CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADORA3;
Peptide receptor (family A GPCR)	TSHR;
Protein Phosphatase	PTPN1;
Enzyme_unclassified	BLM;
Ionotropic glutamate receptor	GRIA4; GRIK2; GRIA1; GRIK3; GRIK5; GRIK1;
Methyl-lysine/arginine binding protein	SMN1;SMN2;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Ionotropic glutamate receptor	GRIA4	Glutamate receptor ionotropic, AMPA 4	P48058	CHEMBL3190
Ionotropic glutamate receptor	GRIK2	Glutamate receptor ionotropic kainate 2	Q13002	CHEMBL3683
Ionotropic glutamate receptor	GRIA1	Glutamate receptor ionotropic, AMPA 1	P42261	CHEMBL2009
Ionotropic glutamate receptor	GRIK3	Glutamate receptor ionotropic kainate 3	Q13003	CHEMBL3684
Ionotropic glutamate receptor	GRIK5	Glutamate receptor ionotropic kainate 5	Q16478	CHEMBL2675
Ionotropic glutamate receptor	GRIK1	Glutamate receptor ionotropic kainate 1	P39086	CHEMBL1918
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335

Showing 1 to 10 of 12 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0023052; signaling	GO:0060079; excitatory postsynaptic potential	2.798E-12	5.540E-09	GRIA1, GRIA4, GRIK1, GRIK2, GRIK3, GRIK5
BP	GO:0051179; localization	GO:0034220; ion transmembrane transport	1.130E-05	4.035E-03	GRIA1, GRIA4, GRIK1, GRIK2, GRIK3, GRIK5
BP	GO:0009987; cellular process	GO:0035235; ionotropic glutamate receptor signaling pathway	5.447E-15	3.811E-11	GRIA1, GRIA4, GRIK1, GRIK2, GRIK3, GRIK5
BP	GO:0023052; signaling	GO:0051967; negative regulation of synaptic transmission, glutamatergic	3.788E-05	1.115E-02	GRIK2, GRIK3
BP	GO:0032501; multicellular organismal process	GO:0007399; nervous system development	4.930E-05	1.394E-02	GRIK1, SMN1, SMN2, TSHR
CC	GO:0044464; cell part	GO:0043204; perikaryon	8.490E-09	1.027E-05	GRIK2, GRIK3, GRIK5, SMN1, SMN2
CC	GO:0044456; synapse part	GO:0045211; postsynaptic membrane	1.778E-07	1.335E-04	GRIA4, GRIK1, GRIK2, GRIK3, GRIK5
CC	GO:0032991; macromolecular complex	GO:0032983; kainate selective glutamate receptor complex	1.254E-06	6.561E-04	GRIK2, GRIK5
CC	GO:0044464; cell part	GO:0043005; neuron projection	6.386E-06	2.528E-03	GRIA1, GRIA4, GRIK3, GRIK5, SMN1, SMN2
CC	GO:0044456; synapse part	GO:0043195; terminal bouton	8.802E-06	3.305E-03	GRIK2, GRIK3, GRIK5

Showing 1 to 10 of 18 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09120 Genetic Information Processing	09122 Translation	hsa03013	RNA transport	5.389E-03	1.557E-02	SMN2, SMN1
09120 Genetic Information Processing	09124 Replication and repair	hsa03440	Homologous recombination	1.869E-02	4.860E-02	BLM
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1.484E-12	3.858E-11	GRIA1, GRIK5, ADORA3, GRIK3, GRIK1, GRIK2, TSHR, GRIA4
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	2.578E-04	1.950E-03	GRIA1, TSHR, GRIA4
09150 Organismal Systems	09156 Nervous system	hsa04724	Glutamatergic synapse	4.988E-11	6.484E-10	GRIA1, GRIK5, GRIK3, GRIK1, GRIK2, GRIA4
09150 Organismal Systems	09159 Environmental adaptation	hsa04713	Circadian entrainment	1.683E-03	7.055E-03	GRIA1, GRIA4
09150 Organismal Systems	09156 Nervous system	hsa04723	Retrograde endocannabinoid signaling	1.899E-03	7.055E-03	GRIA1, GRIA4
09150 Organismal Systems	09156 Nervous system	hsa04728	Dopaminergic synapse	3.074E-03	9.989E-03	GRIA1, GRIA4
09160 Human Diseases	09164 Substance dependence	hsa05033	Nicotine addiction	3.000E-04	1.950E-03	GRIA1, GRIA4
09160 Human Diseases	09164 Substance dependence	hsa05031	Amphetamine addiction	8.420E-04	4.379E-03	GRIA1, GRIA4

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ADORA3;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	ADORA3;
C00-D49: Neoplasms	Cancer	C00-C96	ADORA3;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ADORA3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	GRIK1;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	GRIK1;
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	GRIK1;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	GRIK1;
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ADORA3;

Showing 1 to 10 of 14 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Raoulia australis

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities