Plant ID: NPO2761
Plant Latin Name: Cynanchum stauntoni
Taxonomy Genus: Cynanchum
Taxonomy Family: Apocynaceae
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
MAPK1; | |
CA2; | |
SMN1;SMN2; | |
POLB; |
Cytochrome P450 Enzymes: | CYP3A4; |
---|
Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|
Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
Enzyme_unclassified | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
Methyl-lysine/arginine binding protein | SMN1;SMN2 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
Protein Kinase | MAPK1 | MAP kinase ERK2 | P28482 | CHEMBL4040 |
GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|
BP | GO:0032502; developmental process | GO:0009887; animal organ morphogenesis | 1.181E-04 | 4.697E-01 | CA2, MAPK1, POLB |
BP | GO:0050896; response to stimulus | GO:0043627; response to estrogen | 1.398E-04 | 4.697E-01 | CA2, MAPK1 |
BP | GO:0065007; biological regulation | GO:0030641; regulation of cellular pH | 2.371E-04 | 4.697E-01 | CA2, MAPK1 |
BP | GO:0023052; signaling | GO:0050806; positive regulation of synaptic transmission | 3.844E-04 | 4.697E-01 | CA2, MAPK1 |
BP | GO:0009987; cellular process | GO:0006286; base-excision repair, base-free sugar-phosphate removal | 5.177E-04 | 4.697E-01 | POLB |
MF | GO:0003824; catalytic activity | GO:0070576; vitamin D 24-hydroxylase activity | 7.764E-04 | 4.830E-01 | CYP3A4 |
CC | GO:0044464; cell part | GO:0030424; axon | 1.717E-03 | 6.561E-01 | CA2, MAPK1 |
CC | Unclassified; | GO:0031143; pseudopodium | 4.393E-03 | 8.940E-01 | MAPK1 |
CC | GO:0043226; organelle | GO:0005876; spindle microtubule | 1.365E-02 | 1.000E+00 | POLB |
CC | GO:0044464; cell part | GO:0032838; plasma membrane bounded cell projection cytoplasm | 1.723E-02 | 1.000E+00 | MAPK1 |
CC | GO:0016020; membrane | GO:0005901; caveola | 1.825E-02 | 1.000E+00 | MAPK1 |
Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|---|
09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 1.234E-04 | 1.259E-02 | CA2, CYP3A4 |
09160 Human Diseases | 09161 Cancers | hsa05203 | Viral carcinogenesis | 1.024E-03 | 4.303E-02 | POLB, MAPK1 |
09150 Organismal Systems | 09155 Excretory system | hsa04966 | Collecting duct acid secretion | 6.732E-03 | 4.303E-02 | CA2 |
09150 Organismal Systems | 09156 Nervous system | hsa04724 | Glutamatergic synapse | 2.818E-02 | 4.303E-02 | MAPK1 |
09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 2.769E-02 | 4.303E-02 | MAPK1 |
09160 Human Diseases | 09167 Infectious diseases | hsa05145 | Toxoplasmosis | 2.916E-02 | 4.303E-02 | MAPK1 |
09150 Organismal Systems | 09151 Immune system | hsa04611 | Platelet activation | 3.013E-02 | 4.303E-02 | MAPK1 |
09130 Environmental Information Processing | 09132 Signal transduction | hsa04071 | Sphingolipid signaling pathway | 2.965E-02 | 4.303E-02 | MAPK1 |
09140 Cellular Processes | 09143 Cell growth and death | hsa04114 | Oocyte meiosis | 3.038E-02 | 4.303E-02 | MAPK1 |
09150 Organismal Systems | 09153 Circulatory system | hsa04270 | Vascular smooth muscle contraction | 2.965E-02 | 4.303E-02 | MAPK1 |
ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
---|---|---|---|
I00-I99: Diseases of the circulatory system | Edema associated with congestive heart failure | I50, R60.9 | CA2; |
NA: NA | Edema | NA | CA2; |
K00-K95: Diseases of the digestive system | Duodenal ulcers | K25-K27 | CA2; |
H00-H59: Diseases of the eye and adnexa | Open-angle glaucoma | H40-H42 | CA2; |
G00-G99: Diseases of the nervous system G00-G99 | Spinal muscular atrophy | G00-G99 | SMN1;SMN2; |
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Insomnia | F51.0, G47.0 | CA2; |
I00-I99: Diseases of the circulatory system | High blood pressure | I10-I16 | CA2; |