Plant ID: NPO27725
Plant Latin Name: Artemisia vestita
Taxonomy Genus: Artemisia
Taxonomy Family: Asteraceae
NCBI TaxonomyDB:
1811969
Plant-of-the-World-Online:
n.a.
Antiphlogistic; Febrifuge
India; China
BLM; GFER; POLB; APEX1; | |
GAA; | |
MAP2K1; | |
NR1H4; | |
KDM4E; | |
NPC1; |
Cytochrome P450 Enzymes: |
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Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|
Enzyme_unclassified | BLM | Bloom syndrome protein | P54132 | CHEMBL1293237 |
Enzyme_unclassified | GFER | FAD-linked sulfhydryl oxidase ALR | P55789 | CHEMBL1741189 |
Enzyme_unclassified | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
Enzyme_unclassified | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | P27695 | CHEMBL5619 |
Hydrolase | GAA | Lysosomal alpha-glucosidase | P10253 | CHEMBL2608 |
Lysine demethylase | KDM4E | Lysine-specific demethylase 4D-like | B2RXH2 | CHEMBL1293226 |
Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
Protein Kinase | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | Q02750 | CHEMBL3587 |
Unclassified | NPC1 | Niemann-Pick C1 protein | O15118 | CHEMBL1293277 |
GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|
BP | GO:0009987; cellular process | GO:0006286; base-excision repair, base-free sugar-phosphate removal | 1.930E-07 | 4.202E-03 | APEX1, POLB |
MF | GO:0005488; binding | GO:0003684; damaged DNA binding | 3.301E-06 | 1.797E-02 | APEX1, BLM, POLB |
BP | GO:0065007; biological regulation | GO:0042592; homeostatic process | 8.557E-06 | 3.727E-02 | APEX1, BLM, GAA, NPC1, NR1H4, POLB |
BP | Unclassified; | GO:2000188; regulation of cholesterol homeostasis | 1.751E-05 | 5.447E-02 | NPC1, NR1H4 |
MF | Unclassified; | GO:0003906; DNA-(apurinic or apyrimidinic site) lyase activity | 1.501E-05 | 5.447E-02 | APEX1, POLB |
BP | GO:0008152; metabolic process | GO:0006310; DNA recombination | 7.534E-05 | 1.827E-01 | APEX1, BLM, POLB |
BP | GO:0032502; developmental process | GO:0007568; aging | 1.345E-04 | 2.252E-01 | APEX1, MAP2K1, POLB |
MF | GO:0005488; binding | GO:0042162; telomeric DNA binding | 1.206E-04 | 2.252E-01 | APEX1, BLM |
MF | GO:0003824; catalytic activity | GO:0004574; oligo-1,6-glucosidase activity | 9.317E-04 | 3.689E-01 | GAA |
CC | GO:0044422; organelle part | GO:0000781; chromosome, telomeric region | 2.510E-03 | 5.256E-01 | APEX1, BLM |
CC | GO:0044464; cell part | GO:0005764; lysosome | 6.758E-03 | 7.366E-01 | GAA, NPC1 |
CC | GO:0043226; organelle | GO:0000800; lateral element | 7.432E-03 | 7.389E-01 | BLM |
CC | GO:0044464; cell part | GO:0005783; endoplasmic reticulum | 7.830E-03 | 7.607E-01 | APEX1, MAP2K1, NPC1 |
Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|---|
09120 Genetic Information Processing | 09124 Replication and repair | hsa03410 | Base excision repair | 9.436E-05 | 6.888E-03 | POLB, APEX1 |
09140 Cellular Processes | 09141 Transport and catabolism | hsa04142 | Lysosome | 1.313E-03 | 4.792E-02 | NPC1, GAA |
09120 Genetic Information Processing | 09124 Replication and repair | hsa03460 | Fanconi anemia pathway | 2.360E-02 | 8.368E-02 | BLM |
09160 Human Diseases | 09161 Cancers | hsa05210 | Colorectal cancer | 2.756E-02 | 8.368E-02 | MAP2K1 |
09160 Human Diseases | 09161 Cancers | hsa05212 | Pancreatic cancer | 2.932E-02 | 8.368E-02 | MAP2K1 |
09150 Organismal Systems | 09151 Immune system | hsa04664 | Fc epsilon RI signaling pathway | 3.019E-02 | 8.368E-02 | MAP2K1 |
09160 Human Diseases | 09161 Cancers | hsa05230 | Central carbon metabolism in cancer | 2.976E-02 | 8.368E-02 | MAP2K1 |
09160 Human Diseases | 09161 Cancers | hsa05218 | Melanoma | 3.151E-02 | 8.368E-02 | MAP2K1 |
09130 Environmental Information Processing | 09132 Signal transduction | hsa04066 | HIF-1 signaling pathway | 4.542E-02 | 8.368E-02 | MAP2K1 |
09150 Organismal Systems | 09151 Immune system | hsa04620 | Toll-like receptor signaling pathway | 4.671E-02 | 8.368E-02 | MAP2K1 |
ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
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