CMAUP Plant Collective Molecular Activities

Plant Name: Viola odorata

Taxonomic Information:

Plant ID: NPO27594
Plant Latin Name: Viola odorata
Taxonomy Genus: Viola
Taxonomy Family: Violaceae

Plant External Links:

NCBI TaxonomyDB: 97441
Plant-of-the-World-Online: 868828-1

Used in Medicines:

Country/Region:

Israel; Albania; Italy; India; Indonesia; Lebanon; Jordan; Chile; Argentina

Traditional Medicine System:

Unani; Indian Folk; Homeopathy; Ayurveda

Medicinal Functions:

Antiinflammatory; Antirheumatic; Cancer; Demulcent; Diaphoretic; Diuretic; Emetic; Emollient; Expectorant; Homeopathy; Laxative; Purgative

Geographical Distribution:

Turkey; Italy; Peru; Lebanon; France; Ireland; Argentina; Norway; Israel; Belarus; Algeria; Cuba; Venezuela; Russia; Trinidad and Tobago; Jordan; Chile; Belgium; Germany; Haiti; Spain; Ukraine; Netherlands; Denmark; Poland; Indonesia; United States; Morocco; Sweden; Switzerland; Dominican Republic; Bulgaria; Romania; Albania; Portugal; Mexico; Tunisia; India; United Kingdom; Austria; Greece; Hungary

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	GPBAR1;
Protein Phosphatase	PTPN1; PTPN2; CDC25B;
Enzyme_unclassified	PLA2G1B; AKR1B10; POLB;
Nuclear hormone receptor subfamily 1 group H	NR1H4;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C19; CYP2C9;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Enzyme_unclassified	PLA2G1B	Phospholipase A2 group 1B	P04054	CHEMBL4426
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335
Protein Phosphatase	PTPN2	T-cell protein-tyrosine phosphatase	P17706	CHEMBL3807
Protein Phosphatase	CDC25B	Dual specificity phosphatase Cdc25B	P30305	CHEMBL4804
Small molecule receptor (family A GPCR)	GPBAR1	G-protein coupled bile acid receptor 1	Q8TDU6	CHEMBL5409

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	7.235E-07	7.877E-03	GPBAR1, NR1H4
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	7.235E-07	7.877E-03	GPBAR1, NR1H4
BP	GO:0009987; cellular process	GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway	1.447E-06	9.897E-03	PTPN1, PTPN2
BP	GO:0050896; response to stimulus	GO:0046626; regulation of insulin receptor signaling pathway	1.818E-06	9.897E-03	NR1H4, PTPN1, PTPN2
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	3.614E-06	1.574E-02	CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	5.159E-06	1.605E-02	AKR1B10, CYP2C19, CYP2C9, NR1H4
MF	GO:0005488; binding	GO:0032052; bile acid binding	8.667E-06	2.144E-02	NR1H4, PLA2G1B
MF	GO:0003824; catalytic activity	GO:0004725; protein tyrosine phosphatase activity	1.670E-05	2.469E-02	CDC25B, PTPN1, PTPN2
MF	GO:0003824; catalytic activity	GO:0008392; arachidonic acid epoxygenase activity	3.267E-05	3.557E-02	CYP2C19, CYP2C9

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	3.267E-07	1.013E-05	CYP2C9, PLA2G1B, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	3.352E-06	5.196E-05	CYP2C9, PLA2G1B, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5.185E-04	5.358E-03	CYP2C9, CYP2C19
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	1.358E-03	8.421E-03	CYP2C9, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	7.315E-04	5.669E-03	CYP2C9, CYP2C19
Unclassified	Unclassified	hsa01100	Metabolic pathways	2.276E-03	1.176E-02	CYP2C9, AKR1B10, PLA2G1B, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1.243E-02	5.033E-02	PLA2G1B
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	1.490E-02	5.033E-02	AKR1B10
09100 Metabolism	09101 Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1.786E-02	5.033E-02	AKR1B10
09100 Metabolism	09101 Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1.589E-02	5.033E-02	AKR1B10

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Cancer	C00-C96	CDC25B;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases