CMAUP Plant Collective Molecular Activities

Plant Name: Casuarina equisetifolia

Taxonomic Information:

Plant ID: NPO27520
Plant Latin Name: Casuarina equisetifolia
Taxonomy Genus: Casuarina
Taxonomy Family: Casuarinaceae

Plant External Links:

NCBI TaxonomyDB: 3523
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Australia; Philippines; Indonesia; India; Malaysia; Thailand

Traditional Medicine System:

Geographical Distribution:

Australia; Philippines; Indonesia; India; Malaysia; Thailand

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	TDP1; GFER;
Transferase	FUT7;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	GFER	FAD-linked sulfhydryl oxidase ALR	P55789	CHEMBL1741189
Transferase	FUT7	Alpha-(1,3)-fucosyltransferase 7	Q11130	CHEMBL3596077

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0032501; multicellular organismal process	GO:0001889; liver development	1.622E-02	1.000E+00	GFER
BP	GO:0009987; cellular process	GO:0006302; double-strand break repair	2.633E-02	1.000E+00	TDP1
BP	GO:0008152; metabolic process	GO:0006486; protein glycosylation	4.271E-02	1.000E+00	FUT7
MF	GO:0005488; binding	GO:0050660; flavin adenine dinucleotide binding	1.145E-02	1.000E+00	GFER
MF	GO:0003824; catalytic activity	GO:0003824; catalytic activity	2.891E-02	1.000E+00	FUT7, GFER, TDP1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09107 Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	3.895E-03	6.965E-03	FUT7
09100 Metabolism	09107 Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	4.643E-03	6.965E-03	FUT7
Unclassified	Unclassified	hsa01100	Metabolic pathways	1.746E-01	1.746E-01	FUT7

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases