CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	FFAR1; FFAR4;
Enzyme_unclassified	ALOX15;
Oxidoreductase	PTGS1;
Unclassified	FABP3; PAX8; FABP4; LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP1A1;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Oxidoreductase	PTGS1	Cyclooxygenase-1	P23219	CHEMBL221
Small molecule receptor (family A GPCR)	FFAR1	Free fatty acid receptor 1	O14842	CHEMBL4422
Small molecule receptor (family A GPCR)	FFAR4	G-protein coupled receptor 120	Q5NUL3	CHEMBL5339
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	PAX8	Paired box protein Pax-8	Q06710	CHEMBL2362980
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0065007; biological regulation	GO:0010817; regulation of hormone levels	2.814E-06	4.086E-03	CYP1A1, CYP1B1, FFAR1, FFAR4, PAX8
MF	GO:0005488; binding	GO:0005504; fatty acid binding	2.904E-07	9.032E-04	FABP3, FABP4, FFAR4

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	1.737E-04	1.906E-03	CYP1A1, CYP1B1
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	4.187E-04	1.906E-03	ALOX15, PTGS1
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3.664E-04	1.906E-03	CYP1A1, CYP1B1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5.802E-04	1.906E-03	CYP1A1, CYP1B1
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	2.721E-04	1.906E-03	CYP1A1, CYP1B1
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	3.416E-04	1.906E-03	FABP4, PTGS1
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	5.185E-04	1.906E-03	FABP3, FABP4
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	1.358E-03	3.471E-03	ALOX15, PTGS1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	7.315E-04	2.103E-03	CYP1A1, CYP1B1

Showing 1 to 9 of 9 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Colorectal cancer	C18-C21	PTGS1;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	PTGS1;
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	FFAR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	FFAR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	FFAR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	PTGS1;
E00-E89: Endocrine, nutritional and metabolic diseases	Dietary shortage	E40-E46	PTGS1;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	PTGS1;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	PTGS1;
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	PTGS1;

Showing 1 to 10 of 18 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Daiswa polyphylla

Taxonomic Information:

Plant External Links:

Used in Medicines:

Country/Region:

Traditional Medicine System:

Geographical Distribution:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities