Plant Name: Senecio macrophyllus
Taxonomic Information:
Plant ID: NPO27038
Plant Latin Name: Senecio macrophyllus
Taxonomy Genus: Senecio
Taxonomy Family: Asteraceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| NR1H4; | |
| HSD17B10; HPGD; ALDH1A1; | |
| CASP7; CASP1; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cysteine protease | CASP7 | Caspase-7 | P55210 | CHEMBL3468 |
| Cysteine protease | CASP1 | Caspase-1 | P29466 | CHEMBL4801 |
| Enzyme_unclassified | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
| Enzyme_unclassified | HPGD | 15-hydroxyprostaglandin dehydrogenase [NAD+] | P15428 | CHEMBL1293255 |
| Enzyme_unclassified | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P00352 | CHEMBL3577 |
| Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0003824; catalytic activity | GO:0097200; cysteine-type endopeptidase activity involved in execution phase of apoptosis | 6.262E-06 | 1.049E-01 | CASP1, CASP7 |
| BP | GO:0009987; cellular process | GO:0097194; execution phase of apoptosis | 5.625E-05 | 2.416E-01 | CASP1, CASP7 |
| BP | GO:0050896; response to stimulus | GO:0032496; response to lipopolysaccharide | 5.651E-05 | 2.416E-01 | CASP1, HPGD, NR1H4 |
| BP | GO:0009987; cellular process | GO:0010803; regulation of tumor necrosis factor-mediated signaling pathway | 1.365E-04 | 2.416E-01 | CASP1, NR1H4 |
| BP | GO:0008152; metabolic process | GO:0006629; lipid metabolic process | 2.075E-04 | 2.416E-01 | ALDH1A1, HPGD, HSD17B10, NR1H4 |
| BP | GO:0065007; biological regulation | GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process | 2.641E-04 | 2.416E-01 | CASP1, CASP7 |
| MF | GO:0005488; binding | GO:0051287; NAD binding | 1.365E-04 | 2.416E-01 | ALDH1A1, HPGD |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09160 Human Diseases | 09167 Infectious diseases | hsa05134 | Legionellosis | 1.106E-04 | 1.649E-03 | CASP7, CASP1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05133 | Pertussis | 2.061E-04 | 1.649E-03 | CASP7, CASP1 |
| 09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05010 | Alzheimer's disease | 1.029E-03 | 5.488E-03 | CASP7, HSD17B10 |
| 09100 Metabolism | 09105 Amino acid metabolism | hsa00280 | Valine, leucine and isoleucine degradation | 1.432E-02 | 3.754E-02 | HSD17B10 |
| 09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05014 | Amyotrophic lateral sclerosis (ALS) | 1.520E-02 | 3.754E-02 | CASP1 |
| 09150 Organismal Systems | 09151 Immune system | hsa04621 | NOD-like receptor signaling pathway | 1.698E-02 | 3.754E-02 | CASP1 |
| 09100 Metabolism | 09108 Metabolism of cofactors and vitamins | hsa00830 | Retinol metabolism | 1.934E-02 | 3.754E-02 | ALDH1A1 |
| 09150 Organismal Systems | 09151 Immune system | hsa04623 | Cytosolic DNA-sensing pathway | 1.905E-02 | 3.754E-02 | CASP1 |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 2.111E-02 | 3.754E-02 | NR1H4 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05132 | Salmonella infection | 2.553E-02 | 4.084E-02 | CASP1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
