Plant Name: Annona impressivenia
Taxonomic Information:
Plant ID: NPO27269
Plant Latin Name: Annona impressivenia
Taxonomy Genus: Annona
Taxonomy Family: Annonaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
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See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| FFAR4; FFAR1; | |
| NPSR1; | |
| ALPL; ALOX12; HSD17B2; HSD17B10; ALOX15; NOX4; APEX1; POLB; | |
| ACHE; | |
| BCL2; | |
| CDK6; PIM1; MET; AXL; PRKCA; FLT3; CDK1; KDR; IGF1R; AURKB; | |
| CA2; CA12; CA14; CA7; CA1; | |
| PPARA; | |
| NR1H4; | |
| TYR; | |
| KDM4E; | |
| F10; | |
| AHR; NFKB1; | |
| FUT7; | |
| SLCO1B1; | |
| LMNA; FABP3; FABP5; FABP4; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Enzyme_unclassified | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P05186 | CHEMBL5979 |
| Enzyme_unclassified | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Enzyme_unclassified | HSD17B2 | Estradiol 17-beta-dehydrogenase 2 | P37059 | CHEMBL2789 |
| Enzyme_unclassified | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
| Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
| Enzyme_unclassified | NOX4 | NADPH oxidase 4 | Q9NPH5 | CHEMBL1250375 |
| Enzyme_unclassified | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | P27695 | CHEMBL5619 |
Showing 1 to 10 of 44 entries
Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0009987; cellular process | GO:0043066; negative regulation of apoptotic process | 3.409E-08 | 2.855E-05 | ALOX12, AURKB, AXL, BCL2, CDK1, FFAR4, IGF1R, KDR, LMNA, NFKB1, NR1H4, PIM1, PRKCA |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 4.931E-08 | 3.472E-05 | CA1, CA12, CA14, CA2, CA7 |
| BP | GO:0065007; biological regulation | GO:0010817; regulation of hormone levels | 1.640E-07 | 8.929E-05 | ACHE, CYP1A1, CYP1B1, FFAR1, FFAR4, HSD17B2, NFKB1, NR1H4, PRKCA, SLCO1B1 |
| BP | GO:0065007; biological regulation | GO:0048878; chemical homeostasis | 8.855E-07 | 3.268E-04 | ALOX12, BCL2, CA12, CA2, CA7, FABP3, FABP4, FFAR1, MET, NOX4, NPSR1, NR1H4 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 1.308E-06 | 4.130E-04 | CA1, CA12, CA2, CA7 |
| BP | GO:0008152; metabolic process | GO:0097267; omega-hydroxylase P450 pathway | 1.309E-06 | 4.130E-04 | CYP1A1, CYP1A2, CYP1B1 |
| BP | GO:0050896; response to stimulus | GO:0009725; response to hormone | 1.758E-06 | 5.172E-04 | ALPL, APEX1, BCL2, CA2, CYP1A2, FABP3, FFAR4, FLT3, NFKB1, PPARA |
| BP | GO:0050896; response to stimulus | GO:0009611; response to wounding | 3.069E-06 | 8.535E-04 | ACHE, ALOX15, BCL2, CDK1, CYP1A1, PPARA |
| BP | GO:0008152; metabolic process | GO:0055114; oxidation-reduction process | 3.858E-06 | 9.883E-04 | ALOX12, ALOX15, APEX1, CYP1A1, CYP1A2, CYP1B1, HSD17B10, HSD17B2, KDM4E, NOX4, TYR |
| BP | GO:0009987; cellular process | GO:0006286; base-excision repair, base-free sugar-phosphate removal | 5.071E-06 | 1.175E-03 | APEX1, POLB |
Showing 1 to 10 of 35 entries
Enriched KEGG Pathways of Target Proteins (Activity≤1μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09102 Energy metabolism | hsa00910 | Nitrogen metabolism | 2.473E-10 | 3.758E-08 | CA12, CA1, CA2, CA7, CA14 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00140 | Steroid hormone biosynthesis | 7.926E-06 | 2.668E-04 | CYP1A2, HSD17B2, CYP1A1, CYP1B1 |
| 09100 Metabolism | 09105 Amino acid metabolism | hsa00380 | Tryptophan metabolism | 9.273E-05 | 1.281E-03 | CYP1A2, CYP1A1, CYP1B1 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 5.549E-04 | 4.686E-03 | CYP1A2, CYP1A1, CYP1B1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04151 | PI3K-Akt signaling pathway | 8.776E-06 | 2.668E-04 | CDK6, KDR, BCL2, PRKCA, MET, NFKB1, IGF1R |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04066 | HIF-1 signaling pathway | 7.687E-05 | 1.199E-03 | BCL2, PRKCA, NFKB1, IGF1R |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04014 | Ras signaling pathway | 1.365E-04 | 1.729E-03 | KDR, PRKCA, MET, NFKB1, IGF1R |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04015 | Rap1 signaling pathway | 1.175E-03 | 7.142E-03 | KDR, PRKCA, MET, IGF1R |
| 09140 Cellular Processes | 09144 Cellular community - eukaryotes | hsa04510 | Focal adhesion | 7.887E-05 | 1.199E-03 | KDR, BCL2, PRKCA, MET, IGF1R |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04913 | Ovarian steroidogenesis | 4.358E-06 | 2.208E-04 | HSD17B2, CYP1A1, CYP1B1, IGF1R |
Showing 1 to 10 of 26 entries
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| A00-B99: Certain infectious and parasitic diseases | Helminth infection | A00-B99 | ACHE; |
| A00-B99: Certain infectious and parasitic diseases | Human immunodeficiency virus infection | B20-B26 | FLT3; |
| A00-B99: Certain infectious and parasitic diseases | Anthelmintic | B89 | ALPL; |
| A00-B99: Certain infectious and parasitic diseases | Pediculus humanus capitis | B85.0 | ACHE; |
| C00-D49: Neoplasms | Metastatic breast cancer | C50 | KDR; |
| C00-D49: Neoplasms | Metastatic castration-resistant prostate cancer | C61 | KDR; |
| C00-D49: Neoplasms | Squamous cell cancer of head and neck | NA | KDR; |
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | AURKB; |
| C00-D49: Neoplasms | Hepatocellular carcinoma | C22.0 | MET; IGF1R; KDR; |
| C00-D49: Neoplasms | Advanced renal cell carcinoma | C64 | KDR; |
Showing 1 to 10 of 125 entries
>> Profiles of ingredients and activity landscape
>> Collective molecular activities profile at 10μM cutoff
>> Targets derived from weak experimental activities
