CMAUP Plant Collective Molecular Activities

Plant Name: Daiswa dunniana

Taxonomic Information:

Plant ID: NPO27144
Plant Latin Name: Daiswa dunniana
Taxonomy Genus: Daiswa
Taxonomy Family: Melanthiaceae

Plant External Links:

NCBI TaxonomyDB: 374961
Plant-of-the-World-Online: n.a.

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Hydrolase	ACHE;
Lyase	CA12; CA9;
Transcription Factor	NFKB1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2D6; CYP2A6; CYP3A4; CYP2C19; CYP2C9;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 2	CYP2A6	Cytochrome P450 2A6	P11509	CHEMBL5282
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	5.430E-13	1.182E-08	CYP2C19, CYP2C9, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	3.111E-12	3.387E-08	CYP2A6, CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	1.789E-11	9.739E-08	CYP2A6, CYP2C19, CYP2C9, CYP3A4
MF	GO:0005488; binding	GO:0020037; heme binding	2.899E-09	1.052E-05	CYP2A6, CYP2C19, CYP2C9, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0019825; oxygen binding	5.341E-09	1.454E-05	CYP2C19, CYP2C9, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0005506; iron ion binding	8.926E-09	1.944E-05	CYP2A6, CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	2.193E-08	3.979E-05	CYP2C9, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0008392; arachidonic acid epoxygenase activity	6.769E-08	1.053E-04	CYP2A6, CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	7.853E-08	1.069E-04	CYP2A6, CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	1.322E-07	1.589E-04	CYP2A6, CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	2.351E-07	2.226E-04	CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0009822; alkaloid catabolic process	7.235E-07	6.059E-04	CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	1.447E-06	1.086E-03	CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0044281; small molecule metabolic process	4.119E-06	2.718E-03	CA12, CA9, CYP2A6, CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0009804; coumarin metabolic process	5.059E-06	3.060E-03	CYP2A6, CYP2D6
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	1.083E-05	5.896E-03	CYP2C19, CYP2C9
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	5.026E-05	2.432E-02	CYP2A6, CYP2C19, CYP2C9, CYP2D6, CYP3A4

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.048E-10	7.444E-09	CYP2C9, CYP2A6, CYP2D6, CYP3A4, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3.373E-08	1.197E-06	CYP2C9, CYP2A6, CYP2D6, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	5.409E-08	1.280E-06	CYP2C9, CYP2A6, CYP3A4, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	3.267E-07	5.798E-06	CYP2C9, CYP3A4, CYP2C19
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3.868E-06	5.493E-05	CYP2C9, CYP2A6, CYP3A4
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	1.994E-05	2.359E-04	CYP2C9, CYP2D6, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	4.187E-04	3.303E-03	CYP2C9, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	2.302E-04	2.043E-03	CYP2A6, CYP3A4
Unclassified	Unclassified	hsa01100	Metabolic pathways	2.276E-03	1.612E-02	CYP2C9, CYP2A6, CYP2C19, CYP3A4
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	3.048E-05	3.091E-04	CA12, CA9

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
C00-D49: Neoplasms	Breast cancer	C50	CA9;
C00-D49: Neoplasms	Cancer	C00-C96	CA9;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases