CMAUP Plant Collective Molecular Activities

Plant Name: Calotropis procera

Taxonomic Information:

Plant ID: NPO27807
Plant Latin Name: Calotropis procera
Taxonomy Genus: Calotropis
Taxonomy Family: Apocynaceae

Plant External Links:

NCBI TaxonomyDB: 141467
Plant-of-the-World-Online: 1004515-2

Used in Medicines:

Country/Region:

Israel; Algeria; Tanzania; India; Rwanda; Jordan; Kenya; Nigeria; Burkina Faso

Traditional Medicine System:

Geographical Distribution:

Brazil; Afghanistan; Bangladesh; Mauritania; Sudan; Guinea; Nepal; Costa Rica; Cambodia; Bahamas; Ethiopia; Rwanda; Trinidad and Tobago; Somalia; Pakistan; Nigeria; Bolivia; Cameroon; Cote d'Ivoire; Benin; Ghana; Israel; Australia; Iran; Algeria; Cuba; El Salvador; Thailand; Venezuela; Cape Verde; Burkina Faso; Guatemala; China; Kuwait; Jordan; Dominican Republic; Iraq; Sierra Leone; Eritrea; Netherlands; Uganda; Libya; Oman; Gambia; Tanzania; Saudi Arabia; United States; Morocco; Vietnam; Guinea-Bissau; Mali; Senegal; Yemen; Haiti; Jamaica; Honduras; Myanmar; Chad; Mexico; Egypt; India; Tunisia; Djibouti; Congo; Mozambique; Colombia; Paraguay; Kenya; Niger; Nicaragua

Example Image

Geographical Distribution

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See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	PLA2G1B;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	PLA2G1B	Phospholipase A2 group 1B	P04054	CHEMBL4426

Showing 1 to 1 of 1 entries

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0065007; biological regulation	GO:0032431; activation of phospholipase A2 activity	2.071E-04	1.000E+00	PLA2G1B
BP	GO:0051179; localization	GO:0050482; arachidonic acid secretion	1.191E-03	1.000E+00	PLA2G1B
BP	Unclassified;	GO:0015758; glucose transport	2.381E-03	1.000E+00	PLA2G1B
BP	GO:0009987; cellular process	GO:0010524; positive regulation of calcium ion transport into cytosol	2.692E-03	1.000E+00	PLA2G1B
BP	GO:0051179; localization	GO:0008645; hexose transport	2.692E-03	1.000E+00	PLA2G1B
BP	GO:0008152; metabolic process	GO:0045740; positive regulation of DNA replication	2.847E-03	1.000E+00	PLA2G1B
BP	GO:0051179; localization	GO:0008643; carbohydrate transport	4.245E-03	1.000E+00	PLA2G1B
BP	GO:0008152; metabolic process	GO:0006633; fatty acid biosynthetic process	4.452E-03	1.000E+00	PLA2G1B
BP	Unclassified;	GO:0044236; multicellular organism metabolic process	5.488E-03	1.000E+00	PLA2G1B
BP	GO:0065007; biological regulation	GO:0051092; positive regulation of NF-kappaB transcription factor activity	7.248E-03	1.000E+00	PLA2G1B

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1.250E-03	5.625E-03	PLA2G1B
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.450E-03	5.625E-03	PLA2G1B
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	3.100E-03	6.200E-03	PLA2G1B
09100 Metabolism	09103 Lipid metabolism	hsa00565	Ether lipid metabolism	2.250E-03	5.625E-03	PLA2G1B
09100 Metabolism	09103 Lipid metabolism	hsa00564	Glycerophospholipid metabolism	4.750E-03	6.857E-03	PLA2G1B
09130 Environmental Information Processing	09132 Signal transduction	hsa04014	Ras signaling pathway	1.135E-02	1.261E-02	PLA2G1B
09150 Organismal Systems	09154 Digestive system	hsa04975	Fat digestion and absorption	2.050E-03	5.625E-03	PLA2G1B
09150 Organismal Systems	09153 Circulatory system	hsa04270	Vascular smooth muscle contraction	6.000E-03	7.500E-03	PLA2G1B
09150 Organismal Systems	09154 Digestive system	hsa04972	Pancreatic secretion	4.800E-03	6.857E-03	PLA2G1B
Unclassified	Unclassified	hsa01100	Metabolic pathways	6.195E-02	6.195E-02	PLA2G1B

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Calotropis procera

Taxonomic Information:

Plant External Links:

Used in Medicines:

Country/Region:

Traditional Medicine System:

Geographical Distribution:

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities