Plant Name: Scorzoneroides autumnalis
Taxonomic Information:
Plant ID: NPO27634
Plant Latin Name: Scorzoneroides autumnalis
Taxonomy Genus: Scorzoneroides
Taxonomy Family: Asteraceae
Plant External Links:
NCBI TaxonomyDB:
212686
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| ODC1; | |
| THRB; | |
| UGCG; | |
| AGL; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | AGL | Glycogen debranching enzyme | P35573 | CHEMBL5272 |
| Lyase | ODC1 | Ornithine decarboxylase | P11926 | CHEMBL1869 |
| Nuclear hormone receptor subfamily 1 group A | THRB | Thyroid hormone receptor beta-1 | P10828 | CHEMBL1947 |
| Transferase | UGCG | Ceramide glucosyltransferase | Q16739 | CHEMBL2063 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0050896; response to stimulus | GO:0009605; response to external stimulus | 2.870E-02 | 1.000E+00 | AGL, ODC1 |
| BP | GO:0008152; metabolic process | GO:0044262; cellular carbohydrate metabolic process | 3.030E-02 | 1.000E+00 | AGL |
| BP | GO:0008152; metabolic process | GO:0006367; transcription initiation from RNA polymerase II promoter | 3.273E-02 | 1.000E+00 | THRB |
| BP | GO:0008152; metabolic process | GO:0010565; regulation of cellular ketone metabolic process | 3.374E-02 | 1.000E+00 | ODC1 |
| BP | GO:0009987; cellular process | GO:0009755; hormone-mediated signaling pathway | 3.414E-02 | 1.000E+00 | THRB |
| BP | GO:0009987; cellular process | GO:0010822; positive regulation of mitochondrion organization | 3.454E-02 | 1.000E+00 | UGCG |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| Unclassified | Unclassified | hsa01100 | Metabolic pathways | 9.049E-04 | 6.334E-03 | UGCG, AGL, ODC1 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00600 | Sphingolipid metabolism | 9.368E-03 | 1.562E-02 | UGCG |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00500 | Starch and sucrose metabolism | 1.115E-02 | 1.562E-02 | AGL |
| 09100 Metabolism | 09105 Amino acid metabolism | hsa00330 | Arginine and proline metabolism | 9.963E-03 | 1.562E-02 | ODC1 |
| 09100 Metabolism | 09106 Metabolism of other amino acids | hsa00480 | Glutathione metabolism | 1.036E-02 | 1.562E-02 | ODC1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04919 | Thyroid hormone signaling pathway | 2.339E-02 | 2.729E-02 | THRB |
| 09130 Environmental Information Processing | 09133 Signaling molecules and interaction | hsa04080 | Neuroactive ligand-receptor interaction | 5.426E-02 | 5.426E-02 | THRB |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
