CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	GPER1;
Enzyme_unclassified	BLM; AOX1;
Nuclear hormone receptor subfamily 3 group C	AR;
Nuclear hormone receptor subfamily 3 group A	ESR2; ESR1;
Nuclear hormone receptor subfamily 3 group B	ESRRB; ESRRA;
Unclassified	SHBG; MAPT;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	AOX1	Aldehyde oxidase	Q06278	CHEMBL3257
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Nuclear hormone receptor subfamily 3 group A	ESR2	Estrogen receptor beta	Q92731	CHEMBL242
Nuclear hormone receptor subfamily 3 group A	ESR1	Estrogen receptor alpha	P03372	CHEMBL206
Nuclear hormone receptor subfamily 3 group B	ESRRB	Estrogen-related receptor beta	O95718	CHEMBL3751
Nuclear hormone receptor subfamily 3 group B	ESRRA	Estrogen-related receptor alpha	P11474	CHEMBL3429
Nuclear hormone receptor subfamily 3 group C	AR	Androgen Receptor	P10275	CHEMBL1871
Small molecule receptor (family A GPCR)	GPER1	G-protein coupled estrogen receptor 1	Q99527	CHEMBL5872

Showing 1 to 10 of 12 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0006367; transcription initiation from RNA polymerase II promoter	4.468E-08	9.729E-05	AR, ESR1, ESR2, ESRRA, ESRRB
MF	GO:0060089; molecular transducer activity	GO:0038052; RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding	4.181E-07	6.070E-04	ESR1, ESR2
MF	GO:0005488; binding	GO:0034056; estrogen response element binding	2.507E-06	3.033E-03	ESR1, ESR2
MF	GO:0005488; binding	GO:0005497; androgen binding	2.507E-06	3.033E-03	AR, SHBG
MF	GO:0005488; binding	GO:0008270; zinc ion binding	7.265E-06	7.190E-03	AR, BLM, ESR1, ESR2, ESRRA, ESRRB
MF	GO:0005488; binding	GO:0005496; steroid binding	1.397E-16	3.043E-12	AR, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, GPER1, SHBG

Showing 1 to 6 of 6 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	7.927E-04	7.044E-03	AOX1, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	8.928E-04	7.044E-03	AOX1, CYP3A4
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	3.246E-05	9.413E-04	GPER1, ESR1, ESR2
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	9.716E-04	7.044E-03	ESR1, ESR2

Showing 1 to 4 of 4 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Trematode infection	B66.9	ESR1;
C00-D49: Neoplasms	Bladder cancer	C67	AR;
C00-D49: Neoplasms	Breast cancer	C50	ESR1; AR;
C00-D49: Neoplasms	Adrenocortical carcinoma	C74.0	ESR1;
C00-D49: Neoplasms	Brain cancer	C71, D33	ESR1;
C00-D49: Neoplasms	Prostate cancer	C61	ESR1; AR;
C00-D49: Neoplasms	Metastatic prostate cancer	C61	AR;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	AR;
C00-D49: Neoplasms	Hormone refractory prostate cancer	C61	ESR1; AR;
C00-D49: Neoplasms	Cancer	C00-C96	ESR1; AR;

Showing 1 to 10 of 77 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Iryanthera lancifolia

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities