Plant Name: Atalantia buxifolia
Taxonomic Information:
Plant ID: NPO27785
Plant Latin Name: Atalantia buxifolia
Taxonomy Genus: Atalantia
Taxonomy Family: Rutaceae
Plant External Links:
NCBI TaxonomyDB:
76974
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| DYRK1A; | |
| CTSV; | |
| ABCB1; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| ATP-binding cassette | ABCB1 | P-glycoprotein 1 | P08183 | CHEMBL4302 |
| Cysteine protease | CTSV | Cathepsin L2 | O60911 | CHEMBL3272 |
| Protein Kinase | DYRK1A | Dual-specificity tyrosine-phosphorylation regulated kinase 1A | Q13627 | CHEMBL2292 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0051179; localization | GO:1901529; positive regulation of anion channel activity | 6.212E-04 | 1.000E+00 | ABCB1 |
| BP | GO:0050896; response to stimulus | GO:0047484; regulation of response to osmotic stress | 1.397E-03 | 1.000E+00 | ABCB1 |
| BP | GO:0051179; localization | GO:2001225; regulation of chloride transport | 1.552E-03 | 1.000E+00 | ABCB1 |
| BP | GO:0051179; localization | GO:0042908; xenobiotic transport | 1.552E-03 | 1.000E+00 | ABCB1 |
| BP | GO:0008152; metabolic process | GO:0016540; protein autoprocessing | 2.173E-03 | 1.000E+00 | CTSV |
| BP | GO:0009987; cellular process | GO:0043518; negative regulation of DNA damage response, signal transduction by p53 class mediator | 2.173E-03 | 1.000E+00 | DYRK1A |
| BP | GO:0022414; reproductive process | GO:0046697; decidualization | 3.103E-03 | 1.000E+00 | CTSV |
| BP | GO:0051179; localization | GO:0006855; drug transmembrane transport | 9.908E-03 | 1.000E+00 | ABCB1 |
| BP | GO:0008152; metabolic process | GO:0018107; peptidyl-threonine phosphorylation | 1.207E-02 | 1.000E+00 | DYRK1A |
| BP | GO:0009987; cellular process | GO:0022617; extracellular matrix disassembly | 1.222E-02 | 1.000E+00 | CTSV |
| BP | GO:0009987; cellular process | GO:0000086; G2/M transition of mitotic cell cycle | 2.006E-02 | 1.000E+00 | ABCB1 |
| BP | GO:0050896; response to stimulus | GO:0009267; cellular response to starvation | 2.082E-02 | 1.000E+00 | CTSV |
| BP | GO:0048511; rhythmic process | GO:0007623; circadian rhythm | 2.098E-02 | 1.000E+00 | DYRK1A |
| BP | GO:0008152; metabolic process | GO:0018105; peptidyl-serine phosphorylation | 2.541E-02 | 1.000E+00 | DYRK1A |
| BP | GO:0008152; metabolic process | GO:0018108; peptidyl-tyrosine phosphorylation | 2.861E-02 | 1.000E+00 | DYRK1A |
| BP | GO:0008152; metabolic process | GO:0046777; protein autophosphorylation | 3.013E-02 | 1.000E+00 | DYRK1A |
| CC | GO:0044464; cell part | GO:0043204; perikaryon | 1.776E-02 | 1.000E+00 | CTSV |
| MF | GO:0005215; transporter activity | GO:0008559; xenobiotic transmembrane transporting ATPase activity | 1.087E-03 | 1.000E+00 | ABCB1 |
| MF | GO:0005488; binding | GO:0048156; tau protein binding | 1.708E-03 | 1.000E+00 | DYRK1A |
| MF | GO:0003824; catalytic activity | GO:0004712; protein serine/threonine/tyrosine kinase activity | 6.509E-03 | 1.000E+00 | DYRK1A |
| MF | GO:0003824; catalytic activity | GO:0004715; non-membrane spanning protein tyrosine kinase activity | 7.900E-03 | 1.000E+00 | DYRK1A |
| MF | GO:0005488; binding | GO:0043621; protein self-association | 8.364E-03 | 1.000E+00 | DYRK1A |
| MF | GO:0005488; binding | GO:0005524; ATP binding | 1.664E-02 | 1.000E+00 | ABCB1, DYRK1A |
| MF | GO:0003824; catalytic activity | GO:0003824; catalytic activity | 2.891E-02 | 1.000E+00 | ABCB1, CTSV, DYRK1A |
| MF | GO:0003824; catalytic activity | GO:0004252; serine-type endopeptidase activity | 3.803E-02 | 1.000E+00 | CTSV |
| MF | GO:0005488; binding | GO:0042277; peptide binding | 4.105E-02 | 1.000E+00 | CTSV |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09130 Environmental Information Processing | 09131 Membrane transport | hsa02010 | ABC transporters | 6.586E-03 | 2.607E-02 | ABCB1 |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 1.061E-02 | 2.607E-02 | ABCB1 |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 2.085E-02 | 2.607E-02 | CTSV |
| 09140 Cellular Processes | 09141 Transport and catabolism | hsa04142 | Lysosome | 1.834E-02 | 2.607E-02 | CTSV |
| 09160 Human Diseases | 09161 Cancers | hsa05206 | MicroRNAs in cancer | 4.389E-02 | 4.389E-02 | ABCB1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | ABCB1; |
| C00-D49: Neoplasms | Ovarian cancer | C56 | ABCB1; |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | ABCB1; |
| C00-D49: Neoplasms | Cancer | C00-C96 | ABCB1; |
| C00-D49: Neoplasms | Adrenocortical carcinoma | C74.0 | ABCB1; |
| A00-B99: Certain infectious and parasitic diseases | Bacterial infections | A00-B99 | ABCB1; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
