CMAUP Plant Collective Molecular Activities

Plant Name: Prunus tomentosa

Taxonomic Information:

Plant ID: NPO27241
Plant Latin Name: Prunus tomentosa
Taxonomy Genus: Prunus
Taxonomy Family: Rosaceae

Plant External Links:

NCBI TaxonomyDB: 105667
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

South Korea

Traditional Medicine System:

Geographical Distribution:

South Korea

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Nuclear hormone receptor subfamily 1 group H	NR1H3;
ATP-binding cassette	ABCB1;
Unclassified	NPC1L1; LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
ATP-binding cassette	ABCB1	P-glycoprotein 1	P08183	CHEMBL4302
Nuclear hormone receptor subfamily 1 group H	NR1H3	LXR-alpha	Q13133	CHEMBL2808
Unclassified	NPC1L1	Niemann-Pick C1-like protein 1	Q9UHC9	CHEMBL2027
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0050896; response to stimulus	GO:0042493; response to drug	2.150E-04	8.502E-01	ABCB1, NPC1L1, NR1H3
BP	GO:0051179; localization	GO:0042908; xenobiotic transport	2.069E-03	8.502E-01	ABCB1
MF	GO:0005215; transporter activity	GO:0008559; xenobiotic transmembrane transporting ATPase activity	1.449E-03	8.502E-01	ABCB1
CC	GO:0032991; macromolecular complex	GO:0090575; RNA polymerase II transcription factor complex	2.686E-02	1.000E+00	NR1H3

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09154 Digestive system	hsa04975	Fat digestion and absorption	8.175E-03	3.065E-02	NPC1L1
09130 Environmental Information Processing	09131 Membrane transport	hsa02010	ABC transporters	8.772E-03	3.065E-02	ABCB1
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	1.373E-02	3.065E-02	NR1H3
09160 Human Diseases	09165 Cardiovascular diseases	hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	1.472E-02	3.065E-02	LMNA
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	1.413E-02	3.065E-02	ABCB1
09160 Human Diseases	09165 Cardiovascular diseases	hsa05410	Hypertrophic cardiomyopathy (HCM)	1.650E-02	3.065E-02	LMNA
09160 Human Diseases	09165 Cardiovascular diseases	hsa05414	Dilated cardiomyopathy	1.788E-02	3.065E-02	LMNA
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	2.162E-02	3.244E-02	NR1H3
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	2.771E-02	3.258E-02	LMNA
09160 Human Diseases	09167 Infectious diseases	hsa05160	Hepatitis C	2.634E-02	3.258E-02	NR1H3

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases