CMAUP Plant Collective Molecular Activities

Plant Name: Citrus japonica

Taxonomic Information:

Plant ID: NPO27623
Plant Latin Name: Citrus japonica
Taxonomy Genus: Citrus
Taxonomy Family: Rutaceae

Plant External Links:

NCBI TaxonomyDB: 76966
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

India

Traditional Medicine System:

Indian Folk

Geographical Distribution:

India

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	EIF4A1; ALDH1A1; UBE2N;
Lyase	CA4; CA6;
Nuclear hormone receptor subfamily 1 group A	THRB;
Transcription Factor	RELA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP19A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Enzyme_unclassified	EIF4A1	Eukaryotic initiation factor 4A-I	P60842	CHEMBL2052028
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Enzyme_unclassified	UBE2N	Ubiquitin-conjugating enzyme E2 N	P61088	CHEMBL6089
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Nuclear hormone receptor subfamily 1 group A	THRB	Thyroid hormone receptor beta-1	P10828	CHEMBL1947
Transcription Factor	RELA	Nuclear factor NF-kappa-B p65 subunit	Q04206	CHEMBL5533

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	9.390E-05	3.408E-01	CA4, CA6
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.572E-05	3.408E-01	CA4, CA6
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.408E-04	4.364E-01	CA4, CA6
CC	GO:0044421; extracellular region part	GO:0070062; extracellular exosome	2.026E-04	4.364E-01	ALDH1A1, CA4, CA6, EIF4A1, THRB, UBE2N
MF	GO:0005488; binding	GO:0046914; transition metal ion binding	5.495E-04	7.039E-01	CA4, CA6, CYP19A1, THRB
MF	GO:0005488; binding	GO:0005497; androgen binding	1.656E-03	9.012E-01	ALDH1A1
CC	GO:0032991; macromolecular complex	GO:0033256; I-kappaB/NF-kappaB complex	2.896E-03	9.702E-01	RELA

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.898E-05	1.158E-03	CA4, CA6
09160 Human Diseases	09167 Infectious diseases	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	2.688E-02	7.547E-02	RELA
09150 Organismal Systems	09151 Immune system	hsa04623	Cytosolic DNA-sensing pathway	2.532E-02	7.547E-02	RELA
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	2.844E-02	7.547E-02	RELA
09150 Organismal Systems	09151 Immune system	hsa04662	B cell receptor signaling pathway	2.883E-02	7.547E-02	RELA
09160 Human Diseases	09167 Infectious diseases	hsa05131	Shigellosis	2.571E-02	7.547E-02	RELA
09150 Organismal Systems	09152 Endocrine system	hsa04920	Adipocytokine signaling pathway	2.766E-02	7.547E-02	RELA
09160 Human Diseases	09161 Cancers	hsa05220	Chronic myeloid leukemia	2.883E-02	7.547E-02	RELA
09160 Human Diseases	09167 Infectious diseases	hsa05140	Leishmaniasis	2.883E-02	7.547E-02	RELA
09150 Organismal Systems	09151 Immune system	hsa04622	RIG-I-like receptor signaling pathway	2.766E-02	7.547E-02	RELA

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperthyroidism	E05	THRB;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	THRB;
E00-E89: Endocrine, nutritional and metabolic diseases	High cholesterol levels in blood	E78.0	THRB;
E00-E89: Endocrine, nutritional and metabolic diseases	Lipid metabolism disorder	E75-E78	THRB;
S00-T88: Injury, poisoning and certain other consequences of external causes	Wound healing	T14.0-T14.1	THRB;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypothyroidism	E03	THRB;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases