CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Hydrolase	ATP1A1;
Enzyme_unclassified	RECQL;
Nuclear hormone receptor subfamily 1 group F	RORC;
Transcription Factor	STAT3; TP53;
SLC superfamily of solute carriers	SLCO4C1; SLCO1B1;
Unclassified	RAB9A; MAPT; PAX8; LMNA; NPC1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Hydrolase	ATP1A1	Sodium/potassium-transporting ATPase alpha-1 chain	P05023	CHEMBL1807
Nuclear hormone receptor subfamily 1 group F	RORC	Nuclear receptor ROR-gamma	P51449	CHEMBL1741186
SLC superfamily of solute carriers	SLCO4C1	Solute carrier organic anion transporter family member 4C1	Q6ZQN7	CHEMBL2073690
SLC superfamily of solute carriers	SLCO1B1	Solute carrier organic anion transporter family member 1B1	Q9Y6L6	CHEMBL1697668
Transcription Factor	STAT3	Signal transducer and activator of transcription 3	P40763	CHEMBL4026
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	PAX8	Paired box protein Pax-8	Q06710	CHEMBL2362980

Showing 1 to 10 of 12 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0000733; DNA strand renaturation	1.271E-05	9.223E-02	RECQL, TP53
BP	GO:0050896; response to stimulus	GO:0032870; cellular response to hormone stimulus	4.321E-05	9.368E-02	ATP1A1, NPC1, PAX8, STAT3
BP	GO:0050896; response to stimulus	GO:0033993; response to lipid	4.579E-05	9.368E-02	ATP1A1, NPC1, RORC, STAT3, TP53
BP	GO:0009987; cellular process	GO:0071407; cellular response to organic cyclic compound	4.728E-05	9.368E-02	ATP1A1, NPC1, RORC, STAT3
BP	GO:0008152; metabolic process	GO:1902895; positive regulation of pri-miRNA transcription from RNA polymerase II promoter	8.117E-05	1.473E-01	STAT3, TP53
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	1.813E-04	1.829E-01	ATP1A1, SLCO1B1, SLCO4C1
CC	GO:0043226; organelle	GO:0016604; nuclear body	7.227E-04	3.026E-01	LMNA, MAPT, RORC, TP53
CC	GO:0043226; organelle	GO:0042470; melanosome	1.727E-03	3.497E-01	ATP1A1, RAB9A
CC	GO:0032991; macromolecular complex	GO:0090575; RNA polymerase II transcription factor complex	2.881E-03	4.022E-01	STAT3, TP53
MF	GO:0005215; transporter activity	GO:0015347; sodium-independent organic anion transmembrane transporter activity	9.691E-05	1.623E-01	SLCO1B1, SLCO4C1

Showing 1 to 10 of 13 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	3.067E-03	2.119E-02	LMNA, TP53
09150 Organismal Systems	09152 Endocrine system	hsa04918	Thyroid hormone synthesis	8.014E-04	9.350E-03	PAX8, ATP1A1
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	8.014E-04	9.350E-03	SLCO1B1, ATP1A1
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	2.192E-03	1.918E-02	ATP1A1, TP53
09160 Human Diseases	09167 Infectious diseases	hsa05162	Measles	6.469E-05	4.528E-03	STAT3, RAB9A, TP53
09160 Human Diseases	09161 Cancers	hsa05216	Thyroid cancer	1.328E-04	4.648E-03	PAX8, TP53
09160 Human Diseases	09162 Immune diseases	hsa05321	Inflammatory bowel disease (IBD)	6.722E-04	9.350E-03	STAT3, RORC
09160 Human Diseases	09161 Cancers	hsa05212	Pancreatic cancer	6.929E-04	9.350E-03	STAT3, TP53
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	1.495E-03	1.495E-02	PAX8, STAT3, TP53
09160 Human Diseases	09167 Infectious diseases	hsa05160	Hepatitis C	2.773E-03	2.119E-02	STAT3, TP53

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ATP1A1;
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	RAB9A;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	TP53;
C00-D49: Neoplasms	Multiple myeloma	C90	STAT3;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53;
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	STAT3;
C00-D49: Neoplasms	Cancer	C00-C96	STAT3; ATP1A1; TP53;

Showing 1 to 10 of 28 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Atropa belladona

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities