CMAUP Plant Collective Molecular Activities

Plant Name: Dysosma pleiantha

Taxonomic Information:

Plant ID: NPO27244
Plant Latin Name: Dysosma pleiantha
Taxonomy Genus: Dysosma
Taxonomy Family: Berberidaceae

Plant External Links:

NCBI TaxonomyDB: 63349
Plant-of-the-World-Online: 107253-1

Used in Medicines:

Unknown.

Geographical Distribution:

Taiwan; China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Unclassified	GLI1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Unclassified	GLI1	Zinc finger protein GLI1	P08151	CHEMBL5461

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0032502; developmental process	GO:0060032; notochord regression	2.071E-04	5.203E-01	GLI1
BP	GO:0008152; metabolic process	GO:0009822; alkaloid catabolic process	3.106E-04	5.203E-01	CYP3A4
BP	GO:0032502; developmental process	GO:0007418; ventral midline development	3.106E-04	5.203E-01	GLI1
MF	GO:0003824; catalytic activity	GO:0070576; vitamin D 24-hydroxylase activity	3.106E-04	5.203E-01	CYP3A4
BP	GO:0023052; signaling	GO:0021938; smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation	4.141E-04	5.305E-01	GLI1
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	4.141E-04	5.305E-01	CYP3A4
BP	GO:0032502; developmental process	GO:0021696; cerebellar cortex morphogenesis	5.177E-04	5.368E-01	GLI1
CC	GO:0044464; cell part	GO:0005737; cytoplasm	4.631E-02	1.000E+00	CYP3A4, GLI1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	2.898E-03	1.053E-02	CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	4.595E-03	1.053E-02	CYP3A4
09160 Human Diseases	09161 Cancers	hsa05217	Basal cell carcinoma	5.493E-03	1.053E-02	GLI1
09130 Environmental Information Processing	09132 Signal transduction	hsa04340	Hedgehog signaling pathway	4.994E-03	1.053E-02	GLI1
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	6.490E-03	1.053E-02	CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	5.792E-03	1.053E-02	CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	6.888E-03	1.053E-02	CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7.287E-03	1.053E-02	CYP3A4
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	7.088E-03	1.053E-02	CYP3A4
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	8.183E-03	1.064E-02	CYP3A4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases