CMAUP Plant Collective Molecular Activities

Plant Name: Stephania hernandifolia

Taxonomic Information:

Plant ID: NPO27817
Plant Latin Name: Stephania hernandifolia
Taxonomy Genus: Stephania
Taxonomy Family: Menispermaceae

Plant External Links:

NCBI TaxonomyDB: 152366
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Thailand; India

Traditional Medicine System:

Geographical Distribution:

Thailand; India

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Protein Kinase	CDK2;
Lyase	CA14; CA7; CA5A; CA4; CA6; CA12; CA1; CA9;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Protein Kinase	CDK2	Cyclin-dependent kinase 2	P24941	CHEMBL301

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	7.628E-09	1.661E-05	CA1, CA12, CA4, CA5A, CA6, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.206E-25	2.627E-21	CA1, CA12, CA14, CA4, CA5A, CA6, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	3.318E-21	3.612E-17	CA1, CA12, CA14, CA4, CA5A, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.507E-18	6.564E-15	CA1, CA12, CA4, CA5A, CA6, CA7, CA9
CC	GO:0044464; cell part	GO:0005791; rough endoplasmic reticulum	2.215E-02	1.000E+00	CA4

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	3.449E-25	5.519E-24	CA12, CA1, CA5A, CA4, CA7, CA6, CA9, CA14
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1.030E-02	8.244E-02	CA4
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	3.935E-02	9.284E-02	CDK2
09140 Cellular Processes	09143 Cell growth and death	hsa04115	p53 signaling pathway	3.063E-02	9.284E-02	CDK2
09160 Human Diseases	09161 Cancers	hsa05222	Small cell lung cancer	3.805E-02	9.284E-02	CDK2
09150 Organismal Systems	09152 Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	4.325E-02	9.284E-02	CDK2
09140 Cellular Processes	09143 Cell growth and death	hsa04114	Oocyte meiosis	5.402E-02	9.284E-02	CDK2
09160 Human Diseases	09167 Infectious diseases	hsa05161	Hepatitis B	6.383E-02	9.284E-02	CDK2
09130 Environmental Information Processing	09132 Signal transduction	hsa04068	FoxO signaling pathway	5.829E-02	9.284E-02	CDK2
09160 Human Diseases	09167 Infectious diseases	hsa05162	Measles	5.957E-02	9.284E-02	CDK2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases