Plant Name: Atropa belladona
Taxonomic Information:
Plant ID: NPO27168
Plant Latin Name: Atropa belladona
Taxonomy Genus: Atropa
Taxonomy Family: Solanaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| ATP1A1; | |
| RECQL; | |
| RORC; | |
| STAT3; TP53; | |
| SLCO4C1; SLCO1B1; | |
| RAB9A; MAPT; PAX8; LMNA; NPC1; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Hydrolase | ATP1A1 | Sodium/potassium-transporting ATPase alpha-1 chain | P05023 | CHEMBL1807 |
| Nuclear hormone receptor subfamily 1 group F | RORC | Nuclear receptor ROR-gamma | P51449 | CHEMBL1741186 |
| SLC superfamily of solute carriers | SLCO4C1 | Solute carrier organic anion transporter family member 4C1 | Q6ZQN7 | CHEMBL2073690 |
| SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
| Transcription Factor | STAT3 | Signal transducer and activator of transcription 3 | P40763 | CHEMBL4026 |
| Transcription Factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
| Unclassified | RAB9A | Ras-related protein Rab-9A | P51151 | CHEMBL1293294 |
| Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
| Unclassified | PAX8 | Paired box protein Pax-8 | Q06710 | CHEMBL2362980 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Unclassified | NPC1 | Niemann-Pick C1 protein | O15118 | CHEMBL1293277 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0009987; cellular process | GO:0000733; DNA strand renaturation | 1.271E-05 | 9.223E-02 | RECQL, TP53 |
| BP | GO:0050896; response to stimulus | GO:0032870; cellular response to hormone stimulus | 4.321E-05 | 9.368E-02 | ATP1A1, NPC1, PAX8, STAT3 |
| BP | GO:0050896; response to stimulus | GO:0033993; response to lipid | 4.579E-05 | 9.368E-02 | ATP1A1, NPC1, RORC, STAT3, TP53 |
| BP | GO:0009987; cellular process | GO:0071407; cellular response to organic cyclic compound | 4.728E-05 | 9.368E-02 | ATP1A1, NPC1, RORC, STAT3 |
| BP | GO:0008152; metabolic process | GO:1902895; positive regulation of pri-miRNA transcription from RNA polymerase II promoter | 8.117E-05 | 1.473E-01 | STAT3, TP53 |
| MF | GO:0005215; transporter activity | GO:0015347; sodium-independent organic anion transmembrane transporter activity | 9.691E-05 | 1.623E-01 | SLCO1B1, SLCO4C1 |
| MF | GO:0005488; binding | GO:0051721; protein phosphatase 2A binding | 1.325E-04 | 1.652E-01 | MAPT, TP53 |
| CC | GO:0016020; membrane | GO:0016323; basolateral plasma membrane | 1.813E-04 | 1.829E-01 | ATP1A1, SLCO1B1, SLCO4C1 |
| MF | GO:0140110; transcription regulator activity | GO:0004879; nuclear receptor activity | 4.094E-04 | 2.409E-01 | RORC, STAT3 |
| MF | GO:0005488; binding | GO:0000977; RNA polymerase II regulatory region sequence-specific DNA binding | 4.474E-04 | 2.436E-01 | PAX8, RORC, STAT3, TP53 |
| CC | GO:0043226; organelle | GO:0016604; nuclear body | 7.227E-04 | 3.026E-01 | LMNA, MAPT, RORC, TP53 |
| CC | GO:0043226; organelle | GO:0042470; melanosome | 1.727E-03 | 3.497E-01 | ATP1A1, RAB9A |
| CC | GO:0032991; macromolecular complex | GO:0090575; RNA polymerase II transcription factor complex | 2.881E-03 | 4.022E-01 | STAT3, TP53 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09160 Human Diseases | 09167 Infectious diseases | hsa05162 | Measles | 6.469E-05 | 4.528E-03 | STAT3, RAB9A, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05216 | Thyroid cancer | 1.328E-04 | 4.648E-03 | PAX8, TP53 |
| 09160 Human Diseases | 09162 Immune diseases | hsa05321 | Inflammatory bowel disease (IBD) | 6.722E-04 | 9.350E-03 | STAT3, RORC |
| 09160 Human Diseases | 09161 Cancers | hsa05212 | Pancreatic cancer | 6.929E-04 | 9.350E-03 | STAT3, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05200 | Pathways in cancer | 1.495E-03 | 1.495E-02 | PAX8, STAT3, TP53 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04918 | Thyroid hormone synthesis | 8.014E-04 | 9.350E-03 | PAX8, ATP1A1 |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 8.014E-04 | 9.350E-03 | SLCO1B1, ATP1A1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04919 | Thyroid hormone signaling pathway | 2.192E-03 | 1.918E-02 | ATP1A1, TP53 |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 3.067E-03 | 2.119E-02 | LMNA, TP53 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05160 | Hepatitis C | 2.773E-03 | 2.119E-02 | STAT3, TP53 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | TP53; |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Anesthesia | R20.0 | ATP1A1; |
| C00-D49: Neoplasms | Late-stage solid tumors | C00-C75, C7A, C7B, D10-D36, D3A | TP53; |
| J00-J99: Diseases of the respiratory system | Chronic obstructive pulmonary disease | J40-J44, J47 | ATP1A1; |
| G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | MAPT; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Cognitive disorders | F01-F07, F04, F05, R41.3 | MAPT; |
| I00-I99: Diseases of the circulatory system | Congestive heart failure | I50 | ATP1A1; |
| NA: NA | Congestive cardiac insufficiency | NA | ATP1A1; |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | TP53; |
| L00-L99: Diseases of the skin and subcutaneous tissue | Psoriasis | L40 | STAT3; |
| C00-D49: Neoplasms | Multiple myeloma | C90 | STAT3; |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | TP53; |
| H60-H95: Diseases of the ear and mastoid process | Hearing disorder | H90.5 | TP53; |
| I00-I99: Diseases of the circulatory system | Heart failure | I50 | ATP1A1; |
| A00-B99: Certain infectious and parasitic diseases | Malaria | B54 | ATP1A1; |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Hyperhidrosis | R61 | ATP1A1; |
| A00-B99: Certain infectious and parasitic diseases | Fungal infections | B35-B49 | RAB9A; |
| C00-D49: Neoplasms | Oral cavity cancer | C00-C08 | TP53; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Atrial fibrillation | E78, I48 | ATP1A1; |
| C00-D49: Neoplasms | Hepatocellular carcinoma | C22.0 | STAT3; |
| NA: NA | Arrhythmias | NA | ATP1A1; |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Toxicity | T36-T50, T51-T65 | TP53; |
| I00-I99: Diseases of the circulatory system | Renal artery disease | I70.1 | TP53; |
| G00-G99: Diseases of the nervous system G00-G99 | Neurodegenerative disease | G30-G32 | MAPT; |
| C00-D49: Neoplasms | Cancer | C00-C96 | STAT3; ATP1A1; TP53; |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | TP53; |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | STAT3; TP53; |
| G00-G99: Diseases of the nervous system G00-G99 | Central nervous system disease | G00-G99 | MAPT; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
