Plant Name: Berberis lambertii
Taxonomic Information:
Plant ID: NPO27616
Plant Latin Name: Berberis lambertii
Taxonomy Genus: Berberis
Taxonomy Family: Berberidaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| PTPN11; | |
| TERT; | |
| NR1H4; | |
| HSF1; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | TERT | Telomerase reverse transcriptase | O14746 | CHEMBL2916 |
| Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Protein Phosphatase | PTPN11 | Protein-tyrosine phosphatase 2C | Q06124 | CHEMBL3864 |
| Unclassified | HSF1 | Heat shock factor protein 1 | Q00613 | CHEMBL5869 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0009987; cellular process | GO:0045931; positive regulation of mitotic cell cycle | 1.614E-06 | 7.030E-03 | HSF1, PTPN11, TERT |
| BP | GO:0050896; response to stimulus | GO:2001275; positive regulation of glucose import in response to insulin stimulus | 3.374E-06 | 1.225E-02 | NR1H4, PTPN11 |
| MF | GO:0005488; binding | GO:0051427; hormone receptor binding | 4.675E-04 | 1.083E-01 | NR1H4, PTPN11 |
| CC | GO:0043226; organelle | GO:0005654; nucleoplasm | 5.957E-04 | 1.137E-01 | HSF1, NR1H4, PTPN11, TERT |
| MF | GO:0005488; binding | GO:0043565; sequence-specific DNA binding | 6.147E-04 | 1.137E-01 | HSF1, NR1H4, TERT |
| MF | GO:0060089; molecular transducer activity | GO:0038181; bile acid receptor activity | 6.212E-04 | 1.137E-01 | NR1H4 |
| MF | GO:0005488; binding | GO:0097677; STAT family protein binding | 1.242E-03 | 1.610E-01 | HSF1 |
| MF | GO:0060089; molecular transducer activity | GO:0004887; thyroid hormone receptor activity | 1.449E-03 | 1.744E-01 | NR1H4 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09160 Human Diseases | 09167 Infectious diseases | hsa05134 | Legionellosis | 1.096E-02 | 3.872E-02 | HSF1 |
| 09160 Human Diseases | 09161 Cancers | hsa05211 | Renal cell carcinoma | 1.314E-02 | 3.872E-02 | PTPN11 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection | 1.353E-02 | 3.872E-02 | PTPN11 |
| 09160 Human Diseases | 09161 Cancers | hsa05220 | Chronic myeloid leukemia | 1.452E-02 | 3.872E-02 | PTPN11 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04920 | Adipocytokine signaling pathway | 1.393E-02 | 3.872E-02 | PTPN11 |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 1.413E-02 | 3.872E-02 | NR1H4 |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04931 | Insulin resistance | 2.162E-02 | 4.144E-02 | PTPN11 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04722 | Neurotrophin signaling pathway | 2.379E-02 | 4.144E-02 | PTPN11 |
| 09150 Organismal Systems | 09151 Immune system | hsa04650 | Natural killer cell mediated cytotoxicity | 2.673E-02 | 4.144E-02 | PTPN11 |
| 09150 Organismal Systems | 09151 Immune system | hsa04670 | Leukocyte transendothelial migration | 2.339E-02 | 4.144E-02 | PTPN11 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Pancreatic cancer | C25 | TERT; |
| C00-D49: Neoplasms | Tumors | C00-D48 | TERT; |
| C00-D49: Neoplasms | Prostate cancer | C61 | TERT; |
| C00-D49: Neoplasms | Breast cancer | C50 | TERT; |
| C00-D49: Neoplasms | Brain cancer | C71, D33 | TERT; |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | TERT; |
| C00-D49: Neoplasms | Multiple myeloma | C90 | TERT; |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | TERT; |
| C00-D49: Neoplasms | Melanoma | C43 | TERT; |
| H00-H59: Diseases of the eye and adnexa | Ocular inflammation | H16.229 | TERT; |
| C00-D49: Neoplasms | Liver cancer | C22 | TERT; |
| C00-D49: Neoplasms | Ovarian cancer | C56 | TERT; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
