CMAUP Plant Collective Molecular Activities

Plant Name: Eritrichium sericeum

Plant ID: NPO27905
Plant Latin Name: Eritrichium sericeum
Taxonomy Genus: Eritrichium
Taxonomy Family: Boraginaceae

NCBI TaxonomyDB: 488675
Plant-of-the-World-Online: n.a.

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Transient receptor potential channel	TRPA1;
Enzyme_unclassified	MIF;
Lyase	CA2; CA3; CA14; CA7; CA5A; CA4; CA6; CA12; CA1; CA9; CA5B;
Nuclear hormone receptor subfamily 3 group A	ESR2;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	MIF	Macrophage migration inhibitory factor	P14174	CHEMBL2085
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA3	Carbonic anhydrase III	P07451	CHEMBL2885
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Nuclear hormone receptor subfamily 3 group A	ESR2	Estrogen receptor beta	Q92731	CHEMBL242
Transient receptor potential channel	TRPA1	Transient receptor potential cation channel subfamily A member 1	O75762	CHEMBL6007

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	2.475E-12	5.989E-09	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR2
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.707E-33	3.718E-29	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	9.527E-27	1.037E-22	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.016E-24	5.533E-21	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	1.929E-06	2.471E-03	CA2, CA7
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	9.631E-06	9.986E-03	CA1, CA2
BP	GO:0051179; localization	GO:2001225; regulation of chloride transport	2.884E-05	2.854E-02	CA2, CA7
CC	GO:0043226; organelle	GO:0097504; Gemini of coiled bodies	4.225E-05	3.833E-02	SMN1, SMN2
BP	GO:0023052; signaling	GO:0032230; positive regulation of synaptic transmission, GABAergic	4.991E-05	4.180E-02	CA2, CA7
CC	GO:0032991; macromolecular complex	GO:0032797; SMN complex	4.991E-05	4.180E-02	SMN1, SMN2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.055E-32	1.266E-31	CA12, CA1, CA3, CA5B, CA2, CA5A, CA4, CA7, CA6, CA9, CA14
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1.503E-04	9.020E-04	CA2, CA4
09120 Genetic Information Processing	09122 Translation	hsa03013	RNA transport	8.152E-03	3.261E-02	SMN2, SMN1
09100 Metabolism	09105 Amino acid metabolism	hsa00360	Phenylalanine metabolism	1.352E-02	4.056E-02	MIF
09100 Metabolism	09105 Amino acid metabolism	hsa00350	Tyrosine metabolism	2.765E-02	5.529E-02	MIF
09150 Organismal Systems	09155 Excretory system	hsa04966	Collecting duct acid secretion	2.139E-02	5.134E-02	CA2
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	5.609E-02	7.635E-02	ESR2
09150 Organismal Systems	09157 Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	7.561E-02	7.635E-02	TRPA1
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	7.635E-02	7.635E-02	ESR2
09150 Organismal Systems	09154 Digestive system	hsa04972	Pancreatic secretion	7.412E-02	7.635E-02	CA2

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	MIF;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	TRPA1;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
NA: NA	Edema	NA	CA2;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Refractory autoimmune diseases	D84.9, M35.9	MIF;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	MIF;
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
J00-J99: Diseases of the respiratory system	Throat irritation	J39.2	TRPA1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases