E+00 | RAB9A |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09160 Human Diseases | 09161 Cancers | hsa05216 | Thyroid cancer | 2.025E-05 | 7.694E-04 | PAX8, TP53 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05162 | Measles | 4.529E-04 | 8.605E-03 | RAB9A, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05202 | Transcriptional misregulation in cancer | 7.913E-04 | 1.002E-02 | PAX8, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05200 | Pathways in cancer | 3.778E-03 | 3.589E-02 | PAX8, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05212 | Pancreatic cancer | 1.639E-02 | 4.050E-02 | TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05230 | Central carbon metabolism in cancer | 1.664E-02 | 4.050E-02 | TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05218 | Melanoma | 1.763E-02 | 4.050E-02 | TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05220 | Chronic myeloid leukemia | 1.812E-02 | 4.050E-02 | TP53 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04918 | Thyroid hormone synthesis | 1.763E-02 | 4.050E-02 | PAX8 |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04115 | p53 signaling pathway | 1.713E-02 | 4.050E-02 | TP53 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | TP53; |
| H60-H95: Diseases of the ear and mastoid process | Hearing disorder | H90.5 | TP53; |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Toxicity | T36-T50, T51-T65 | TP53; |
| C00-D49: Neoplasms | Late-stage solid tumors | C00-C75, C7A, C7B, D10-D36, D3A | TP53; |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | TP53; |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | TP53; |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | TP53; |
| G00-G99: Diseases of the nervous system G00-G99 | Spinal muscular atrophy | G00-G99 | SMN1;SMN2; |
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | TP53; |
| C00-D49: Neoplasms | Cancer | C00-C96 | TP53; |
| I00-I99: Diseases of the circulatory system | Renal artery disease | I70.1 | TP53; |
| C00-D49: Neoplasms | Oral cavity cancer | C00-C08 | TP53; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
