CMAUP Plant Collective Molecular Activities

Plant Name: Phoenix dactylifera

Taxonomic Information:

Plant ID: NPO27617
Plant Latin Name: Phoenix dactylifera
Taxonomy Genus: Phoenix
Taxonomy Family: Arecaceae

Plant External Links:

NCBI TaxonomyDB: 42345
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Iraq; India

Traditional Medicine System:

Geographical Distribution:

Iraq; India

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Lyase	CA2; CA1; CA12; CA9;
Nuclear hormone receptor subfamily 3 group C	AR;
Enzyme_unclassified	HPGD; TNKS; PARP1; TNKS2;
Transcription Factor	TP53;
Unclassified	RAB9A; NPC1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP19A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Enzyme_unclassified	TNKS	Tankyrase-1	O95271	CHEMBL6164
Enzyme_unclassified	PARP1	Poly [ADP-ribose] polymerase-1	P09874	CHEMBL3105
Enzyme_unclassified	TNKS2	Tankyrase-2	Q9H2K2	CHEMBL6154
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Nuclear hormone receptor subfamily 3 group C	AR	Androgen Receptor	P10275	CHEMBL1871
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.676E-10	3.650E-06	CA1, CA12, CA2, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	7.177E-09	5.209E-05	CA1, CA12, CA2, CA9
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.015E-08	5.528E-05	AR, CA1, CA12, CA2, CA9, PARP1, TNKS, TP53
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.649E-08	7.182E-05	CA1, CA12, CA2, CA9
MF	GO:0003824; catalytic activity	GO:0003950; NAD+ ADP-ribosyltransferase activity	6.137E-07	1.215E-03	PARP1, TNKS, TNKS2
BP	GO:0065007; biological regulation	GO:1904357; negative regulation of telomere maintenance via telomere lengthening	6.901E-07	1.252E-03	PARP1, TNKS, TNKS2
BP	GO:0008152; metabolic process	GO:0070213; protein auto-ADP-ribosylation	2.507E-06	3.211E-03	TNKS, TNKS2
BP	GO:0008152; metabolic process	GO:0070212; protein poly-ADP-ribosylation	6.262E-06	6.494E-03	PARP1, TNKS
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	6.262E-06	6.494E-03	CA1, CA2
BP	GO:0050896; response to stimulus	GO:0048545; response to steroid hormone	1.061E-05	8.885E-03	AR, CA2, NPC1, PARP1
CC	GO:0043226; organelle	GO:0000242; pericentriolar material	7.890E-05	3.506E-02	TNKS, TNKS2
CC	GO:0043226; organelle	GO:0000784; nuclear chromosome, telomeric region	8.296E-05	3.613E-02	PARP1, TNKS, TNKS2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	2.541E-10	1.245E-08	CA12, CA1, CA2, CA9
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	1.479E-03	3.624E-02	AR, TP53
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	3.608E-03	4.419E-02	PARP1, TP53
09160 Human Diseases	09167 Infectious diseases	hsa05162	Measles	3.409E-03	4.419E-02	RAB9A, TP53
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	5.886E-03	5.769E-02	HPGD, TP53
09160 Human Diseases	09161 Cancers	hsa05213	Endometrial cancer	3.329E-02	8.869E-02	TP53
09150 Organismal Systems	09154 Digestive system	hsa04971	Gastric acid secretion	4.706E-02	8.869E-02	CA2
09160 Human Diseases	09161 Cancers	hsa05220	Chronic myeloid leukemia	4.644E-02	8.869E-02	TP53
09140 Cellular Processes	09143 Cell growth and death	hsa04115	p53 signaling pathway	4.395E-02	8.869E-02	TP53
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	4.519E-02	8.869E-02	CA2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Cancer	C00-C96	TP53;
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	TP53;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53;
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53;
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53;
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53;
C00-D49: Neoplasms	Solid tumours	C00-D48	TP53;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases