Plant Name: Onoseris lopezii
Taxonomic Information:
Plant ID: NPO27663
Plant Latin Name: Onoseris lopezii
Taxonomy Genus: Onoseris
Taxonomy Family: Asteraceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| NPSR1; | |
| MAPKAPK5; PRKCD; MAPKAPK2; | |
| NR1H4; | |
| GMNN; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Peptide receptor (family A GPCR) | NPSR1 | Neuropeptide S receptor | Q6W5P4 | CHEMBL5162 |
| Protein Kinase | MAPKAPK5 | MAP kinase-activated protein kinase 5 | Q8IW41 | CHEMBL3094 |
| Protein Kinase | PRKCD | Protein kinase C delta | Q05655 | CHEMBL2996 |
| Protein Kinase | MAPKAPK2 | MAP kinase-activated protein kinase 2 | P49137 | CHEMBL2208 |
| Unclassified | GMNN | Geminin | O75496 | CHEMBL1293278 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0003824; catalytic activity | GO:0009931; calcium-dependent protein serine/threonine kinase activity | 4.417E-06 | 5.770E-02 | MAPKAPK2, MAPKAPK5 |
| BP | GO:0008152; metabolic process | GO:0018105; peptidyl-serine phosphorylation | 1.201E-05 | 8.495E-02 | MAPKAPK2, MAPKAPK5, PRKCD |
| BP | GO:0009987; cellular process | GO:0090398; cellular senescence | 3.972E-05 | 8.649E-02 | MAPKAPK5, PRKCD |
| BP | GO:0065007; biological regulation | GO:0032147; activation of protein kinase activity | 8.206E-05 | 1.289E-01 | MAPKAPK2, MAPKAPK5, PRKCD |
| CC | GO:0043226; organelle | GO:0005654; nucleoplasm | 4.855E-04 | 1.788E-01 | GMNN, MAPKAPK2, MAPKAPK5, NR1H4, PRKCD |
| MF | Unclassified; | GO:0004871; signal transducer activity | 8.023E-04 | 2.142E-01 | MAPKAPK2, MAPKAPK5, NPSR1, NR1H4 |
| MF | GO:0003824; catalytic activity | GO:0004699; calcium-independent protein kinase C activity | 9.316E-04 | 2.142E-01 | PRKCD |
| CC | GO:0044464; cell part | GO:0005737; cytoplasm | 2.269E-03 | 3.555E-01 | GMNN, MAPKAPK2, MAPKAPK5, NPSR1, PRKCD |
| CC | GO:0044464; cell part | GO:0035578; azurophil granule lumen | 2.794E-02 | 1.000E+00 | PRKCD |
| CC | GO:0044464; cell part | GO:0005829; cytosol | 3.785E-02 | 1.000E+00 | GMNN, MAPKAPK2, MAPKAPK5, PRKCD |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09156 Nervous system | hsa04722 | Neurotrophin signaling pathway | 5.272E-04 | 7.907E-03 | MAPKAPK2, PRKCD |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04010 | MAPK signaling pathway | 2.348E-03 | 1.761E-02 | MAPKAPK2, MAPKAPK5 |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04930 | Type II diabetes mellitus | 1.432E-02 | 4.399E-02 | PRKCD |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04370 | VEGF signaling pathway | 1.816E-02 | 4.399E-02 | MAPKAPK2 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04912 | GnRH signaling pathway | 2.699E-02 | 4.399E-02 | PRKCD |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 2.992E-02 | 4.399E-02 | PRKCD |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 2.111E-02 | 4.399E-02 | NR1H4 |
| 09150 Organismal Systems | 09151 Immune system | hsa04666 | Fc gamma R-mediated phagocytosis | 2.758E-02 | 4.399E-02 | PRKCD |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04915 | Estrogen signaling pathway | 2.934E-02 | 4.399E-02 | PRKCD |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04931 | Insulin resistance | 3.226E-02 | 4.399E-02 | PRKCD |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| I00-I99: Diseases of the circulatory system | Neurological disease | I21, I22, R52, R52.1-R52.2, R60.9, G89 | NPSR1; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
