CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Transcription Factor	TP53;
Unclassified	NPC1; RAB9A; PAX8;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294
Unclassified	PAX8	Paired box protein Pax-8	Q06710	CHEMBL2362980

Showing 1 to 5 of 5 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0060548; negative regulation of cell death	1.114E-03	6.260E-01	NPC1, PAX8, TP53
CC	GO:0044464; cell part	GO:0005764; lysosome	1.949E-03	6.932E-01	NPC1, RAB9A
CC	GO:0044464; cell part	GO:0005783; endoplasmic reticulum	2.162E-02	1.000E+00	NPC1, TP53
CC	GO:0043226; organelle	GO:0042470; melanosome	2.587E-02	1.000E+00	RAB9A
CC	GO:0032991; macromolecular complex	GO:0090575; RNA polymerase II transcription factor complex	3.346E-02	1.000E+00	TP53
CC	GO:0044464; cell part	GO:0005770; late endosome	3.446E-02	1.000E+00	RAB9A
MF	GO:0005488; binding	GO:0001046; core promoter sequence-specific DNA binding	3.294E-04	6.260E-01	PAX8, TP53
MF	GO:0060089; molecular transducer activity	GO:0004996; thyroid-stimulating hormone receptor activity	5.177E-04	6.260E-01	PAX8
MF	GO:0005488; binding	GO:0097371; MDM2/MDM4 family protein binding	1.811E-03	6.918E-01	TP53
MF	GO:0140110; transcription regulator activity	GO:0001228; transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding	4.287E-03	7.975E-01	PAX8, TP53

Showing 1 to 10 of 12 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09140 Cellular Processes	09143 Cell growth and death	hsa04115	p53 signaling pathway	1.713E-02	4.050E-02	TP53
09150 Organismal Systems	09152 Endocrine system	hsa04918	Thyroid hormone synthesis	1.763E-02	4.050E-02	PAX8
09160 Human Diseases	09161 Cancers	hsa05216	Thyroid cancer	2.025E-05	7.694E-04	PAX8, TP53
09160 Human Diseases	09167 Infectious diseases	hsa05162	Measles	4.529E-04	8.605E-03	RAB9A, TP53
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	7.913E-04	1.002E-02	PAX8, TP53
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	3.778E-03	3.589E-02	PAX8, TP53
09160 Human Diseases	09161 Cancers	hsa05212	Pancreatic cancer	1.639E-02	4.050E-02	TP53
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	1.664E-02	4.050E-02	TP53
09160 Human Diseases	09161 Cancers	hsa05218	Melanoma	1.763E-02	4.050E-02	TP53
09160 Human Diseases	09161 Cancers	hsa05220	Chronic myeloid leukemia	1.812E-02	4.050E-02	TP53

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	TP53;
C00-D49: Neoplasms	Solid tumours	C00-D48	TP53;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53;
C00-D49: Neoplasms	Cancer	C00-C96	TP53;
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53;
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2;
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53;

Showing 1 to 10 of 12 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Crossosoma bigelovii

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities