CMAUP Plant Collective Molecular Activities

Plant Name: Sterculia urens

Taxonomic Information:

Plant ID: NPO27306
Plant Latin Name: Sterculia urens
Taxonomy Genus: Sterculia
Taxonomy Family: Malvaceae

Plant External Links:

NCBI TaxonomyDB: 482950
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Philippines; India

Traditional Medicine System:

Geographical Distribution:

Philippines; India

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	HPGD;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:2001300; lipoxin metabolic process	3.106E-04	1.000E+00	HPGD
BP	GO:0008152; metabolic process	GO:0019372; lipoxygenase pathway	8.283E-04	1.000E+00	HPGD
BP	GO:0022414; reproductive process	GO:0030728; ovulation	9.319E-04	1.000E+00	HPGD
BP	GO:0008283; cell proliferation	GO:1904707; positive regulation of vascular smooth muscle cell proliferation	1.139E-03	1.000E+00	HPGD
BP	GO:0008152; metabolic process	GO:0006693; prostaglandin metabolic process	1.346E-03	1.000E+00	HPGD
BP	GO:0050896; response to stimulus	GO:0045471; response to ethanol	6.005E-03	1.000E+00	HPGD
BP	GO:0050896; response to stimulus	GO:0032355; response to estradiol	6.420E-03	1.000E+00	HPGD
BP	GO:0050896; response to stimulus	GO:0032496; response to lipopolysaccharide	1.434E-02	1.000E+00	HPGD
BP	GO:0009987; cellular process	GO:0045786; negative regulation of cell cycle	3.003E-02	1.000E+00	HPGD
BP	GO:0009987; cellular process	GO:0043065; positive regulation of apoptotic process	3.148E-02	1.000E+00	HPGD
BP	GO:0008152; metabolic process	GO:0055114; oxidation-reduction process	4.649E-02	1.000E+00	HPGD
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	9.629E-03	1.000E+00	HPGD
MF	GO:0005488; binding	GO:0042803; protein homodimerization activity	4.116E-02	1.000E+00	HPGD

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	9.000E-03	9.000E-03	HPGD

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases