CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Protein Phosphatase	PTPN11;
Enzyme_unclassified	TERT;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Unclassified	HSF1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	TERT	Telomerase reverse transcriptase	O14746	CHEMBL2916
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Protein Phosphatase	PTPN11	Protein-tyrosine phosphatase 2C	Q06124	CHEMBL3864
Unclassified	HSF1	Heat shock factor protein 1	Q00613	CHEMBL5869

Showing 1 to 4 of 4 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0045931; positive regulation of mitotic cell cycle	1.614E-06	7.030E-03	HSF1, PTPN11, TERT
BP	GO:0050896; response to stimulus	GO:2001275; positive regulation of glucose import in response to insulin stimulus	3.374E-06	1.225E-02	NR1H4, PTPN11
CC	GO:0043226; organelle	GO:0005654; nucleoplasm	5.957E-04	1.137E-01	HSF1, NR1H4, PTPN11, TERT
MF	GO:0005488; binding	GO:0051427; hormone receptor binding	4.675E-04	1.083E-01	NR1H4, PTPN11
MF	GO:0005488; binding	GO:0043565; sequence-specific DNA binding	6.147E-04	1.137E-01	HSF1, NR1H4, TERT
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	6.212E-04	1.137E-01	NR1H4
MF	GO:0005488; binding	GO:0097677; STAT family protein binding	1.242E-03	1.610E-01	HSF1
MF	GO:0060089; molecular transducer activity	GO:0004887; thyroid hormone receptor activity	1.449E-03	1.744E-01	NR1H4

Showing 1 to 8 of 8 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09152 Endocrine system	hsa04920	Adipocytokine signaling pathway	1.393E-02	3.872E-02	PTPN11
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	1.413E-02	3.872E-02	NR1H4
09150 Organismal Systems	09156 Nervous system	hsa04722	Neurotrophin signaling pathway	2.379E-02	4.144E-02	PTPN11
09150 Organismal Systems	09151 Immune system	hsa04650	Natural killer cell mediated cytotoxicity	2.673E-02	4.144E-02	PTPN11
09150 Organismal Systems	09151 Immune system	hsa04670	Leukocyte transendothelial migration	2.339E-02	4.144E-02	PTPN11
09160 Human Diseases	09167 Infectious diseases	hsa05134	Legionellosis	1.096E-02	3.872E-02	HSF1
09160 Human Diseases	09161 Cancers	hsa05211	Renal cell carcinoma	1.314E-02	3.872E-02	PTPN11
09160 Human Diseases	09167 Infectious diseases	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	1.353E-02	3.872E-02	PTPN11
09160 Human Diseases	09161 Cancers	hsa05220	Chronic myeloid leukemia	1.452E-02	3.872E-02	PTPN11
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	2.162E-02	4.144E-02	PTPN11

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Pancreatic cancer	C25	TERT;
C00-D49: Neoplasms	Tumors	C00-D48	TERT;
C00-D49: Neoplasms	Prostate cancer	C61	TERT;
C00-D49: Neoplasms	Breast cancer	C50	TERT;
C00-D49: Neoplasms	Brain cancer	C71, D33	TERT;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TERT;
C00-D49: Neoplasms	Multiple myeloma	C90	TERT;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TERT;
C00-D49: Neoplasms	Melanoma	C43	TERT;
C00-D49: Neoplasms	Liver cancer	C22	TERT;

Showing 1 to 10 of 12 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Berberis lambertii

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities