Plant Name: Simaba cuneata
Taxonomic Information:
Plant ID: NPO27973
Plant Latin Name: Simaba cuneata
Taxonomy Genus: Simaba
Taxonomy Family: Simaroubaceae
Plant External Links:
NCBI TaxonomyDB:
459149
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TSHR; | |
| CA2; CA3; CA1; CA7; CA5A; CA6; CA12; CA14; CA9; | |
| NFKB1; | |
| LMNA; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
| Lyase | CA3 | Carbonic anhydrase III | P07451 | CHEMBL2885 |
| Lyase | CA1 | Carbonic anhydrase I | P00915 | CHEMBL261 |
| Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
| Lyase | CA5A | Carbonic anhydrase VA | P35218 | CHEMBL4789 |
| Lyase | CA6 | Carbonic anhydrase VI | P23280 | CHEMBL3025 |
| Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Lyase | CA14 | Carbonic anhydrase XIV | Q9ULX7 | CHEMBL3510 |
| Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Transcription Factor | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | P19838 | CHEMBL3251 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0005488; binding | GO:0008270; zinc ion binding | 4.056E-09 | 9.812E-06 | CA1, CA12, CA2, CA3, CA5A, CA6, CA7, CA9 |
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 1.069E-27 | 2.327E-23 | CA1, CA12, CA14, CA2, CA3, CA5A, CA6, CA7, CA9 |
| BP | GO:0009987; cellular process | GO:0032849; positive regulation of cellular pH reduction | 1.061E-06 | 1.540E-03 | CA2, CA7 |
| MF | GO:0003824; catalytic activity | GO:0004064; arylesterase activity | 5.300E-06 | 6.074E-03 | CA1, CA2 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 1.507E-22 | 1.641E-18 | CA1, CA12, CA14, CA2, CA3, CA5A, CA6, CA7, CA9 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 3.105E-20 | 1.352E-16 | CA1, CA12, CA2, CA3, CA5A, CA6, CA7, CA9 |
| BP | GO:0051179; localization | GO:2001225; regulation of chloride transport | 1.588E-05 | 1.729E-02 | CA2, CA7 |
| BP | GO:0023052; signaling | GO:0032230; positive regulation of synaptic transmission, GABAergic | 2.749E-05 | 2.851E-02 | CA2, CA7 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09102 Energy metabolism | hsa00910 | Nitrogen metabolism | 3.793E-27 | 2.466E-25 | CA12, CA1, CA3, CA2, CA5A, CA7, CA6, CA9, CA14 |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 3.067E-03 | 9.683E-02 | LMNA, NFKB1 |
| 09160 Human Diseases | 09161 Cancers | hsa05220 | Chronic myeloid leukemia | 4.294E-02 | 9.683E-02 | NFKB1 |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 4.179E-02 | 9.683E-02 | CA2 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05140 | Leishmaniasis | 4.294E-02 | 9.683E-02 | NFKB1 |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 4.352E-02 | 9.683E-02 | LMNA |
| 09160 Human Diseases | 09161 Cancers | hsa05222 | Small cell lung cancer | 5.041E-02 | 9.683E-02 | NFKB1 |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 5.896E-02 | 9.683E-02 | NFKB1 |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05410 | Hypertrophic cardiomyopathy (HCM) | 4.869E-02 | 9.683E-02 | LMNA |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04931 | Insulin resistance | 6.349E-02 | 9.683E-02 | NFKB1 |
Human Diseases Associated with the Target Proteins of the Plant
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
