CMAUP Plant Collective Molecular Activities

Plant Name: Calotropis procera

Taxonomic Information:

Plant ID: NPO27807
Plant Latin Name: Calotropis procera
Taxonomy Genus: Calotropis
Taxonomy Family: Apocynaceae

Plant External Links:

NCBI TaxonomyDB: 141467
Plant-of-the-World-Online: 1004515-2

Used in Medicines:

Country/Region:

Israel; Algeria; Tanzania; India; Rwanda; Jordan; Kenya; Nigeria; Burkina Faso

Traditional Medicine System:

Geographical Distribution:

Brazil; Afghanistan; Bangladesh; Mauritania; Sudan; Guinea; Nepal; Costa Rica; Cambodia; Bahamas; Ethiopia; Rwanda; Trinidad and Tobago; Somalia; Pakistan; Nigeria; Bolivia; Cameroon; Cote d'Ivoire; Benin; Ghana; Israel; Australia; Iran; Algeria; Cuba; El Salvador; Thailand; Venezuela; Cape Verde; Burkina Faso; Guatemala; China; Kuwait; Jordan; Dominican Republic; Iraq; Sierra Leone; Eritrea; Netherlands; Uganda; Libya; Oman; Gambia; Tanzania; Saudi Arabia; United States; Morocco; Vietnam; Guinea-Bissau; Mali; Senegal; Yemen; Haiti; Jamaica; Honduras; Myanmar; Chad; Mexico; Egypt; India; Tunisia; Djibouti; Congo; Mozambique; Colombia; Paraguay; Kenya; Niger; Nicaragua

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Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	PLA2G1B;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	PLA2G1B	Phospholipase A2 group 1B	P04054	CHEMBL4426

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0065007; biological regulation	GO:0032431; activation of phospholipase A2 activity	2.071E-04	1.000E+00	PLA2G1B
BP	GO:0051179; localization	GO:0050482; arachidonic acid secretion	1.191E-03	1.000E+00	PLA2G1B
BP	Unclassified;	GO:0015758; glucose transport	2.381E-03	1.000E+00	PLA2G1B
BP	GO:0009987; cellular process	GO:0010524; positive regulation of calcium ion transport into cytosol	2.692E-03	1.000E+00	PLA2G1B
BP	GO:0051179; localization	GO:0008645; hexose transport	2.692E-03	1.000E+00	PLA2G1B
BP	GO:0008152; metabolic process	GO:0045740; positive regulation of DNA replication	2.847E-03	1.000E+00	PLA2G1B
BP	GO:0051179; localization	GO:0008643; carbohydrate transport	4.245E-03	1.000E+00	PLA2G1B
BP	GO:0008152; metabolic process	GO:0006633; fatty acid biosynthetic process	4.452E-03	1.000E+00	PLA2G1B
BP	Unclassified;	GO:0044236; multicellular organism metabolic process	5.488E-03	1.000E+00	PLA2G1B
BP	GO:0065007; biological regulation	GO:0051092; positive regulation of NF-kappaB transcription factor activity	7.248E-03	1.000E+00	PLA2G1B
BP	GO:0065007; biological regulation	GO:0000187; activation of MAPK activity	7.403E-03	1.000E+00	PLA2G1B
BP	Unclassified;	GO:2000021; regulation of ion homeostasis	1.077E-02	1.000E+00	PLA2G1B
BP	GO:0009987; cellular process	GO:0050714; positive regulation of protein secretion	1.217E-02	1.000E+00	PLA2G1B
BP	GO:0008152; metabolic process	GO:0016042; lipid catabolic process	1.398E-02	1.000E+00	PLA2G1B
BP	GO:0002376; immune system process	GO:0050778; positive regulation of immune response	3.743E-02	1.000E+00	PLA2G1B
CC	GO:0044464; cell part	GO:0009986; cell surface	2.806E-02	1.000E+00	PLA2G1B
MF	GO:0005488; binding	GO:0032052; bile acid binding	4.659E-04	1.000E+00	PLA2G1B

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1.250E-03	5.625E-03	PLA2G1B
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.450E-03	5.625E-03	PLA2G1B
09150 Organismal Systems	09154 Digestive system	hsa04975	Fat digestion and absorption	2.050E-03	5.625E-03	PLA2G1B
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	3.100E-03	6.200E-03	PLA2G1B
09100 Metabolism	09103 Lipid metabolism	hsa00565	Ether lipid metabolism	2.250E-03	5.625E-03	PLA2G1B
09150 Organismal Systems	09153 Circulatory system	hsa04270	Vascular smooth muscle contraction	6.000E-03	7.500E-03	PLA2G1B
09100 Metabolism	09103 Lipid metabolism	hsa00564	Glycerophospholipid metabolism	4.750E-03	6.857E-03	PLA2G1B
09150 Organismal Systems	09154 Digestive system	hsa04972	Pancreatic secretion	4.800E-03	6.857E-03	PLA2G1B
09130 Environmental Information Processing	09132 Signal transduction	hsa04014	Ras signaling pathway	1.135E-02	1.261E-02	PLA2G1B
Unclassified	Unclassified	hsa01100	Metabolic pathways	6.195E-02	6.195E-02	PLA2G1B

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases