Plant Name: Idesia polycarpa
Taxonomic Information:
Plant ID: NPO27632
Plant Latin Name: Idesia polycarpa
Taxonomy Genus: Idesia
Taxonomy Family: Salicaceae
Plant External Links:
NCBI TaxonomyDB:
77057
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| HTR2B; | |
| TOP1; | |
| MTOR; | |
| CHEK1; | |
| CA2; CA1; CA7; CA12; CA9; CA14; | |
| HIF1A; TP53; | |
| PMP22; GMNN; HBB; THPO; LMNA; | |
| SMN1;SMN2; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | MTOR | Serine/threonine-protein kinase mTOR | P42345 | CHEMBL2842 |
| Isomerase | TOP1 | DNA topoisomerase I | P11387 | CHEMBL1781 |
| Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
| Lyase | CA1 | Carbonic anhydrase I | P00915 | CHEMBL261 |
| Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
| Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
| Lyase | CA14 | Carbonic anhydrase XIV | Q9ULX7 | CHEMBL3510 |
| Methyl-lysine/arginine binding protein | SMN1;SMN2 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
| Protein Kinase | CHEK1 | Serine/threonine-protein kinase Chk1 | O14757 | CHEMBL4630 |
| Small molecule receptor (family A GPCR) | HTR2B | Serotonin 2b (5-HT2b) receptor | P41595 | CHEMBL1833 |
| Transcription Factor | HIF1A | Hypoxia-inducible factor 1 alpha | Q16665 | CHEMBL4261 |
| Transcription Factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
| Unclassified | PMP22 | Peripheral myelin protein 22 | Q01453 | CHEMBL1293298 |
| Unclassified | GMNN | Geminin | O75496 | CHEMBL1293278 |
| Unclassified | HBB | Hemoglobin beta chain | P68871 | CHEMBL4331 |
| Unclassified | THPO | Thrombopoietin | P40225 | CHEMBL1293256 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 9.517E-15 | 1.036E-10 | CA1, CA12, CA14, CA2, CA7, CA9, HBB |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 1.921E-10 | 8.366E-07 | CA1, CA12, CA2, CA7, CA9 |
| BP | GO:0009987; cellular process | GO:0032849; positive regulation of cellular pH reduction | 2.748E-06 | 6.289E-03 | CA2, CA7 |
| BP | GO:0009987; cellular process | GO:0071456; cellular response to hypoxia | 2.888E-06 | 6.289E-03 | HIF1A, LMNA, MTOR, TP53 |
| BP | GO:0009987; cellular process | GO:0043618; regulation of transcription from RNA polymerase II promoter in response to stress | 3.882E-06 | 7.044E-03 | CA9, CHEK1, HIF1A, TP53 |
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 1.874E-15 | 4.081E-11 | CA1, CA12, CA14, CA2, CA7, CA9 |
Enriched KEGG Pathways of Target Proteins (Activity≤1μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09102 Energy metabolism | hsa00910 | Nitrogen metabolism | 3.757E-15 | 2.593E-13 | CA12, CA1, CA2, CA7, CA9, CA14 |
| 09160 Human Diseases | 09161 Cancers | hsa05230 | Central carbon metabolism in cancer | 3.351E-05 | 1.156E-03 | TP53, HIF1A, MTOR |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04919 | Thyroid hormone signaling pathway | 1.811E-04 | 4.165E-03 | TP53, HIF1A, MTOR |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| I00-I99: Diseases of the circulatory system | Edema associated with congestive heart failure | I50, R60.9 | CA2; |
| C00-D49: Neoplasms | Breast cancer | C50 | TOP1; CA9; |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | TP53; |
| C00-D49: Neoplasms | Sarcoma | C81-C86 | MTOR; |
| A00-B99: Certain infectious and parasitic diseases | Dutch elm disease | B81-B83 | MTOR; |
| NA: NA | Edema | NA | CA2; |
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | TP53; |
| C00-D49: Neoplasms | Renal cancer | C64 | MTOR; CA9; |
| I00-I99: Diseases of the circulatory system | Restenosis | I51.89 | MTOR; |
| C00-D49: Neoplasms | Clear cell renal cell carcinoma | C64 | CA9; |
| I00-I99: Diseases of the circulatory system | High blood pressure | I10-I16 | CA2; |
| C00-D49: Neoplasms | Lung cancer | C33-C34 | TOP1; |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | CHEK1; HIF1A; MTOR; CA9; |
| I00-I99: Diseases of the circulatory system | Cerebral infarction | I63 | HTR2B; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Psychoses | F20-F29 | HTR2B; |
| I00-I99: Diseases of the circulatory system | Pulmonary arterial hypertension | I27.0, I27.2 | HIF1A; HTR2B; |
| C00-D49: Neoplasms | Advanced ovarian cancer | NA | TOP1; |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Toxicity | T36-T50, T51-T65 | TP53; |
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Transplant rejection | D89.8, T86 | MTOR; |
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Beta thalassemia | D56.1 | HBB; |
| H00-H59: Diseases of the eye and adnexa | Chronic glaucoma | H40-H42 | CA1; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Insomnia | F51.0, G47.0 | CA2; |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | MTOR; |
| K00-K95: Diseases of the digestive system | Ulcerative colitis | K51 | MTOR; |
| A00-B99: Certain infectious and parasitic diseases | Acquired immune deficiency syndrome | B20 | TOP1; |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | TP53; |
| K00-K95: Diseases of the digestive system | Duodenal ulcers | K25-K27 | CA2; CA1; |
| I00-I99: Diseases of the circulatory system | Congestive heart failure | I50 | HTR2B; |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | TOP1; TP53; |
| C00-D49: Neoplasms | Advanced solid tumor | C00-C75, C7A, C7B | CHEK1; |
| I00-I99: Diseases of the circulatory system | Coronary heart disease | I25.1 | HTR2B; |
| NA: NA | Coronary artery restenosis | NA | MTOR; |
| C00-D49: Neoplasms | Late-stage solid tumors | C00-C75, C7A, C7B, D10-D36, D3A | TOP1; TP53; |
| C00-D49: Neoplasms | Advanced kidney cancer | C64 | MTOR; |
| C00-D49: Neoplasms | Gastric cancer | C16 | TOP1; |
| G00-G99: Diseases of the nervous system G00-G99 | Spinal muscular atrophy | G00-G99 | SMN1;SMN2; |
| H60-H95: Diseases of the ear and mastoid process | Hearing disorder | H90.5 | TP53; |
| C00-D49: Neoplasms | Metastatic colorectal cancer | C18-C21 | TOP1; |
| G00-G99: Diseases of the nervous system G00-G99 | Migraine | G43 | HTR2B; |
| C00-D49: Neoplasms | Ovarian cancer | C56 | TOP1; |
| I00-I99: Diseases of the circulatory system | Renal artery disease | I70.1 | TP53; |
| C00-D49: Neoplasms | Metastatic breast cancer | C50 | TOP1; |
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | MTOR; |
| C00-D49: Neoplasms | Pancreatic cancer | C25 | CHEK1; MTOR; |
| C00-D49: Neoplasms | Multiple myeloma | C90 | MTOR; |
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Organ rejection | D89.8, T86 | MTOR; |
| C00-D49: Neoplasms | Oral cavity cancer | C00-C08 | TP53; |
| C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | CHEK1; MTOR; |
| C00-D49: Neoplasms | Non-hodgkin's lymphoma | C85 | MTOR; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Depression | F30-F39 | HTR2B; |
| A00-B99: Certain infectious and parasitic diseases | Human immunodeficiency virus infection | B20-B26 | TOP1; |
| C00-D49: Neoplasms | Myelodysplastic syndrome | D46 | TOP1; |
| H00-H59: Diseases of the eye and adnexa | Open-angle glaucoma | H40-H42 | CA2; |
| C00-D49: Neoplasms | Cancer | C00-C96 | TOP1; CHEK1; HIF1A; TP53; MTOR; CA1; CA9; |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | TOP1; CHEK1; HIF1A; TP53; MTOR; CA9; |
| C00-D49: Neoplasms | Bladder cancer | C67 | TOP1; MTOR; |
| A00-B99: Certain infectious and parasitic diseases | Irritable bowel syndrome | A09, K58, K59.1 | HTR2B; |
| C00-D49: Neoplasms | Solid tumors | NA | MTOR; |
| H00-H59: Diseases of the eye and adnexa | Glaucoma | H40-H42 | CA1; |
| C00-D49: Neoplasms | Glioblastoma multiforme | C71 | TOP1; |
| C00-D49: Neoplasms | Esophageal cancer | C15 | TOP1; |
>> Profiles of ingredients and activity landscape
>> Collective molecular activities profile at 10μM cutoff
>> Targets derived from weak experimental activities
