Plant Name: Acritopappus longifolius
Taxonomic Information:
Plant ID: NPO27794
Plant Latin Name: Acritopappus longifolius
Taxonomy Genus: Acritopappus
Taxonomy Family: Asteraceae
Plant External Links:
NCBI TaxonomyDB:
1744988
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| GPBAR1; | |
| PTPN1; PTPN2; CDC25B; | |
| PLA2G1B; AKR1B10; POLB; | |
| NR1H4; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
| Cytochrome P450 family 2 | CYP2C9 | Cytochrome P450 2C9 | P11712 | CHEMBL3397 |
| Enzyme_unclassified | PLA2G1B | Phospholipase A2 group 1B | P04054 | CHEMBL4426 |
| Enzyme_unclassified | AKR1B10 | Aldo-keto reductase family 1 member B10 | O60218 | CHEMBL5983 |
| Enzyme_unclassified | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Protein Phosphatase | PTPN1 | Protein-tyrosine phosphatase 1B | P18031 | CHEMBL335 |
| Protein Phosphatase | PTPN2 | T-cell protein-tyrosine phosphatase | P17706 | CHEMBL3807 |
| Protein Phosphatase | CDC25B | Dual specificity phosphatase Cdc25B | P30305 | CHEMBL4804 |
| Small molecule receptor (family A GPCR) | GPBAR1 | G-protein coupled bile acid receptor 1 | Q8TDU6 | CHEMBL5409 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0009987; cellular process | GO:0038183; bile acid signaling pathway | 7.235E-07 | 7.877E-03 | GPBAR1, NR1H4 |
| MF | GO:0060089; molecular transducer activity | GO:0038181; bile acid receptor activity | 7.235E-07 | 7.877E-03 | GPBAR1, NR1H4 |
| BP | GO:0009987; cellular process | GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway | 1.447E-06 | 9.897E-03 | PTPN1, PTPN2 |
| BP | GO:0050896; response to stimulus | GO:0046626; regulation of insulin receptor signaling pathway | 1.818E-06 | 9.897E-03 | NR1H4, PTPN1, PTPN2 |
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 3.614E-06 | 1.574E-02 | CYP2C19, CYP2C9 |
| BP | GO:0008152; metabolic process | GO:0008202; steroid metabolic process | 5.159E-06 | 1.605E-02 | AKR1B10, CYP2C19, CYP2C9, NR1H4 |
| MF | GO:0005488; binding | GO:0032052; bile acid binding | 8.667E-06 | 2.144E-02 | NR1H4, PLA2G1B |
| MF | GO:0003824; catalytic activity | GO:0004725; protein tyrosine phosphatase activity | 1.670E-05 | 2.469E-02 | CDC25B, PTPN1, PTPN2 |
| MF | GO:0003824; catalytic activity | GO:0008392; arachidonic acid epoxygenase activity | 3.267E-05 | 3.557E-02 | CYP2C19, CYP2C9 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 3.267E-07 | 1.013E-05 | CYP2C9, PLA2G1B, CYP2C19 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00590 | Arachidonic acid metabolism | 3.352E-06 | 5.196E-05 | CYP2C9, PLA2G1B, CYP2C19 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 5.185E-04 | 5.358E-03 | CYP2C9, CYP2C19 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 1.358E-03 | 8.421E-03 | CYP2C9, CYP2C19 |
| 09160 Human Diseases | 09161 Cancers | hsa05204 | Chemical carcinogenesis | 7.315E-04 | 5.669E-03 | CYP2C9, CYP2C19 |
| Unclassified | Unclassified | hsa01100 | Metabolic pathways | 2.276E-03 | 1.176E-02 | CYP2C9, AKR1B10, PLA2G1B, CYP2C19 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00592 | alpha-Linolenic acid metabolism | 1.243E-02 | 5.033E-02 | PLA2G1B |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00052 | Galactose metabolism | 1.490E-02 | 5.033E-02 | AKR1B10 |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00040 | Pentose and glucuronate interconversions | 1.786E-02 | 5.033E-02 | AKR1B10 |
| 09120 Genetic Information Processing | 09124 Replication and repair | hsa03410 | Base excision repair | 1.638E-02 | 5.033E-02 | POLB |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Cancer | C00-C96 | CDC25B; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
