CMAUP Plant Collective Molecular Activities

Plant Name: Clematis flammula

Taxonomic Information:

Plant ID: NPO2786
Plant Latin Name: Clematis flammula
Taxonomy Genus: Clematis
Taxonomy Family: Ranunculaceae

Plant External Links:

NCBI TaxonomyDB: 1532743
Plant-of-the-World-Online: 709687-1

Used in Medicines:

Country/Region:

Italy; Lebanon; Spain

Traditional Medicine System:

Geographical Distribution:

Turkey; Afghanistan; Albania; Iran; Libya; Algeria; Pakistan; Tunisia; Italy; Lebanon; France; Portugal; Morocco; Greece; Hungary; New Zealand; Russia; Spain; Bulgaria

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Phosphodiesterase 4	PDE4D;
Cysteine protease	CTSV;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cysteine protease	CTSV	Cathepsin L2	O60911	CHEMBL3272
Phosphodiesterase 4	PDE4D	Phosphodiesterase 4D	Q08499	CHEMBL288

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0032502; developmental process	GO:0007568; aging	1.424E-04	9.018E-01	CTSV, PDE4D
BP	GO:0032501; multicellular organismal process	GO:1901898; negative regulation of relaxation of cardiac muscle	2.071E-04	9.018E-01	PDE4D
BP	GO:0051179; localization	GO:0032412; regulation of ion transmembrane transporter activity	2.285E-02	1.000E+00	PDE4D
BP	GO:0051179; localization	GO:0051924; regulation of calcium ion transport	2.326E-02	1.000E+00	PDE4D
CC	GO:0044464; cell part	GO:0043204; perikaryon	1.187E-02	1.000E+00	CTSV
MF	GO:0003824; catalytic activity	GO:0016787; hydrolase activity	1.835E-02	1.000E+00	CTSV, PDE4D
MF	GO:0003824; catalytic activity	GO:0004252; serine-type endopeptidase activity	2.551E-02	1.000E+00	CTSV

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09160 Human Diseases	09164 Substance dependence	hsa05032	Morphine addiction	9.080E-03	1.980E-02	PDE4D
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	1.395E-02	1.980E-02	CTSV
09140 Cellular Processes	09141 Transport and catabolism	hsa04142	Lysosome	1.226E-02	1.980E-02	CTSV
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	1.980E-02	1.980E-02	PDE4D
09100 Metabolism	09104 Nucleotide metabolism	hsa00230	Purine metabolism	1.752E-02	1.980E-02	PDE4D

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases